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Search results 101 to 172 out of 172 for Rab32

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Protein
A0A140LHP1
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
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Protein
Q9CRG4
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: true
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Publication
8896559 | -
First Author: Oh J
Year: 1996
Journal: Nat Genet
Title: Positional cloning of a gene for Hermansky-Pudlak syndrome, a disorder of cytoplasmic organelles.
Volume: 14
Issue: 3
Pages: 300-6
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Protein Domain
IPR037745 | SGSM1/2
Type: Domain
Description: Small G-protein signalling modulator 1/2 (also known as RUTBC2/1) bind to Rab9A via their Pleckstrin homology (PH) domain [, ]. RUTBC1 stimulates GTP hydrolysis by Rab32 and Rab33B [], while RUTBC2 appears to be a GAP for Rab36, Rab9A and associated proteins controling the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi [, , ]. This entry represents the PH domain of RUTBC1/2.
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Protein Domain
IPR021935 | SGSM1/2_RBD
Type: Domain
Description: This domain adopts a PH-like fold. It has been called the Rab-binding domain (RBD) []. Small G-protein signalling modulator 1/2 (also known as RUTBC2/1) bind to Rab9A via their Pleckstrin homology (PH) domain [, ]. RUTBC1 stimulates GTP hydrolysis by Rab32 and Rab33B [], while RUTBC2 appears to be a GAP for Rab36, Rab9A and associated proteins controling the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi [, , ].
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Publication
37640963 | J:339869
     
First Author: Lian H
Year: 2023
Journal: Nat Microbiol
Title: Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella.
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Publication
17509819 | J:125105
First Author: Yang H
Year: 2007
Journal: Genomics
Title: Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.
Volume: 90
Issue: 2
Pages: 249-60
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Protein
O08983
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: false
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Protein
Q3U309
Organism: Mus musculus/domesticus
Length: 712  
Fragment?: false
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Protein
Q5FWJ4
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: false
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Protein
E9Q045
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
Q8CD56
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
E9PYL0
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
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Protein
Q80VD7
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: true
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Protein
Q3TBI2
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Protein
A0A0R4J062
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: false
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Publication
23084991 | -
First Author: Gerondopoulos A
Year: 2012
Journal: Curr Biol
Title: BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.
Volume: 22
Issue: 22
Pages: 2135-9
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Publication
21291502 | J:196257
First Author: Beaumont KA
Year: 2011
Journal: Traffic
Title: The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking.
Volume: 12
Issue: 5
Pages: 627-43
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Publication
17671165 | J:128282
First Author: Lopes VS
Year: 2007
Journal: Mol Biol Cell
Title: Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis.
Volume: 18
Issue: 10
Pages: 3914-27
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Protein
Q99KG7
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
Q3TAF8
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
Q541V2
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: true
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Protein
Q6P568
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein Domain
IPR043989 | CCZ1/INTU/HSP4_longin_3
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the third Longin domain found in CCZ1, INTU and HPS4 proteins.
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Protein Domain
IPR043987 | CCZ1/INTU/HSP4_longin_1
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the first Longin domain found in INTU, CCZ1 and HPS4.
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Protein Domain
IPR043988 | CCZ1/INTU_longin_2
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the second Longin domain found in INTU and CCZ1 proteins.
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Protein Domain
IPR043972 | FUZ/MON1/HPS1_longin_1
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the first Longin domain found in FUZ, MON1 and HPS1 proteins.
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Protein Domain
IPR043970 | FUZ/MON1/HPS1_longin_3
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the third Longin domain of FUZ, MON1 and HPS1 proteins.
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Protein Domain
IPR043971 | FUZ/MON1/HPS1_longin_2
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the second Longin domain found in FUZ, MON1 and HPS1 proteins.
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Publication
27158779 | J:243791
First Author: Toriyama M
Year: 2016
Journal: Nat Genet
Title: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.
Volume: 48
Issue: 6
Pages: 648-56
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Publication
19767740 | J:158243
First Author: Gray RS
Year: 2009
Journal: Nat Cell Biol
Title: The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development.
Volume: 11
Issue: 10
Pages: 1225-32
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Publication
17075139 | -
First Author: Kinch LN
Year: 2006
Journal: Protein Sci
Title: Longin-like folds identified in CHiPS and DUF254 proteins: vesicle trafficking complexes conserved in eukaryotic evolution.
Volume: 15
Issue: 11
Pages: 2669-74
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Publication
28051187 | -
 
First Author: Kiontke S
Year: 2017
Journal: Nat Commun
Title: Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.
Volume: 8
Pages: 14034
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Publication
31562761 | -
First Author: Sanchez-Pulido L
Year: 2020
Journal: Bioinformatics
Title: Hexa-Longin domain scaffolds for inter-Rab signalling.
Volume: 36
Issue: 4
Pages: 990-993
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Protein
Q8C1Y8
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q6PDG8
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Protein
Q3UYI6
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q8BMQ8
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
A0A0R4J0D5
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Protein
A0A140LIC9
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Protein
A0A140LJD3
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
E9QL29
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
A0A140LI55
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
A0A140LIH3
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Protein
A0A0R4J2D4
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q9CZE3
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
Q8QZZ8
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q91YQ1
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
Q5FW76
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
A0A140LHK2
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
A0A140LI92
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
Q0PD23
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
A0A140LI68
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
Q0PD25
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
A0A140LJ73
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
Q3TW01
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
A0A0N4SUY7
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein
E9QLQ7
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
Q059U7
Organism: Mus musculus/domesticus
Length: 942  
Fragment?: false
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Protein
Q8BPQ7
Organism: Mus musculus/domesticus
Length: 1093  
Fragment?: false
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Protein
Q80U12
Organism: Mus musculus/domesticus
Length: 1005  
Fragment?: false
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Protein
D3Z7V4
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Q3TDT4
Organism: Mus musculus/domesticus
Length: 1031  
Fragment?: true
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Protein
D3YUT7
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: true
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Protein
B2RQR5
Organism: Mus musculus/domesticus
Length: 1093  
Fragment?: false
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Protein
Q8BYH7
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: false
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Protein
Q9CXF4
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
Q3U5C0
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: false
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Protein
Q3UDU6
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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Protein
Q4TVN0
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
Q7TPU5
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
I6L974
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom