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Search results 101 to 197 out of 197 for Rab21

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Type Details Score
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
36683567 | J:333955
First Author: Shikanai M
Year: 2023
Journal: EMBO Rep
Title: Rab21 regulates caveolin-1-mediated endocytic trafficking to promote immature neurite pruning.
Volume: 24
Issue: 3
Pages: e54701
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Publication
25648148 | -
First Author: Jean S
Year: 2015
Journal: EMBO Rep
Title: Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.
Volume: 16
Issue: 3
Pages: 297-311
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Publication
25821953 | -
First Author: Sohn YS
Year: 2015
Journal: PLoS One
Title: Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22.
Volume: 10
Issue: 3
Pages: e0118683
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Publication
18804435 | -
First Author: Pellinen T
Year: 2008
Journal: Dev Cell
Title: Integrin trafficking regulated by Rab21 is necessary for cytokinesis.
Volume: 15
Issue: 3
Pages: 371-85
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Publication
22648168 | -
First Author: Jean S
Year: 2012
Journal: Mol Biol Cell
Title: Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.
Volume: 23
Issue: 14
Pages: 2723-40
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Protein Domain
IPR041545 | DUF5601
Type: Domain
Description: This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature [].
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Publication
12554688 | -
First Author: Senderek J
Year: 2003
Journal: Hum Mol Genet
Title: Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15.
Volume: 12
Issue: 3
Pages: 349-56
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Protein Domain
IPR022096 | SBF1/SBF2
Type: Domain
Description: This domain is found in eukaryotes, and is approximately 220 amino acids in length. It is found in association with , . It is found is the middle region of SBF1 and SBF2, members of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease []. SBF2 is a guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 [, ].
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Publication
22705394 | J:187508
First Author: Burgo A
Year: 2012
Journal: Dev Cell
Title: A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery.
Volume: 23
Issue: 1
Pages: 166-80
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Publication
26436690 | J:227648
First Author: Alanko J
Year: 2015
Journal: Nat Cell Biol
Title: Integrin endosomal signalling suppresses anoikis.
Volume: 17
Issue: 11
Pages: 1412-21
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Protein
Q8R0A7
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
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Protein
Q3TA40
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein Domain
IPR041321 | Lpg0393_HBD
Type: Domain
Description: Lpg0393 is a Legionella pneumophila effector protein. Structure analysis reveals that it has two domains, the N-terminal domain is a Vps9-like domain, which is structurally most similar to the catalytic core of human Rabex-5 that activates the endosomal Rab proteins Rab5, Rab21 and Rab22. The C-terminal domain is a helical bundle domain. The C-terminal helical bundle of Lpg0393 corresponds to the N-terminal helical bundle of Rabex-5, it lacks an obvious region that corresponds to the membrane-binding motif of Rabex-5. One possibility may be that Lpg0393 localization to endosomes depends on an unknown Legionella effector [].
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Publication
17450153 | -
First Author: Delprato A
Year: 2007
Journal: Nat Struct Mol Biol
Title: Structural basis for Rab GTPase activation by VPS9 domain exchange factors.
Volume: 14
Issue: 5
Pages: 406-12
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Publication
25661869 | J:220987
First Author: Yatsu A
Year: 2015
Journal: Biol Open
Title: Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.
Volume: 4
Issue: 3
Pages: 267-75
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Protein Domain
IPR037191 | VPS9_dom_sf
Type: Homologous_superfamily
Description: Rab proteins form a family of signal-transducing GTPases that cycle between active GTP-bound and inactive GDP-bound forms. The Rab5 GTPase is an essential regulator of endocytosis and endosome biogenesis. Rab5 is activated by GDP-GTP exchange factors (GEFs) that contain a VPS9 domain and generate the Rab5-GTP complex []. The VPS9 domain catalyses nucleotide exchange on Rab5 or the yeast homologue VPS21 []. The domain has a length of ~140 residues and forms the central part of the yeast VPS9 (vacuolar protein sorting-associated) protein, which acts as a GEF for VPS21. Some domains which can occur in combination with the VPS9 domain are CUE, A20-type zinc finger, Ras-associating (RA), SH2, RCC1, DH, PH, rasGAP, MORN and ankyrin repeat.Structurally, the VPS9 domain adopts a layered fold of six alpha helices. Conserved residues from the fourth and sixth helices and theloops N-terminal to these helices form the surface that interacts with Rab5and Rab21 [].
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Protein
F7ADQ2
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: true
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Protein
F7ADT6
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: true
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Protein
A0A0U1RPT7
Organism: Mus musculus/domesticus
Length: 388  
Fragment?: false
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Protein
A0A0R4J2C4
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Publication
15339665 | -
First Author: Delprato A
Year: 2004
Journal: Cell
Title: Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5.
Volume: 118
Issue: 5
Pages: 607-17
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Publication
16330212 | -
First Author: Carney DS
Year: 2006
Journal: Trends Cell Biol
Title: Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons.
Volume: 16
Issue: 1
Pages: 27-35
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Protein
Q60I26
Organism: Mus musculus/domesticus
Length: 952  
Fragment?: false
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Protein
Q8C190
Organism: Mus musculus/domesticus
Length: 649  
Fragment?: false
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Protein
Q8VDI6
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
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Protein
A0A140LIA6
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
D3Z2L2
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
D3YWB4
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
A0A286YCR5
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
Q3U280
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
A0A0R4J1X4
Organism: Mus musculus/domesticus
Length: 952  
Fragment?: false
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Protein Domain
IPR003123 | VPS9
Type: Domain
Description: Rab proteins form a family of signal-transducing GTPases that cycle betweenactive GTP-bound and inactive GDP-bound forms. The Rab5 GTPase is an essentialregulator of endocytosis and endosome biogenesis. Rab5 is activated by GDP-GTPexchange factors (GEFs) that contain a VPS9 domain and generate the Rab5-GTPcomplex []. The VPS9 domain catalyzes nucleotide exchange on Rab5 or theyeast homologue VPS21. The domain has a length of ~140 residues and forms thecentral part of the yeast VPS9 (vacuolar protein sorting-associated) protein,which acts as a GEF for VPS21. Some domains which canoccur in combinationwith the VPS9 domain are CUE, A20-type zinc finger, Ras-associating (RA), SH2,RCC1, DH, PH, rasGAP, MORN and ankyrin repeat.Structurally, the VPS9 domain adopts a layered fold of six alpha helices. Conserved residues from the fourth and sixth helices and theloops N-terminal to these helices form the surface that interacts with Rab5and Rab21 [].Some proteins known to contain a VPS9 domain:Fungal Vacuolar Protein Sorting-associated protein VPS9, a guaninenucleotide exchange factor for the Rab-like GTPase VPS21. VPS9 is neededfor the transport of proteins from biosynthetic and endocytic pathways intothe vacuole.Mammalian Rab5 GDP/GTP exchange factor or Rabex-5 (Rababtin-5 associatedexchange factor for Rab5), catalyzes nucleotide exchange on RAB5A. Rabex-5promotes endocytic membrane fusion and is involved in membrane traffickingof recycling endosomes.Mammalian Ras and Rab interactor 1 (RIN1), 2 (RIN2) and 3 (RIN3).Mammalian alsin or Amyotrophic Lateral Sclerosis protein 2 (ALS2).Different juvenile-onset forms of neurodegenerative diseases (ALS2, JPLS,IAHSP) are caused by mutations in the ALS2 gene, which result in truncatedalsin lacking the C-terminal part of the VPS9 domain.Fruit fly protein sprint, which is a RIN homologue.Caenorhabditis elegans RME-6 protein, which is conserved among metazoans.
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Protein
Q9JM13
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
Q6PAR5
Organism: Mus musculus/domesticus
Length: 1458  
Fragment?: false
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Protein
Q3UMR0
Organism: Mus musculus/domesticus
Length: 1048  
Fragment?: false
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Protein
Q80UW3
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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Protein
Q3TBT4
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
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Protein
Q3TR60
Organism: Mus musculus/domesticus
Length: 649  
Fragment?: true
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Protein
Q6PDX1
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
Q3U8Y2
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
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Protein
Q3TAJ7
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: true
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Protein
Q3U461
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
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Protein
C4TGC3
Organism: Mus musculus/domesticus
Length: 1048  
Fragment?: false
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Protein
Q3U332
Organism: Mus musculus/domesticus
Length: 900  
Fragment?: false
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Protein
F6S251
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
F6QG63
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Protein
P59729
Organism: Mus musculus/domesticus
Length: 980  
Fragment?: false
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Protein
Q3TM19
Organism: Mus musculus/domesticus
Length: 980  
Fragment?: false
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Protein
Q3U3Y6
Organism: Mus musculus/domesticus
Length: 980  
Fragment?: false
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Protein
Q80WA0
Organism: Mus musculus/domesticus
Length: 980  
Fragment?: false
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Protein
Q920R0
Organism: Mus musculus/domesticus
Length: 1651  
Fragment?: false
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Protein
Q9D684
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
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Protein
Q921Q7
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
F8WGD2
Organism: Mus musculus/domesticus
Length: 858  
Fragment?: false
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Protein
A0A2C9F2A2
Organism: Mus musculus/domesticus
Length: 774  
Fragment?: false
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Publication
20937701 | -
First Author: Yoshimura S
Year: 2010
Journal: J Cell Biol
Title: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
Volume: 191
Issue: 2
Pages: 367-81
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Protein
Q8BX53
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein
Q6NX80
Organism: Mus musculus/domesticus
Length: 668  
Fragment?: false
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Protein
Q6ZPE2
Organism: Mus musculus/domesticus
Length: 1867  
Fragment?: false
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Protein
E9PXF8
Organism: Mus musculus/domesticus
Length: 1872  
Fragment?: false
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Protein
E9Q0D4
Organism: Mus musculus/domesticus
Length: 1826  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom