Type |
Details |
Score |
Protein Domain |
Type: |
Domain |
Description: |
The RH2 (RILP homology 2) Rab-binding domain is found in the following animalproteins [, , ]:Rab interacting lysosomal proteins (RILP), which interacts with Rab7,Rab34, and Rab36.RILP-like 1 (RILP-L1), which interacts with Rab12, Rab34, and Rab36.RILP-like 2 (RILP-L2), which interacts with Rab34 and Rab36.JNK-interacting protein 3 (JIP3), which interacts with Rab36 alone.JNK-interacting protein 4 (JIP4), which interacts with Rab36 alone.The RH2 domain is folded into a long helix alpha1 and a short helix alpha2connected by a very tight loop. The RH2 domain forms atightly associated four helices homodimer in which both helices alpha1 andalpha2 are involved in dimerization. Such a homodimer binds to two separateRab-GTP molecules on opposite sides, with both helices involved in theinteraction with Rab. In the complex interface, although each Rab-GTPinteracts with both helices of the RH2 domain, these two helices arecontributed by two different molecules, with helix alpha1 coming from oneprotomer and helix alpha2 from the other protomer [].The entry represents the entire RH2 domain. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
196
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu M |
Year: |
2005 |
Journal: |
EMBO J |
Title: |
Structural basis for recruitment of RILP by small GTPase Rab7. |
Volume: |
24 |
Issue: |
8 |
Pages: |
1491-501 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
775
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
369
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
406
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
197
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
369
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
827
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1164
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1169
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
901
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1169
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1321
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1337
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1337
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1300
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1306
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1337
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1300
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1328
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1320
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1345
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1337
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1064
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1064
 |
Fragment?: |
false |
|
•
•
•
•
•
|