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Search results 101 to 200 out of 259 for Ptk6

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Type Details Score
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
23856248 | J:201832
First Author: Zheng Y
Year: 2013
Journal: Cancer Res
Title: PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.
Volume: 73
Issue: 17
Pages: 5426-37
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UniProt Feature
UniProt Feature
Begin: 64
Description: Phosphotyrosine; by PTK6
Type: modified residue
End: 64
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UniProt Feature
UniProt Feature
Begin: 118
Description: Phosphotyrosine; by PTK6
Type: modified residue
End: 118
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UniProt Feature
UniProt Feature
Begin: 31
Description: Phosphotyrosine; by PTK6
Type: modified residue
End: 31
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UniProt Feature
UniProt Feature
Begin: 443
Description: Phosphotyrosine; by PTK6
Type: modified residue
End: 443
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UniProt Feature
UniProt Feature
Begin: 440
Description: Phosphotyrosine; by PTK6
Type: modified residue
End: 440
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UniProt Feature
UniProt Feature
Begin: 435
Description: Phosphotyrosine; by PTK6
Type: modified residue
End: 435
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UniProt Feature
UniProt Feature
Begin: 250
Description: Phosphotyrosine; by PTK6
Type: modified residue
End: 250
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Pathway
R-MMU-8849472 | PTK6 Down-Regulation
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UniProt Feature
UniProt Feature
Begin: 142
Description: Phosphotyrosine; by FYN and PTK6
Type: modified residue
End: 142
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UniProt Feature
UniProt Feature
Begin: 1105
Description: Phosphotyrosine; by ABL2 and PTK6
Type: modified residue
End: 1105
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UniProt Feature
UniProt Feature
Begin: 705
Description: Phosphotyrosine; by FER and PTK6
Type: modified residue
End: 705
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Publication
20193745 | -
First Author: Brauer PM
Year: 2010
Journal: Biochim Biophys Acta
Title: Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK.
Volume: 1806
Issue: 1
Pages: 66-73
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Allele
Ptk6<+> | MGI:2432671
   
Name: PTK6 protein tyrosine kinase 6; wild type
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Pathway
R-MMU-8848021 | Signaling by PTK6
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Pathway
R-MMU-8849470 | PTK6 Regulates Cell Cycle
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Pathway
R-MMU-8857538 | PTK6 promotes HIF1A stabilization
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Pathway
R-MMU-8847993 | ERBB2 Activates PTK6 Signaling
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Pathway
R-MMU-8849474 | PTK6 Activates STAT3
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Allele
Ptk6<em2Cya> | MGI:7585999
Name: PTK6 protein tyrosine kinase 6; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Ptk6<tm1Aty> | MGI:3662667
Name: PTK6 protein tyrosine kinase 6; targeted mutation 1, Angela L Tyner
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ptk6<tm1e(EUCOMM)Wtsi> | MGI:4431756
Name: PTK6 protein tyrosine kinase 6; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ptk6<tm1a(EUCOMM)Wtsi> | MGI:4433821
Name: PTK6 protein tyrosine kinase 6; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Ptk6<tm1e(EUCOMM)Hmgu> | MGI:4435099
Name: PTK6 protein tyrosine kinase 6; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ptk6<tm1a(EUCOMM)Hmgu> | MGI:4435619
Name: PTK6 protein tyrosine kinase 6; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Ptk6<tm1b(EUCOMM)Wtsi> | MGI:5708289
Name: PTK6 protein tyrosine kinase 6; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:7588957 | C57BL/6J-Ptk6<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Pathway
R-MMU-8849468 | PTK6 Regulates Proteins Involved in RNA Processing
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Pathway
R-MMU-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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Pathway
R-MMU-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
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Strain
MGI:7506571 | B6.129-Ptk6<tm1Aty>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6347039 | C57BL/6N-Ptk6<tm1a(EUCOMM)Wtsi>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6261507 | C57BL/6N-Ptk6<tm1b(EUCOMM)Wtsi>/Ucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6347040 | C57BL/6N-Ptk6<tm1b(EUCOMM)Wtsi>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Ptk6/Ptk6
Background: either: B6.Cg-Ptk6 or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk6/Ptk6
Background: C57BL/6N-Ptk6/Ucd
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:1913975 | Lrrk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2147039 | Stap2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101865 | Srms
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1934765 | Gpnmb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99P91
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Protein
Q5S006
Organism: Mus musculus/domesticus
Length: 2527  
Fragment?: false
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Protein
Q8R0L1
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q62270
Organism: Mus musculus/domesticus
Length: 496  
Fragment?: false
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Protein Coding Gene
MGI:2159649 | Khdrbs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1313312 | Khdrbs3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918764 | Sfpq
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:893579 | Khdrbs1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60749
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: false
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Protein
Q9WU01
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
Q9R226
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
Q8VIJ6
Organism: Mus musculus/domesticus
Length: 699  
Fragment?: false
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Protein Coding Gene
MGI:893587 | Dok1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P97465
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
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Publication
15056653 | -
First Author: Hong E
Year: 2004
Journal: J Biol Chem
Title: Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain.
Volume: 279
Issue: 28
Pages: 29700-8
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Publication
18719096 | -
First Author: Xiang B
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Brk is coamplified with ErbB2 to promote proliferation in breast cancer.
Volume: 105
Issue: 34
Pages: 12463-8
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Protein Domain
IPR035846 | PTK6_SH2
Type: Domain
Description: Human protein-tyrosine kinase-6 (PTK6, also known as breast tumor kinase (Brk)) is a member of the non-receptor protein-tyrosine kinase family and is expressed in two-thirds of all breast tumours []. PTK6 contains an SH3 domain, an SH2 domain, and catalytic domains. For the case of the non-receptor protein-tyrosine kinases, the SH2 domain is typically involved in negative regulation of kinase activity by binding to a phosphorylated tyrosine residue near to the C terminus. The C-terminal sequence of PTK6 (PTSpYENPT where pY is phosphotyrosine) is thought to be a self-ligand for the SH2 domain []. This entry represents the SH2 domain of PTK6. The structure of this domain resembles other SH2 domains except for a centrally located four-stranded antiparallel β-sheet (strands betaA, betaB, betaC, and betaD). There are also differences in the loop length which might be responsible for PTK6 ligand specificity []. There are two possible means of regulation of PTK6: autoinhibitory with the phosphorylation of Tyr playing a role in its negative regulation and autophosphorylation at this site, though it has been shown that PTK6 might phosphorylate signal transduction-associated proteins Sam68 and signal transducing adaptor family member 2 (STAP/BKS) in vivo [].
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Protein
Q64434
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein Coding Gene
MGI:106918 | Hif1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2153044 | Elmo1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916960 | Arap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108091 | Bcar1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q4LDD4
Organism: Mus musculus/domesticus
Length: 1452  
Fragment?: false
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Protein
Q61221
Organism: Mus musculus/domesticus
Length: 836  
Fragment?: false
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Protein
Q8BPU7
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
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Protein
Q61140
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
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Publication
27650679 | J:242178
 
First Author: Kikuchi I
Year: 2016
Journal: Nat Commun
Title: Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.
Volume: 7
Pages: 12887
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Protein Coding Gene
MGI:95411 | Erbb3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1201791 | Socs3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97860 | Rasa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2153045 | Elmo2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108295 | Pxn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61526
Organism: Mus musculus/domesticus
Length: 1339  
Fragment?: false
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Protein
Q8VI36
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q8BHL5
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
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Protein
O35718
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Protein
E9PYG6
Organism: Mus musculus/domesticus
Length: 1038  
Fragment?: false
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Protein Coding Gene
MGI:104771 | Erbb4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95410 | Erbb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103038 | Stat3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1097165 | Nrg3
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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