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Search results 101 to 200 out of 331 for Ralb

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Type Details Score
GXD Expression    
Probe: MGI:5052283
Assay Type: RNA in situ
Annotation Date: 2011-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287324
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5052284
Age: embryonic day 16.5
Specimen Label: Not shown, E16.5
Detected: true
Specimen Num: 11
GXD Expression
Probe: MGI:5052283
Assay Type: RNA in situ
Annotation Date: 2011-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5052284
Age: embryonic day 12.5
Image: 2B
Note: Stronger expression is in the paraolivary nucleus and future CA3 region of the hippocampus.
Specimen Label: 2B
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5052283
Assay Type: RNA in situ
Annotation Date: 2011-08-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5052284
Age: embryonic day 16.5
Image: 2E
Note: Expression is in the paraolivary nucleus.
Specimen Label: 2E
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:5052283
Assay Type: RNA in situ
Annotation Date: 2011-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5052284
Age: embryonic day 12.5
Note: Stronger expression is in the paraolivary nucleus and future CA3 region of the hippocampus.
Specimen Label: Not shown, E12.5
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:5052283
Assay Type: RNA in situ
Annotation Date: 2011-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5052284
Age: embryonic day 14.5
Note: Expression is in the paraolivary nucleus.
Specimen Label: Not shown, E14.5
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:5052283
Assay Type: RNA in situ
Annotation Date: 2011-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5052284
Age: embryonic day 16.5
Note: Expression is in the paraolivary nucleus.
Specimen Label: Not shown, E16.5
Detected: true
Specimen Num: 11
Publication    
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, v-ral simian leukemia viral oncogene homolog B (ras related), clone MGC: 11937, mRNA, complete cds
Pages: BC006907
Publication    
First Author: Nászai M
Year: 2021
Journal: Elife
Title: RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.
Volume: 10
Publication
First Author: Shao H
Year: 2000
Journal: J Biol Chem
Title: A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras.
Volume: 275
Issue: 35
Pages: 26914-24
Publication
First Author: DeGeer J
Year: 2022
Journal: Cell Rep
Title: Ral GTPases are critical regulators of spinal cord myelination and homeostasis.
Volume: 40
Issue: 13
Pages: 111413
Publication
First Author: Oeschger FM
Year: 2012
Journal: Cereb Cortex
Title: Gene expression analysis of the embryonic subplate.
Volume: 22
Issue: 6
Pages: 1343-59
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Iouzalen N
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Identification and characterization in Xenopus of XsmgGDS, a RalB binding protein.
Volume: 250
Issue: 2
Pages: 359-63
Publication
First Author: Bodemann BO
Year: 2011
Journal: Cell
Title: RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.
Volume: 144
Issue: 2
Pages: 253-67
Publication
First Author: Moreau J
Year: 1999
Journal: Dev Biol
Title: Characterization of Xenopus RalB and its involvement in F-actin control during early development.
Volume: 209
Issue: 2
Pages: 268-81
Publication
First Author: Pomeroy EJ
Year: 2017
Journal: Oncogene
Title: Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.
Volume: 36
Issue: 23
Pages: 3263-3273
Publication
First Author: Vasseur R
Year: 2015
Journal: Biochim Biophys Acta
Title: The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways.
Volume: 1849
Issue: 12
Pages: 1375-84
Publication
First Author: Simicek M
Year: 2013
Journal: Nat Cell Biol
Title: The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Volume: 15
Issue: 10
Pages: 1220-30
Publication
First Author: Lebreton S
Year: 2004
Journal: Mech Dev
Title: RLIP mediates downstream signalling from RalB to the actin cytoskeleton during Xenopus early development.
Volume: 121
Issue: 12
Pages: 1481-94
Publication
First Author: Chien Y
Year: 2006
Journal: Cell
Title: RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Volume: 127
Issue: 1
Pages: 157-70
Protein Domain
Type: Family
Description: Ral GTPase-activating protein subunit beta (RALGAPB) is a non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB [].
Publication
First Author: Albright CF
Year: 1993
Journal: EMBO J
Title: Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
Volume: 12
Issue: 1
Pages: 339-47
Publication
First Author: Colicelli J
Year: 2004
Journal: Sci STKE
Title: Human RAS superfamily proteins and related GTPases.
Volume: 2004
Issue: 250
Pages: RE13
Publication
First Author: Lim KH
Year: 2005
Journal: Cancer Cell
Title: Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
Volume: 7
Issue: 6
Pages: 533-45
Protein Domain
Type: Family
Description: Ral protein family, including RALA and RALB, belongs to the RAS family of small GTPases. Like other RAS GTPases, Ral proteins function as molecular switches alternating between inactive GDP-bound and active GT-bound states [].In humans, RALA and RALB are activated in tumour-derived cell lines. RALA severely impairs the anchorage-independent proliferation of cancer cell lines [], while RALB is required to suppress apoptotic checkpoint activation and is essential for the survival of a variety of tumour-derived cell lines []. RALA and RALB share the same effector molecules, such as SEC5 and EXO84. However, they seem to function in distinct but inter-related biological processes. RALA regulates the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 []. The RALB/Sec5 effector complex is involved in the TBK1-dependent innate immune signaling [], while the interaction between PALB and EXO84 promotes the assembly of catalytically active ULK1 and the beclin-1-VPS34 autophagy initiation complex []. This entry also includes Xenopus RalA and RalB. RalB regulates the actin cytoskeleton during the early development and affects gastrulation [].
Publication
First Author: Shi CS
Year: 2012
Journal: Nat Immunol
Title: Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction.
Volume: 13
Issue: 3
Pages: 255-63
Publication
First Author: Moskalenko S
Year: 2003
Journal: J Biol Chem
Title: Ral GTPases regulate exocyst assembly through dual subunit interactions.
Volume: 278
Issue: 51
Pages: 51743-8
Publication
First Author: Balasubramanian N
Year: 2010
Journal: Curr Biol
Title: RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling.
Volume: 20
Issue: 1
Pages: 75-9
Publication
First Author: Nishimura A
Year: 2013
Journal: Mol Cell Biol
Title: Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding.
Volume: 33
Issue: 7
Pages: 1417-29
Publication
First Author: Shirakawa R
Year: 2009
Journal: J Biol Chem
Title: Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.
Volume: 284
Issue: 32
Pages: 21580-8
Protein
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: true
Publication
First Author: Wienecke R
Year: 1996
Journal: Oncogene
Title: Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.
Volume: 13
Issue: 5
Pages: 913-23
Protein Domain
Type: Family
Description: The activity of GTPases is regulated by the opposing effects of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Tuberin (tuberous sclerosis 2 protein or Tsc2) is believed to be a tumor suppressor and is able to stimulate specific GTPases. It stimulates the intrinsic GTPase activity of the Ras-related protein Rap1A and Rab5 [, ]. In complex with Tsc1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It acts as a GTPase-activating protein (GAP) for the small GTPase RheB, a direct activator of the protein kinase activity of mTORC1 [, ]. Ral GTPase-activating protein subunit alpha is the catalytic subunit of the heterodimeric RalGAP complex which acts as a GTPase activator for the Ras-like small GTPases RalA and RalB []. RalGAP complexes share structural and catalytic similarities with the tuberous sclerosis tumor suppressor complex [].
Publication  
First Author: Rifki OF
Year: 2013
Journal: J Mol Cell Cardiol
Title: RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy.
Volume: 59
Pages: 128-38
Publication
First Author: Nimnual AS
Year: 1998
Journal: Science
Title: Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
Volume: 279
Issue: 5350
Pages: 560-3
Protein
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
Protein Domain
Type: Homologous_superfamily
Description: Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP []in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP [, ]. The latter proteins are known as guanine-nucleotide exchange (or releasing) factors (GEFs or GRFs) (or also as guanine-nucleotide dissociation stimulators (GDSs)). GEFs catalyze thedissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors [, ].The crystal structure of the GEF region of human Sos1 complexes with Ras has been solved []. The structure consists of two distinct alpha helical structural domains: the N-terminal domain which seems to have a purely structural role and the C-terminal domain which is sufficient for catalytic activity and contains all residues that interact with Ras. A main feature of the catalytic domain is the protrusion of a helical hairpin important for the nucleotide-exchange mechanism. The N-terminal domain is likely to be important for the stability and correct placement of the hairpin structure.Some proteins known to contain a Ras-GEF domain are listed below:Cdc25 from yeast.Scd25 from yeast.Ste6 from fission yeast.Son of sevenless (gene sos) from Drosophila and mammals.p140-RAS GRF (cdc25Mm) from mammals. This protein possesses both a domain belonging to the CDC25 family and one belonging to the CDC24 family.Bud5 from yeast, that may interact with the ras-like protein RSR1/BUD1.Lte1 from yeast, whose target protein is not yet known.ralGDS from mammals, which interacts with the ras-like proteins ralA and ralB [].This entry represents the C-terminal catalytic domain of the Ras guanine-nucleotide exchange factors.
Protein Domain
Type: Domain
Description: Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP []in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP [, ]. The latter proteins are known as guanine-nucleotide exchange (or releasing) factors (GEFs or GRFs) (or also as guanine-nucleotide dissociation stimulators (GDSs)). GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors [, ].The crystal structure of the GEF region of human Sos1 complexes with Ras has been solved []. The structure consists of two distinct alpha helical structural domains: the N-terminal domain which seems to have a purely structural role and the C-terminal domain which is sufficient for catalytic activity and contains all residues that interact with Ras. A main feature of the catalytic domain is the protrusion of a helical hairpin important for the nucleotide-exchange mechanism. The N-terminal domain is likely to be important for the stability and correct placement of the hairpin structure.Some proteins known to contain a Ras-GEF domain are listed below:Cdc25 from yeast.Scd25 from yeast.Ste6 from fission yeast.Son of sevenless (gene sos) from Drosophila and mammals.p140-RAS GRF (cdc25Mm) from mammals. This protein possesses both a domain belonging to the CDC25 family and one belonging to the CDC24 family.Bud5 from yeast, that may interact with the ras-like protein RSR1/BUD1.Lte1 from yeast, whose target protein is not yet known.ralGDS from mammals, which interacts with the ras-like proteins ralA and ralB [].This entry represents the catalytic domain of the Ras guanine-nucleotide exchange factors.
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
Publication
First Author: Li Y
Year: 2004
Journal: Mol Cell Biol
Title: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Volume: 24
Issue: 18
Pages: 7965-75
Publication
First Author: Tee AR
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Volume: 99
Issue: 21
Pages: 13571-6
Protein
Organism: Mus musculus/domesticus
Length: 662  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
Publication
First Author: Quilliam LA
Year: 1995
Journal: Bioessays
Title: Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins.
Volume: 17
Issue: 5
Pages: 395-404
Publication
First Author: Downward J
Year: 1992
Journal: Curr Biol
Title: Ras regulation: putting back the GTP.
Volume: 2
Issue: 6
Pages: 329-31
Protein
Organism: Mus musculus/domesticus
Length: 1484  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1507  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1491  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true