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Search results 101 to 200 out of 209 for Rangap1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267923
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_23
Specimen Label: euxassay_005228_23
Detected: true
Specimen Num: 22
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•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267923
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_24
Specimen Label: euxassay_005228_24
Detected: true
Specimen Num: 23
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_02
Specimen Label: euxassay_005228_02
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_03
Specimen Label: euxassay_005228_03
Detected: true
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_04
Specimen Label: euxassay_005228_04
Detected: true
Specimen Num: 3
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_05
Specimen Label: euxassay_005228_05
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_06
Specimen Label: euxassay_005228_06
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_07
Specimen Label: euxassay_005228_07
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_08
Specimen Label: euxassay_005228_08
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_09
Specimen Label: euxassay_005228_09
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_10
Specimen Label: euxassay_005228_10
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_11
Specimen Label: euxassay_005228_11
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_12
Specimen Label: euxassay_005228_12
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_13
Specimen Label: euxassay_005228_13
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_14
Specimen Label: euxassay_005228_14
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_15
Specimen Label: euxassay_005228_15
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_16
Specimen Label: euxassay_005228_16
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_17
Specimen Label: euxassay_005228_17
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_18
Specimen Label: euxassay_005228_18
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_19
Specimen Label: euxassay_005228_19
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_20
Specimen Label: euxassay_005228_20
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_21
Specimen Label: euxassay_005228_21
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_22
Specimen Label: euxassay_005228_22
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_23
Specimen Label: euxassay_005228_23
Detected: true
Specimen Num: 22
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_24
Specimen Label: euxassay_005228_24
Detected: true
Specimen Num: 23
•
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Publication
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Journal: Mol Cell Biol
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Protein
P46061
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Fragment?: false
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Publication
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Publication
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Publication
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Publication
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Journal: Database Download
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Publication
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
9019411 | J:38226
First Author: Mahajan R
Year: 1997
Journal: Cell
Title: A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
Volume: 88
Issue: 1
Pages: 97-107
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Publication
19011093 | -
First Author: Xu XM
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: RanGAP1 is a continuous marker of the Arabidopsis cell division plane.
Volume: 105
Issue: 47
Pages: 18637-42
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Publication
9427648 | -
First Author: Saitoh H
Year: 1998
Journal: Curr Biol
Title: Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2.
Volume: 8
Issue: 2
Pages: 121-4
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Publication
9442102 | -
First Author: Mahajan R
Year: 1998
Journal: J Cell Biol
Title: Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association.
Volume: 140
Issue: 2
Pages: 259-70
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Publication
26506250 | -
First Author: Cha K
Year: 2015
Journal: PLoS One
Title: The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.
Volume: 10
Issue: 10
Pages: e0141309
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Publication
16469311 | -
First Author: Zhu S
Year: 2006
Journal: Exp Cell Res
Title: SUMO modification through rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes.
Volume: 312
Issue: 7
Pages: 1042-9
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Protein Domain
IPR009109 | Ran_GTPase_activating_1_C
Type: Domain
Description: Ran GTPase is a ubiquitous protein required for nuclear transport, spindle assembly, nuclear assembly and mitotic cell cycle regulation. RanGTPase activating protein 1 (RanGAP1) is one of several RanGTPase accessory proteins. During interphase, RanGAP1 is located in the cytoplasm, while during mitosis it becomes associated with the kinetochores []. Cytoplasmic RanGAP1 is required for RanGTPase-directed nuclear transport. The activity of RanGAP1 requires the accessory protein RanBP1. RanBP1 facilitates RanGAP1 hydrolysis of Ran-GTP, both directly and by promoting the dissociation of Ran-GTP from transport receptors, which would otherwise block RanGAP1-mediated hydrolysis. RanGAP1 is thought to bind to the Switch 1 and Switch 2 regions of RanGTPase. The Switch 2 region can be buried in complexes with karyopherin-beta2, and requires the interaction with RanBP1 to permit RanGAP1 function. RanGAP1 can undergo SUMO (small ubiquitin-like modifier) modification, which targets RanGAP1 to RanBP2/Nup358 in the nuclear pore complex, and is required for association with the nuclear pore complex and for nuclear transport []. The enzymes involved in SUMO modification are located on the filaments of the nuclear pore complex.The RanGAP1 N-terminal domain is fairly well conserved between vertebrate and fungal proteins, but yeast does not contain the C-terminal domain. The C-terminal domain is SUMO-modified and required for the localisation of RanGAP1 at the nuclear pore complex. The structure of the C-terminal domain is multihelical, consisting of two curved alpha/alpha layers in a right-handed superhelix.
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Protein Domain
IPR036720 | RanGAP1_C_sf
Type: Homologous_superfamily
Description: Ran GTPase is a ubiquitous protein required for nuclear transport, spindle assembly, nuclear assembly and mitotic cell cycle regulation. RanGTPase activating protein 1 (RanGAP1) is one of several RanGTPase accessory proteins. During interphase, RanGAP1 is located in the cytoplasm, while during mitosis it becomes associated with the kinetochores []. Cytoplasmic RanGAP1 is required for RanGTPase-directed nuclear transport. The activity of RanGAP1 requires the accessory protein RanBP1. RanBP1 facilitates RanGAP1 hydrolysis of Ran-GTP, both directly and by promoting the dissociation of Ran-GTP from transport receptors, which would otherwise block RanGAP1-mediated hydrolysis. RanGAP1 is thought to bind to the Switch 1 and Switch 2 regions of RanGTPase. The Switch 2 region can be buried in complexes with karyopherin-beta2, and requires the interaction with RanBP1 to permit RanGAP1 function. RanGAP1 can undergo SUMO (small ubiquitin-like modifier) modification, which targets RanGAP1 to RanBP2/Nup358 in the nuclear pore complex, and is required for association with the nuclear pore complex and for nuclear transport []. The enzymes involved in SUMO modification are located on the filaments of the nuclear pore complex.The RanGAP1 N-terminal domain is fairly well conserved between vertebrate and fungal proteins, but yeast does not contain the C-terminal domain. The C-terminal domain is SUMO-modified and required for the localisation of RanGAP1 at the nuclear pore complex. The structure of the C-terminal domain is multihelical, consisting of two curved alpha/alpha layers in a right-handed superhelix.
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Publication
11853669 | -
First Author: Bernier-Villamor V
Year: 2002
Journal: Cell
Title: Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.
Volume: 108
Issue: 3
Pages: 345-56
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Protein
Q9CW20
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
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Publication
12852855 | -
First Author: Arnaoutov A
Year: 2003
Journal: Dev Cell
Title: The Ran GTPase regulates kinetochore function.
Volume: 5
Issue: 1
Pages: 99-111
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Publication
12061901 | -
First Author: Pay A
Year: 2002
Journal: Plant J
Title: Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells.
Volume: 30
Issue: 6
Pages: 699-709
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Protein Domain
IPR045203 | RanGAP1/2
Type: Family
Description: This entry includes RanGAP1/2 mostly from plants. They are GTPase activators for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state []. RanGAP1 may have a role in spatial signaling during plant cell division [].
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Protein
A0A2R8W753
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
Q3UZD8
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
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Protein
Q3ULJ9
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q6ZPH4
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: true
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Protein
Q8C2E3
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein Domain
IPR022011 | IR1-M
Type: Domain
Description: This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with , , . There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.
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Protein
A0A2R8VHK9
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
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Publication
38177100 | J:355741
First Author: Liu ML
Year: 2024
Journal: Cell Death Dis
Title: Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease.
Volume: 15
Issue: 1
Pages: 4
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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