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Search results 101 to 148 out of 148 for Rab39b

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Type Details Score
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
36761179 | J:333115
 
First Author: Wang Z
Year: 2023
Journal: Front Aging Neurosci
Title: Loss of RAB39B does not alter MPTP-induced Parkinson's disease-like phenotypes in mice.
Volume: 15
Pages: 1087823
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Allele
Rab39b<em6Lutzy> | MGI:6879445
Name: RAB39B, member RAS oncogene family; endonuclease-mediated mutation 6, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Allele
Rab39b<em1Smoc> | MGI:7291950
Name: RAB39B, member RAS oncogene family; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
25434005 | -
First Author: Wilson GR
Year: 2014
Journal: Am J Hum Genet
Title: Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.
Volume: 95
Issue: 6
Pages: 729-35
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Strain
MGI:7718223 | C57BL/6JSmoc-Rab39b<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Rab39b/?
Background: B6N.Cg-Rab39b
Zygosity: ot
Has Mutant Allele: true
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DO Term
DOID:0112059 | non-syndromic X-linked intellectual disability 72
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DO Term
DOID:0111781 | Waisman syndrome
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Allele
Tg(Rab39b-cre)TL73Gsat | MGI:5435482
Name: transgene insertion TL73, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5435803 | STOCK Tg(Rab39b-cre)TL73Gsat/Mmucd
Attribute String: transgenic, mutant stock
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Publication
27103069 | J:233688
First Author: Sellier C
Year: 2016
Journal: EMBO J
Title: Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
Volume: 35
Issue: 12
Pages: 1276-97
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Publication
11856727 | J:83919
First Author: Fukuda M
Year: 2002
Journal: J Biol Chem
Title: Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.
Volume: 277
Issue: 14
Pages: 12432-6
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Publication
24349490 | J:225172
First Author: Seto S
Year: 2013
Journal: PLoS One
Title: Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.
Volume: 8
Issue: 12
Pages: e83324
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Publication
21255211 | -
First Author: Seto S
Year: 2011
Journal: Traffic
Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.
Volume: 12
Issue: 4
Pages: 407-20
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Publication
19833722 | -
First Author: Becker CE
Year: 2009
Journal: J Biol Chem
Title: Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion.
Volume: 284
Issue: 50
Pages: 34531-7
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Protein Domain
IPR041818 | Rab39
Type: Family
Description: This entry includes Ras-related proteins Rab39a and Rab39b. Rab39a is involved in phagosome maturation, inflammatory activation and neuritogenesis [, , ]. It also interacts with PI3K and negatively regulates the LPS-induced autophagy in macrophages []. Rab39b has also been found to be involved in autophagy and neuritogenesis []. Rab39a is widely expressed, while Rab39b is enriched in the brain []. Rabs are regulated by GTPase activating proteins (GAPs), which interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins [, ].
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Publication
16923123 | J:123368
First Author: Itoh T
Year: 2006
Journal: Genes Cells
Title: Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
Volume: 11
Issue: 9
Pages: 1023-37
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Publication
11773082 | J:75312
First Author: Kuroda TS
Year: 2002
Journal: J Biol Chem
Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Volume: 277
Issue: 11
Pages: 9212-8
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Publication
12578829 | J:83108
First Author: Fukuda M
Year: 2003
Journal: J Biol Chem
Title: Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
Volume: 278
Issue: 17
Pages: 15373-80
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Protein
Q6DFW0
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
Q8K3B2
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
A2ANZ2
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Publication
21944778 | -
First Author: DeJesus-Hernandez M
Year: 2011
Journal: Neuron
Title: Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS.
Volume: 72
Issue: 2
Pages: 245-56
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Publication
32303654 | -
First Author: Tang D
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a.
Volume: 117
Issue: 18
Pages: 9876-9883
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Publication
34297726 | -
First Author: Nörpel J
Year: 2021
Journal: PLoS Biol
Title: Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture.
Volume: 19
Issue: 7
Pages: e3001344
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Protein Domain
IPR027819 | C9orf72
Type: Family
Description: The entry includes Guanine nucleotide exchange factor C9orf72 protein, a component of the C9orf72-SMCR8 complex, which has guanine nucleotide exchange factor activity []and regulates autophagy [, ]. The C9orf72 protein is proposed to be a catalytic component for the exchange of GDP to GTP and promoting autophagosome maturation by converting inactive GDP-bound RAB8A and RAB39B into their active forms []. Defects in the C9orf72 gene are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) which is an autosomal dominant neurodegenerative disorder. The disorder is caused by a large expansion of a GGGGCC hexanucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci []. This family is found in eukaryotes.C9orf72 contains the DENN domain, which forms a heart-shaped structure (), with the N-terminal residues forming one lobe and the C-terminal residues forming the second one. The tripartite DENN (after differentially expressed in neoplastic versus normal cells) domain is found in several proteins that share common structural features and have been shown to be guanine nucleotide exchange factors (GEFs) for Rab GTPases, which are regulators of practically all membrane trafficking events in eukaryotes [, ].
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Publication
27193190 | J:240578
First Author: Sullivan PM
Year: 2016
Journal: Acta Neuropathol Commun
Title: The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.
Volume: 4
Issue: 1
Pages: 51
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Publication
28195531 | -
   
First Author: Jung J
Year: 2017
Journal: Elife
Title: Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
Volume: 6
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Protein
Q8BHD0
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
Q8BHC1
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Protein
Q0PD15
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Publication
10196122 | -
First Author: Dumas JJ
Year: 1999
Journal: Structure
Title: Structural basis of activation and GTP hydrolysis in Rab proteins.
Volume: 7
Issue: 4
Pages: 413-23
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Publication
22065758 | -
First Author: Wu X
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.
Volume: 108
Issue: 46
Pages: 18672-7
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Publication
11387043 | -
First Author: Stenmark H
Year: 2001
Journal: Genome Biol
Title: The Rab GTPase family.
Volume: 2
Issue: 5
Pages: REVIEWS3007
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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