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Search results 101 to 109 out of 109 for Pstpip1

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0.016s

Type

Details

Score

Publication

18480402 | -

First Author:	Cooper KM
Year:	2008
Journal:	Mol Biol Cell
Title:	The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
Volume:	19
Issue:	8
Pages:	3180-91

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Publication

22161697 | -

First Author:	Demidowich AP
Year:	2012
Journal:	Arthritis Rheum
Title:	Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne).
Volume:	64
Issue:	6
Pages:	2022-7

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Publication

14595024 | -

First Author:	Shoham NG
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.
Volume:	100
Issue:	23
Pages:	13501-6

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Protein Domain

IPR030777 | PSTPIP1_SH3

Type:

Domain

Description:

This entry represents the SH3 domain of proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1).Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) belongs to the PCH family. It interacts with Wiskott-Aldrich syndrome protein (WASP) and PTPN12, which are important regulators of the cytoskeleton and cell migration, suggesting that PSTPIP1 functions in these pathways []. PSTPIP1 has been identified as a component of the leukocyte uropod that regulates endocytosis and cell migration []. It also controls extracellular matrix degradation and filopodia formation in macrophages []. It interacts with pyrin, a protein that associates with the cytoskeleton in myeloid/monocytic cells and modulates IL-1beta processing, NF-kappaB activation, and apoptosis []. Mutations in the PSTPIP1 gene have been linked to PAPA syndrome, an inflammatory disease [].Pombe Cdc15 homology (PCH) family proteins were initially identified as adaptor proteins involved in the regulation of cytokinesis and actin dynamics []. They share a similar domain architecture, consisting of an N-terminal FCH domain followed by a coiled coil (CC) region and by one or two C-terminal SH3 domains. However, in some family members the SH3 domain is absent (FCHO1, FCHO2 and PSTPIP2) or there are tissue-specific alternatively spliced isoforms with and without an SH3 domain (CIP4b, CIP4c, CIP4V, Fbp17b). PCH family proteins interact with receptors, adaptors, enzymes and structural proteins to regulate their localisation and activity. Through these interactions, PCH proteins regulate cell morphology and motility, organelle integrity, protein trafficking and the organisation of the actin cytoskeleton [].

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Publication

10816256 | -

First Author:	Lippincott J
Year:	2000
Journal:	Microsc Res Tech
Title:	Involvement of PCH family proteins in cytokinesis and actin distribution.
Volume:	49
Issue:	2
Pages:	168-72

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Publication

17296299 | -

First Author:	Chitu V
Year:	2007
Journal:	Trends Cell Biol
Title:	Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions.
Volume:	17
Issue:	3
Pages:	145-56

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Publication

16122996 | J:104476

First Author:	Ferguson PJ
Year:	2006
Journal:	Bone
Title:	A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis.
Volume:	38
Issue:	1
Pages:	41-7

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Protein

P97814

Organism:	Mus musculus/domesticus
Length:	415
Fragment?:	false

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Protein

A0A0R4J0P5

Organism:	Mus musculus/domesticus
Length:	415
Fragment?:	false

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