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Search results 101 to 197 out of 197 for Rab18

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 7
Image: g00679 P7
Note: Expression was region specific and scattered.
Specimen Label: g00679 P7
Detected: true
Specimen Num: 3
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 42
Image: g00679 Adult
Specimen Label: g00679 Adult
Detected: true
Specimen Num: 4
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4844340
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1636715
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:4848327
Age: embryonic day 9.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:4844340
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1636717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4848327
Age: embryonic day 10.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 7
Image: g00679 P7
Specimen Label: g00679 P7
Detected: true
Specimen Num: 3
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 42
Image: g00679 Adult
Specimen Label: g00679 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945210
Age: embryonic day 11.5
Image: g00679 E11.5
Specimen Label: g00679 E11.5
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 7
Image: g00679 P7
Specimen Label: g00679 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 42
Image: g00679 Adult
Specimen Label: g00679 Adult
Detected: true
Specimen Num: 4
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4844340
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848327
Age: embryonic day 10.5
Note: Staining is present in the otic pit.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:1002760
Assay Type: RNA in situ
Annotation Date: 2024-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7623583
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7778403
Assay Type: Immunohistochemistry
Annotation Date: 2024-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7779628
Age: embryonic day 14.5
Image: 1E E14.5
Specimen Label: 1E E14.5
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 7
Image: g00679 P7
Note: Expression was region specific and scattered.
Specimen Label: g00679 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 42
Image: g00679 Adult
Specimen Label: g00679 Adult
Detected: true
Specimen Num: 4
•
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945210
Age: embryonic day 15.5
Image: g00679 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00679 E15.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 7
Image: g00679 P7
Specimen Label: g00679 P7
Detected: true
Specimen Num: 3
•
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 42
Image: g00679 Adult
Note: Expression was region specific and scattered.
Specimen Label: g00679 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945210
Age: embryonic day 15.5
Image: g00679 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00679 E15.5
Detected: true
Specimen Num: 2
•
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•
GXD Expression
GXD Expression
 
Probe: MGI:7778403
Assay Type: Immunohistochemistry
Annotation Date: 2024-11-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7779628
Age: embryonic day 17.5
Image: 1E E17.5
Specimen Label: 1E E17.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7778403
Assay Type: Immunohistochemistry
Annotation Date: 2024-11-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7779628
Age: postnatal day 0
Image: 1E P0
Specimen Label: 1E P0
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945210
Age: embryonic day 15.5
Image: g00679 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00679 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 7
Image: g00679 P7
Note: Expression was region specific and scattered.
Specimen Label: g00679 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945210
Age: postnatal day 42
Image: g00679 Adult
Note: Expression was region specific and scattered.
Specimen Label: g00679 Adult
Detected: true
Specimen Num: 4
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:7778406
Assay Type: RNA in situ
Annotation Date: 2024-11-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3671622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7779625
Age: embryonic day 14.5
Image: 1C E14.5
Specimen Label: 1C E14.5
Detected: true
Specimen Num: 1
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Publication
8583936 | J:30269
 
First Author: Murphy C
Year: 1995
Journal: Methods Enzymol
Title: Expression of Rab proteins during mouse embryonic development.
Volume: 257
Pages: 324-32
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Publication
12368914 | J:79322
First Author: Wilson SM
Year: 2002
Journal: Nat Genet
Title: Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease.
Volume: 32
Issue: 3
Pages: 420-5
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Publication
1555775 | J:24144
First Author: Chavrier P
Year: 1992
Journal: Gene
Title: The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.
Volume: 112
Issue: 2
Pages: 261-4
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Publication
36220081 | J:330212
First Author: Wang S
Year: 2022
Journal: Dev Cell
Title: KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice.
Volume: 57
Issue: 19
Pages: 2273-2289.e11
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Publication
36288084 | J:330827
   
First Author: Yoo D
Year: 2022
Journal: Elife
Title: Little skate genome provides insights into genetic programs essential for limb-based locomotion.
Volume: 11
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Publication
15582152 | J:102103
First Author: Jensen P
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A neurogenomics approach to gene expression analysis in the developing brain.
Volume: 132
Issue: 2
Pages: 116-27
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
26063829 | J:359820
First Author: Handley MT
Year: 2015
Journal: Open Biol
Title: Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation.
Volume: 5
Issue: 6
Pages: 150047
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Allele
Rab18<m1Hongc> | MGI:5698701
Name: RAB18, member RAS oncogene family; mutation 1, Chen-Jee Hong
Allele Type: Chemically induced (ENU)
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Rab18/Rab18
Background: C57BL/6J-Rab18
Zygosity: hm
Has Mutant Allele: true
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Interaction Experiment
Kiss RS (2023)
Description: Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.
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Allele
Rab18<Gt(EUCE0233a03)Hmgu> | MGI:4369232
Name: RAB18, member RAS oncogene family; gene trap EUCE0233a03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Attribute String: Null/knockout
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Publication
37774976 | -
First Author: Kiss RS
Year: 2023
Journal: J Biol Chem
Title: Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.
Volume: 299
Issue: 11
Pages: 105295
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Genotype
Genotype
Symbol: Rab18/Rab18
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110718 | Warburg micro syndrome 3
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Strain
MGI:5698702 | C57BL/6J-Rab18<m1Hongc>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Protein
Q80UJ7
Organism: Mus musculus/domesticus
Length: 981  
Fragment?: false
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Protein
Q8BMG7
Organism: Mus musculus/domesticus
Length: 1366  
Fragment?: false
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Protein
E9QKE4
Organism: Mus musculus/domesticus
Length: 1387  
Fragment?: false
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Protein
A0A1D5RLG3
Organism: Mus musculus/domesticus
Length: 988  
Fragment?: false
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Protein
A0A0A6YWM5
Organism: Mus musculus/domesticus
Length: 1367  
Fragment?: false
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Protein
Q3UYK8
Organism: Mus musculus/domesticus
Length: 982  
Fragment?: false
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Publication
30970241 | J:284991
First Author: Li D
Year: 2019
Journal: Cell Rep
Title: The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.
Volume: 27
Issue: 2
Pages: 343-358.e5
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Protein Domain
IPR026147 | Rab3GAP1_conserved
Type: Domain
Description: This entry represents a conserved domain found in the Rab3 GTPase-activating protein catalytic subunit (Rab3GAP1).Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Domain
IPR026059 | Rab3GAP2
Type: Family
Description: This family represents the regulatory subunit of the Rab3GAP complex, also known as Rab3GAP2. Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Domain
IPR032839 | RAB3GAP_N
Type: Domain
Description: This family includes the N terminus of the Rab3 GTPase-activating protein (GAP) non-catalytic subunit.Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Domain
IPR029257 | RAB3GAP2_C
Type: Domain
Description: This entry represents the C terminus of the Rab3 GTPase-activating protein non-catalytic subunit.Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Domain
IPR045698 | Rab3GAP1_C
Type: Domain
Description: This entry represents the C-terminal domain found in the Rab3 GTPase-activating protein catalytic subunit (Rab3GAP1) predominantly in animals.Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Domain
IPR045700 | Rab3GAP1
Type: Family
Description: Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein
Q8BYZ6
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
Q3UEY3
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: true
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Publication
15696165 | -
First Author: Aligianis IA
Year: 2005
Journal: Nat Genet
Title: Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome.
Volume: 37
Issue: 3
Pages: 221-3
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Publication
9030515 | -
First Author: Fukui K
Year: 1997
Journal: J Biol Chem
Title: Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins.
Volume: 272
Issue: 8
Pages: 4655-8
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Publication
9852129 | -
First Author: Oishi H
Year: 1998
Journal: J Biol Chem
Title: Localization of the Rab3 small G protein regulators in nerve terminals and their involvement in Ca2+-dependent exocytosis.
Volume: 273
Issue: 51
Pages: 34580-5
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Publication
10859313 | -
First Author: Clabecq A
Year: 2000
Journal: J Biol Chem
Title: Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP.
Volume: 275
Issue: 41
Pages: 31786-91
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Publication
32248620 | -
First Author: Takáts S
Year: 2021
Journal: FEBS J
Title: The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I.
Volume: 288
Issue: 1
Pages: 190-211
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Publication
25476608 | J:315009
 
First Author: Park AK
Year: 2014
Journal: BMC Genet
Title: Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice.
Volume: 15
Pages: 135
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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