Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
200
 |
Fragment?: |
false |
|
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•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2022 |
Journal: |
Mov Disord |
Title: |
Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease. |
Volume: |
37 |
Issue: |
7 |
Pages: |
1454-1464 |
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•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE70123 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
•
•
•
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Publication |
First Author: |
Dhekne HS |
Year: |
2021 |
Journal: |
Life Sci Alliance |
Title: |
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade. |
Volume: |
4 |
Issue: |
5 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Ito G |
Year: |
2016 |
Journal: |
Biochem J |
Title: |
Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. |
Volume: |
473 |
Issue: |
17 |
Pages: |
2671-85 |
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•
•
•
•
•
|
Publication |
First Author: |
Sobu Y |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins. |
Volume: |
118 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Allele |
Name: |
RAB10, member RAS oncogene family; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Publication |
First Author: |
Wang D |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. |
Volume: |
107 |
Issue: |
31 |
Pages: |
13806-11 |
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•
•
•
•
•
|
Publication |
First Author: |
Wang T |
Year: |
2011 |
Journal: |
Dev Cell |
Title: |
Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization. |
Volume: |
21 |
Issue: |
3 |
Pages: |
431-44 |
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•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
•
•
•
•
|
Allele |
Name: |
RAB10, member RAS oncogene family; gene trap XC820, BayGenomics |
Allele Type: |
Gene trapped |
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|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 6; targeted mutation 1, Liqun Luo |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
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•
•
•
•
•
|
Allele |
Name: |
intergenic site 6; targeted mutation 1.1, Liqun Luo |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
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•
•
•
•
•
|
Allele |
Name: |
intergenic site 6; targeted mutation 2, Liqun Luo |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
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•
•
•
•
•
|
Allele |
Name: |
intergenic site 6; targeted mutation 2.1, Liqun Luo |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
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•
•
•
•
•
|
Publication |
First Author: |
Fukuda M |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. |
Volume: |
277 |
Issue: |
14 |
Pages: |
12432-6 |
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•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
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•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs6/Igs6 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs6/Igs6 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs6/Igs6<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuroda TS |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. |
Volume: |
277 |
Issue: |
11 |
Pages: |
9212-8 |
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•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, endonuclease-mediated mutation |
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•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
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•
•
•
•
•
|
Genotype |
Symbol: |
Igs6/Igs6<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Davey JR |
Year: |
2012 |
Journal: |
Traffic |
Title: |
TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. |
Volume: |
13 |
Issue: |
10 |
Pages: |
1429-41 |
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•
•
•
•
•
|
Publication |
First Author: |
Jeng EE |
Year: |
2019 |
Journal: |
Cell Host Microbe |
Title: |
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen. |
Volume: |
26 |
Issue: |
4 |
Pages: |
551-563.e6 |
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•
•
•
•
•
|
Publication |
First Author: |
Gronemeyer T |
Year: |
2013 |
Journal: |
FEBS Lett |
Title: |
Localization of Rab proteins to peroxisomes: a proteomics and immunofluorescence study. |
Volume: |
587 |
Issue: |
4 |
Pages: |
328-38 |
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•
•
•
•
•
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Publication |
First Author: |
Alshafie W |
Year: |
2020 |
Journal: |
J Cell Biol |
Title: |
Regulated resurfacing of a somatostatin receptor storage compartment fine-tunes pituitary secretion. |
Volume: |
219 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs6/Igs6 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Publication |
First Author: |
Dhekne HS |
Year: |
2018 |
Journal: |
Elife |
Title: |
A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. |
Volume: |
7 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tao T |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth. |
Volume: |
294 |
Issue: |
28 |
Pages: |
10954-10968 |
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•
•
•
•
•
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Publication |
First Author: |
Mir R |
Year: |
2018 |
Journal: |
Biochem J |
Title: |
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. |
Volume: |
475 |
Issue: |
11 |
Pages: |
1861-1883 |
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•
•
•
•
•
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Publication |
First Author: |
Kalogeropulou AF |
Year: |
2020 |
Journal: |
Biochem J |
Title: |
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. |
Volume: |
477 |
Issue: |
22 |
Pages: |
4397-4423 |
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•
•
•
•
•
|
Publication |
First Author: |
Malik AU |
Year: |
2021 |
Journal: |
Biochem J |
Title: |
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. |
Volume: |
478 |
Issue: |
3 |
Pages: |
553-578 |
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•
•
•
•
•
|
Publication |
First Author: |
Xu WJ |
Year: |
2019 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression. |
Volume: |
316 |
Issue: |
3 |
Pages: |
L567-L577 |
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•
•
•
•
•
|
Publication |
First Author: |
Dhekne HS |
Year: |
2023 |
Journal: |
Elife |
Title: |
Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase. |
Volume: |
12 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kelly K |
Year: |
2018 |
Journal: |
Exp Neurol |
Title: |
The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition. |
Volume: |
309 |
|
Pages: |
1-13 |
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•
•
•
•
•
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Publication |
First Author: |
Pajarillo E |
Year: |
2023 |
Journal: |
J Biol Chem |
Title: |
The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. |
Volume: |
299 |
Issue: |
7 |
Pages: |
104879 |
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•
•
•
•
•
|
Publication |
First Author: |
Heaton GR |
Year: |
2024 |
Journal: |
bioRxiv |
Title: |
Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant. |
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•
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•
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•
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Publication |
First Author: |
Shi A |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate. |
Volume: |
109 |
Issue: |
35 |
Pages: |
E2306-15 |
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•
•
•
•
•
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Publication |
First Author: |
Li Z |
Year: |
2018 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14. |
Volume: |
314 |
Issue: |
5 |
Pages: |
E478-E493 |
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•
•
•
•
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Publication |
First Author: |
Degrandmaison J |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
In vivo mapping of a GPCR interactome using knockin mice. |
Volume: |
117 |
Issue: |
23 |
Pages: |
13105-13116 |
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•
•
•
•
•
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Publication |
First Author: |
Nirujogi RS |
Year: |
2021 |
Journal: |
Biochem J |
Title: |
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites. |
Volume: |
478 |
Issue: |
2 |
Pages: |
299-326 |
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•
•
•
•
•
|
Publication |
First Author: |
Tasegian A |
Year: |
2021 |
Journal: |
Biochem J |
Title: |
Impact of Type II LRRK2 inhibitors on signaling and mitophagy. |
Volume: |
478 |
Issue: |
19 |
Pages: |
3555-3573 |
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•
•
•
•
•
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Publication |
First Author: |
Ni H |
Year: |
2020 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Nicotine Modulates CTSS (Cathepsin S) Synthesis and Secretion Through Regulating the Autophagy-Lysosomal Machinery in Atherosclerosis. |
Volume: |
40 |
Issue: |
9 |
Pages: |
2054-2069 |
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•
•
•
•
•
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Publication |
First Author: |
Yuan Y |
Year: |
2024 |
Journal: |
Mol Neurodegener |
Title: |
Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation. |
Volume: |
19 |
Issue: |
1 |
Pages: |
47 |
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•
•
•
•
•
|
Publication |
First Author: |
Kadgien CA |
Year: |
2021 |
Journal: |
Mol Brain |
Title: |
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition. |
Volume: |
14 |
Issue: |
1 |
Pages: |
143 |
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•
•
•
•
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Publication |
First Author: |
Hippenmeyer S |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance. |
Volume: |
3 |
Issue: |
3 |
Pages: |
960-7 |
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•
•
•
•
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Publication |
First Author: |
Laukoter S |
Year: |
2020 |
Journal: |
Neuron |
Title: |
Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex. |
Volume: |
107 |
Issue: |
6 |
Pages: |
1160-1179.e9 |
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•
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•
•
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Publication |
First Author: |
Contreras X |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
A genome-wide library of MADM mice for single-cell genetic mosaic analysis. |
Volume: |
35 |
Issue: |
12 |
Pages: |
109274 |
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•
•
•
•
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Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
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•
•
•
•
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Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
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•
•
•
•
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Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
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•
•
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•
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Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
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•
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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