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Search results 101 to 115 out of 115 for Ptpa

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0.017s

Type

Details

Score

Protein

Q8C0E1

Organism:	Mus musculus/domesticus
Length:	323
Fragment?:	false

•

Protein

A2AWF0

Organism:	Mus musculus/domesticus
Length:	104
Fragment?:	false

•

Protein

A2AWE9

Organism:	Mus musculus/domesticus
Length:	281
Fragment?:	false

•

Protein

Q543N6

Organism:	Mus musculus/domesticus
Length:	323
Fragment?:	false

•

Publication

16916641 | -

First Author:	Chao Y
Year:	2006
Journal:	Mol Cell
Title:	Structure and mechanism of the phosphotyrosyl phosphatase activator.
Volume:	23
Issue:	4
Pages:	535-46

•

Publication

16885030 | -

First Author:	Leulliot N
Year:	2006
Journal:	Mol Cell
Title:	Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Volume:	23
Issue:	3
Pages:	413-24

•

Publication

16782712 | -

First Author:	Magnusdottir A
Year:	2006
Journal:	J Biol Chem
Title:	The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.
Volume:	281
Issue:	32
Pages:	22434-8

•

Publication

16380387 | -

First Author:	Jordens J
Year:	2006
Journal:	J Biol Chem
Title:	The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase.
Volume:	281
Issue:	10
Pages:	6349-57

•

Publication

11171037 | -

First Author:	Janssens V
Year:	2001
Journal:	Biochem J
Title:	Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.
Volume:	353
Issue:	Pt 3
Pages:	417-39

•

Protein Coding Gene

MGI:97808 | Ptpra

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

P18052

Organism:	Mus musculus/domesticus
Length:	829
Fragment?:	false

•

Protein

P18052-2

Organism:	Mus musculus/domesticus
Length:	794
Fragment?:	false

•

DO Term

DOID:0070486 | Parkinson's disease 25

•

Protein Domain

IPR043170 | PTPA_C_lid

Type:

Homologous_superfamily

Description:

Phosphotyrosyl phosphatase activator (PTPA, also known as protein phosphatase 2A activator) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. It also reactivates the serine/threonine phosphatase activity of an inactive form of PP2A. The specific biological role of PTPA is unknown. PTPA has been suggested to play a role in the insertion of metals to the PP2A catalytic subunit (PP2Ac) active site, to act as a chaperone, and more recently, to have peptidyl prolyl cis/trans isomerase activity that specifically targets human PP2Ac [, , , , , ]. Together, PTPA and PP2A constitute an ATPase and it has been suggested that PTPA alters the relative specificity of PP2A from phosphoserine/phosphothreonine substrates to phosphotyrosine substrates in an ATP-hydrolysis-dependent manner. Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1 [].PTPA is an α-helical protein which consists of three distinct domains: the core, the linker and the lid. This superfamily consists of the lid domain of PTPA, located usually at the C-terminal.

•

Publication

10339428 | J:55045

First Author:	Ponniah S
Year:	1999
Journal:	Curr Biol
Title:	Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.
Volume:	9
Issue:	10
Pages:	535-8

•

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