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Search results 101 to 193 out of 193 for Ptpn4

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0.026s
Type Details Score
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_20
Specimen Label: euxassay_009725_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_21
Specimen Label: euxassay_009725_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_22
Specimen Label: euxassay_009725_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_23
Specimen Label: euxassay_009725_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_24
Specimen Label: euxassay_009725_24
Detected: true
Specimen Num: 24
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_01
Specimen Label: euxassay_009725_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_02
Specimen Label: euxassay_009725_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_03
Specimen Label: euxassay_009725_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_04
Specimen Label: euxassay_009725_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_05
Specimen Label: euxassay_009725_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_06
Specimen Label: euxassay_009725_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_07
Specimen Label: euxassay_009725_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_08
Specimen Label: euxassay_009725_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_09
Specimen Label: euxassay_009725_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_10
Specimen Label: euxassay_009725_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_11
Specimen Label: euxassay_009725_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_12
Specimen Label: euxassay_009725_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_14
Specimen Label: euxassay_009725_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_15
Specimen Label: euxassay_009725_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_16
Specimen Label: euxassay_009725_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_17
Specimen Label: euxassay_009725_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_18
Specimen Label: euxassay_009725_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_19
Specimen Label: euxassay_009725_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_20
Specimen Label: euxassay_009725_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_21
Specimen Label: euxassay_009725_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_22
Specimen Label: euxassay_009725_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_23
Specimen Label: euxassay_009725_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_24
Specimen Label: euxassay_009725_24
Detected: true
Specimen Num: 24
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_09
Specimen Label: euxassay_009725_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_10
Specimen Label: euxassay_009725_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_11
Specimen Label: euxassay_009725_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_12
Specimen Label: euxassay_009725_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_13
Specimen Label: euxassay_009725_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:4423894
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827520
Age: embryonic day 14.5
Image: euxassay_009725_14
Specimen Label: euxassay_009725_14
Detected: true
Specimen Num: 14
Publication
First Author: Kohda K
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites.
Volume: 110
Issue: 10
Pages: E948-57
Publication
First Author: Hironaka K
Year: 2000
Journal: J Biol Chem
Title: The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits.
Volume: 275
Issue: 21
Pages: 16167-73
Publication
First Author: Young JA
Year: 2008
Journal: Mol Immunol
Title: The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions.
Volume: 45
Issue: 14
Pages: 3756-66
Publication
First Author: Tagawa M
Year: 1994
Journal: Biochem Mol Biol Int
Title: Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat.
Volume: 33
Issue: 6
Pages: 1221-7
Publication
First Author: Proctor WR
Year: 2004
Journal: Alcohol Clin Exp Res
Title: Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice.
Volume: 28
Issue: 9
Pages: 1277-83
Publication
First Author: Espinoza S
Year: 2020
Journal: BMC Biol
Title: Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG.
Volume: 18
Issue: 1
Pages: 164
Publication
First Author: Huang K
Year: 1996
Journal: Oncogene
Title: Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.
Volume: 13
Issue: 7
Pages: 1567-73
Publication
First Author: Alderman PJ
Year: 2024
Journal: Neuron
Title: Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala.
Volume: 112
Issue: 4
Pages: 574-592.e10
Publication
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
Publication
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
Publication      
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
GXD Expression    
Probe: MGI:3834877
Assay Type: Western blot
Annotation Date: 2009-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3834905
Age: postnatal adult
Image: 3
Specimen Label: PTPN3 +/+ PTPN4 +/-
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3834877
Assay Type: Western blot
Annotation Date: 2009-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3834905
Age: postnatal adult
Image: 3
Specimen Label: PTPN3 +/+ PTPN4 -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3834877
Assay Type: Western blot
Annotation Date: 2009-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3834905
Age: postnatal adult
Image: 3
Specimen Label: PTPN3 +/- PTPN4 -/-
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3834877
Assay Type: Western blot
Annotation Date: 2009-03-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3834905
Age: postnatal adult
Image: 3
Specimen Label: PTPN3 -/- PTPN4 +/-
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3834877
Assay Type: Western blot
Annotation Date: 2009-03-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3834905
Age: postnatal adult
Image: 3
Specimen Label: PTPN3 -/- PTPN4 -/-
Detected: false
Specimen Num: 5
Publication
First Author: Huai W
Year: 2015
Journal: J Immunol
Title: Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM.
Volume: 194
Issue: 9
Pages: 4458-65
Publication
First Author: Jing M
Year: 2007
Journal: J Virol
Title: Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins.
Volume: 81
Issue: 5
Pages: 2231-9
Protein Domain
Type: Domain
Description: Tyrosine-protein phosphatase non-receptor type-4 (PTPN4, also known as PTPMEG) is a cytoplasmic protein-tyrosine phosphatase (PTP) thought to play a role in cerebellar function. PTPMEG-knockout mice have impaired memory formation and cerebellar long-term depression []. Tyrosine-protein phosphatase non-receptor type-3 (PTPN3/PTPH1) is a membrane-associated PTP implicated in regulating tyrosine phosphorylation of growth factor receptors, p97 VCP (valosin-containing protein, or Cdc48 in Saccharomyces cerevisiae), and HBV (Hepatitis B Virus) gene expression; it is mutated in a subset of colon cancers []. PTPN3 and PTPN4 contain an N-terminal FERM domain, a middle PDZ domain, and a C-terminal phosphatase domain. Tyrosine-protein phosphatase 1/PTP1 from nematodes is also included in this entry. The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3). The C-lobe/F3 within the FERM domain is part of the PH domain family. Like most other ERM members they have a phosphoinositide-binding site in their FERM domain. The FERM C domain is the third structural domain within the FERM domain. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites [, ].
Publication
First Author: Kitano K
Year: 2006
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304.
Volume: 62
Issue: Pt 4
Pages: 340-5
Publication
First Author: Tepass U
Year: 2009
Journal: Curr Opin Genet Dev
Title: FERM proteins in animal morphogenesis.
Volume: 19
Issue: 4
Pages: 357-67
Protein
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false