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Search results 101 to 196 out of 196 for Rap1b

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Type Details Score
Publication
18577515 | J:140367
First Author: Sabbatini ME
Year: 2008
Journal: J Biol Chem
Title: Rap1 activation plays a regulatory role in pancreatic amylase secretion.
Volume: 283
Issue: 35
Pages: 23884-94
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Publication
18422604 | J:141709
First Author: Takahashi M
Year: 2008
Journal: Genes Cells
Title: Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells.
Volume: 13
Issue: 6
Pages: 549-69
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Publication
26921307 | J:256602
First Author: Ueda Y
Year: 2016
Journal: J Immunol
Title: Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition.
Volume: 196
Issue: 7
Pages: 3019-31
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Publication
37545505 | J:347281
 
First Author: Horitani S
Year: 2023
Journal: Front Immunol
Title: The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes.
Volume: 14
Pages: 1234747
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Publication
11056535 | J:71886
First Author: Ozaki N
Year: 2000
Journal: Nat Cell Biol
Title: cAMP-GEFII is a direct target of cAMP in regulated exocytosis.
Volume: 2
Issue: 11
Pages: 805-11
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Publication
36001955 | J:344141
First Author: Wang Y
Year: 2022
Journal: Cell Rep
Title: Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia.
Volume: 40
Issue: 8
Pages: 111259
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Publication
25705885 | J:221899
First Author: Stefanini L
Year: 2015
Journal: J Clin Invest
Title: RASA3 is a critical inhibitor of RAP1-dependent platelet activation.
Volume: 125
Issue: 4
Pages: 1419-32
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Publication
33104169 | J:310835
 
First Author: Sun H
Year: 2021
Journal: J Exp Med
Title: Distinct integrin activation pathways for effector and regulatory T cell trafficking and function.
Volume: 218
Issue: 2
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Publication
23230271 | J:194413
First Author: Zou W
Year: 2013
Journal: Mol Cell Biol
Title: Talin1 and Rap1 are critical for osteoclast function.
Volume: 33
Issue: 4
Pages: 830-44
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Publication
28137909 | J:244369
 
First Author: Kondo N
Year: 2017
Journal: Mol Cell Biol
Title: NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization.
Volume: 37
Issue: 8
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Publication
35197328 | J:322712
First Author: Lagarrigue F
Year: 2022
Journal: J Immunol
Title: Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4+ T Cells.
Volume: 208
Issue: 6
Pages: 1378-1388
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Publication
29320740 | J:271262
First Author: Zhao XF
Year: 2018
Journal: Cell Rep
Title: PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors.
Volume: 22
Issue: 2
Pages: 456-470
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Publication
37276970 | J:337132
 
First Author: Hiremath C
Year: 2023
Journal: Dev Biol
Title: Rap1 regulates lumen continuity via Afadin in renal epithelia.
Volume: 501
Pages: 20-27
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Publication
37598341 | J:341186
First Author: Sun H
Year: 2023
Journal: Cell Rep
Title: IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function.
Volume: 42
Issue: 8
Pages: 112996
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Publication
25721469 | J:242457
First Author: Qiao S
Year: 2015
Journal: Dev Neurosci
Title: Dab2IP Regulates Neuronal Positioning, Rap1 Activity and Integrin Signaling in the Developing Cortex.
Volume: 37
Issue: 2
Pages: 131-41
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Publication
36782228 | J:333325
First Author: Cheng Q
Year: 2023
Journal: Mol Brain
Title: Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation.
Volume: 16
Issue: 1
Pages: 24
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Publication
37267105 | J:338516
First Author: Kamioka Y
Year: 2023
Journal: Cell Rep
Title: Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
Volume: 42
Issue: 6
Pages: 112580
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Publication
1555775 | J:24144
First Author: Chavrier P
Year: 1992
Journal: Gene
Title: The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.
Volume: 112
Issue: 2
Pages: 261-4
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Publication
10926822 | J:172908
 
First Author: Traver S
Year: 2000
Journal: Biochem J
Title: RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.
Volume: 350 Pt 1
Pages: 19-29
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Publication
30592646 | J:288966
First Author: Chang S
Year: 2019
Journal: FASEB J
Title: The effect of folic acid deficiency on FGF pathway via Brachyury regulation in neural tube defects.
Volume: 33
Issue: 4
Pages: 4688-4702
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Publication
27626668 | J:238993
First Author: Kaneko K
Year: 2016
Journal: Cell Rep
Title: Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions.
Volume: 16
Issue: 11
Pages: 3003-3015
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Publication
21945075 | J:178484
First Author: Maddala R
Year: 2011
Journal: Dev Biol
Title: Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.
Volume: 360
Issue: 1
Pages: 30-43
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Publication
14712229 | J:88364
First Author: Weissman JT
Year: 2004
Journal: Oncogene
Title: G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway.
Volume: 23
Issue: 1
Pages: 241-9
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Publication
23209302 | J:195239
First Author: Ahmed SM
Year: 2012
Journal: J Cell Biol
Title: KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Volume: 199
Issue: 6
Pages: 951-67
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Publication
35998584 | J:327957
First Author: Kim YS
Year: 2022
Journal: Dev Cell
Title: Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition.
Volume: 57
Issue: 16
Pages: 1937-1956.e8
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Publication
26733533 | J:241040
First Author: Shah B
Year: 2017
Journal: Cereb Cortex
Title: Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex.
Volume: 27
Issue: 2
Pages: 1253-1269
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Publication
29360039 | J:273460
   
First Author: Collins TN
Year: 2018
Journal: Elife
Title: Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Volume: 7
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
11970953 | J:77671
First Author: Woulfe D
Year: 2002
Journal: J Biol Chem
Title: Activation of Rap1B by G(i) family members in platelets.
Volume: 277
Issue: 26
Pages: 23382-90
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Publication
29170462 | J:256314
First Author: Zhu L
Year: 2017
Journal: Nat Commun
Title: Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation.
Volume: 8
Issue: 1
Pages: 1744
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Publication
18625726 | J:140236
First Author: Yan J
Year: 2008
Journal: Mol Cell Biol
Title: Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.
Volume: 28
Issue: 18
Pages: 5803-10
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Publication
15286792 | -
First Author: Schwamborn JC
Year: 2004
Journal: Nat Neurosci
Title: The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.
Volume: 7
Issue: 9
Pages: 923-9
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Publication
21940635 | -
First Author: Zhang G
Year: 2011
Journal: J Biol Chem
Title: Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling.
Volume: 286
Issue: 45
Pages: 39466-77
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Publication
13679863 | -
First Author: Mitra RS
Year: 2003
Journal: Oncogene
Title: Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.
Volume: 22
Issue: 40
Pages: 6243-56
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Publication
24165023 | -
First Author: Nakamura T
Year: 2013
Journal: Genes Cells
Title: Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.
Volume: 18
Issue: 11
Pages: 1020-31
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Allele
Igs79<em1Aven> | MGI:7620007
 
Name: intergenic site 79; endonuclease-mediated mutation 1, Andrea Ventura
Allele Type: Endonuclease-mediated
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Allele
Igs80<em1Aven> | MGI:7620008
 
Name: intergenic site 80; endonuclease-mediated mutation 1, Andrea Ventura
Allele Type: Endonuclease-mediated
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Publication
9611133 | -
First Author: D'Silva NJ
Year: 1998
Journal: Am J Physiol
Title: Beta-adrenergic-induced cytosolic redistribution of Rap1 in rat parotid acini: role in secretion.
Volume: 274
Issue: 6 Pt 1
Pages: C1667-73
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Publication
11836528 | J:74992
First Author: Sebzda E
Year: 2002
Journal: Nat Immunol
Title: Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling.
Volume: 3
Issue: 3
Pages: 251-8
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Protein Domain
IPR038851 | Rap1
Type: Family
Description: The Rap1 subgroup is part of the Rap subfamily of the Ras family. It can be further divided into the Rap1a and Rap1b isoforms. In humans, Rap1a and Rap1b share 95% sequence homology, but are products of two different genes located on chromosomes 1 and 12, respectively. Rap1a is sometimes called smg p21 or Krev1 in the older literature.Rap1 proteins are believed to perform different cellular functions, depending on the isoform, its subcellular localization, and the effector proteins it binds. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules [, ]. High expression of Rap1 has been observed in the nucleus of human oropharyngeal squamous cell carcinomas (SCCs) and cell lines; interestingly, in the SCCs, the active GTP-bound form localized to the nucleus, while the inactive GDP-bound form localized to the cytoplasm []. Rap1a, which is stimulated by T-cell receptor (TCR) activation, is a positive regulator of T cells by directing integrin activation and augmenting lymphocyte responses []. In murine hippocampal neurons, Rap1b determines which neurite will become the axon and directs the recruitment ofCdc42, which is required for formation of dendrites and axons []. In murine platelets, Rap1b is required for normal homeostasis in vivo and is involved in integrin activation [].
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Strain
MGI:7620055 | B6(129S4)-Igs79<em1Aven> Igs80<em1Aven>/J
Attribute String: endonuclease-mediated mutation, mutant strain
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Publication
- | J:346905
     
First Author: Pradella D
Year: 2023
Journal: bioRxiv
Title: Immortalization and transformation of primary cells mediated by engineered ecDNAs.
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Publication
18660803 | J:155189
First Author: Rehmann H
Year: 2008
Journal: Nature
Title: Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.
Volume: 455
Issue: 7209
Pages: 124-7
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Publication
19515725 | J:152267
First Author: Canobbio I
Year: 2009
Journal: Blood
Title: Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.
Volume: 114
Issue: 10
Pages: 2193-6
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Publication
32795414 | J:360185
First Author: Hoshino A
Year: 2020
Journal: Cell
Title: Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.
Volume: 182
Issue: 4
Pages: 1044-1061.e18
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Publication
36532012 | J:337560
 
First Author: Zhai S
Year: 2022
Journal: Front Immunol
Title: H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation.
Volume: 13
Pages: 959021
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Publication
16382154 | J:144145
First Author: Duchniewicz M
Year: 2006
Journal: Mol Cell Biol
Title: Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion.
Volume: 26
Issue: 2
Pages: 643-53
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Publication
38342927 | J:360437
First Author: Zhang W
Year: 2024
Journal: Nat Commun
Title: Sonic hedgehog-heat shock protein 90β axis promotes the development of nonalcoholic steatohepatitis in mice.
Volume: 15
Issue: 1
Pages: 1280
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Publication
17673465 | J:125348
First Author: Schoenwaelder SM
Year: 2007
Journal: J Biol Chem
Title: Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.
Volume: 282
Issue: 39
Pages: 28648-58
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Publication
27111087 | J:248896
First Author: Shah B
Year: 2016
Journal: PLoS One
Title: C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development.
Volume: 11
Issue: 4
Pages: e0154174
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Publication
23236426 | J:195679
First Author: Xiang B
Year: 2012
Journal: PLoS One
Title: The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.
Volume: 7
Issue: 12
Pages: e51037
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Publication
22106345 | J:181791
First Author: Consonni A
Year: 2012
Journal: Blood
Title: Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.
Volume: 119
Issue: 3
Pages: 847-56
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Publication
30242097 | J:322715
First Author: Lagarrigue F
Year: 2018
Journal: Blood Adv
Title: Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.
Volume: 2
Issue: 18
Pages: 2358-2368
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Publication
26859226 | J:248779
First Author: Zou F
Year: 2016
Journal: FEBS J
Title: Targeted deletion of miR-139-5p activates MAPK, NF-κB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer.
Volume: 283
Issue: 8
Pages: 1438-52
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Publication
26269639 | J:226021
First Author: Muñoz-Llancao P
Year: 2015
Journal: J Neurosci
Title: Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
Volume: 35
Issue: 32
Pages: 11315-29
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Publication
23633676 | J:259370
First Author: Idevall-Hagren O
Year: 2013
Journal: Sci Signal
Title: Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.
Volume: 6
Issue: 273
Pages: ra29.1-11, S1-6
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Protein
P62835
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q99JI6
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q3V3W9
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
A0A0G2JE52
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
C5H0E8
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q3U7U8
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
C5H0E9
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q52L50
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
29802205 | J:287791
First Author: Sauter RJ
Year: 2018
Journal: Circulation
Title: Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
Volume: 138
Issue: 16
Pages: 1720-1735
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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