Type |
Details |
Score |
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Allele |
Name: |
Ras association (RalGDS/AF-6) domain family member 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Interaction Experiment |
Description: |
Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5. |
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•
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Publication |
First Author: |
Liu L |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5. |
Volume: |
65 |
Issue: |
5 |
Pages: |
1830-8 |
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•
•
•
•
•
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Publication |
First Author: |
Hwang E |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. |
Volume: |
104 |
Issue: |
22 |
Pages: |
9236-41 |
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Protein Domain |
Type: |
Domain |
Description: |
The SARAH (Sav/Rassf/Hpo) domain is found at the C terminus in three classes of eukaryotic tumour suppressors that give the domain its name. In the Sav (Salvador) and Hpo (Hippo) families, the SARAH domain mediates signal transduction from Hpo via the Sav scaffolding protein to the downstream component Wts (Warts); the phosphorylation of Wts by Hpo triggers cell cycle arrest and apoptosis by down-regulating cyclin E, Diap 1 and other targets [, ]. The SARAH domain is also involved in dimerisation, as in the human Hpo orthologue, Mst1, which homodimerises via its C-terminal SARAH domain. The SARAH domain is found associated with other domains, such as protein kinase domains, WW/rsp5/WWP domain (), C1 domain (), LIM domain (), or the Ras-associating (RA) domain ().This entry represents the C-terminal SARAH domain of Mst1. The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process []. |
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Publication |
First Author: |
Khokhlatchev A |
Year: |
2002 |
Journal: |
Curr Biol |
Title: |
Identification of a novel Ras-regulated proapoptotic pathway. |
Volume: |
12 |
Issue: |
4 |
Pages: |
253-65 |
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•
•
•
•
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Publication |
First Author: |
Ortiz-Vega S |
Year: |
2002 |
Journal: |
Oncogene |
Title: |
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |
Volume: |
21 |
Issue: |
9 |
Pages: |
1381-90 |
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•
•
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•
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Publication |
First Author: |
Park J |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. |
Volume: |
285 |
Issue: |
45 |
Pages: |
35029-38 |
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•
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Publication |
First Author: |
Dubois F |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway. |
Volume: |
76 |
Issue: |
6 |
Pages: |
1627-40 |
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Publication |
First Author: |
MartÃnez-Chantar ML |
Year: |
2008 |
Journal: |
Hepatology |
Title: |
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. |
Volume: |
47 |
Issue: |
4 |
Pages: |
1191-9 |
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•
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Publication |
First Author: |
Scheel H |
Year: |
2003 |
Journal: |
Curr Biol |
Title: |
A novel interaction motif, SARAH, connects three classes of tumor suppressor. |
Volume: |
13 |
Issue: |
23 |
Pages: |
R899-900 |
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•
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|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
126
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Cairns L |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
Salvador has an extended SARAH domain that mediates binding to Hippo kinase. |
Volume: |
293 |
Issue: |
15 |
Pages: |
5532-5543 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
321
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
497
 |
Fragment?: |
false |
|
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
487
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
495
 |
Fragment?: |
false |
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•
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