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Search results 101 to 108 out of 108 for Rassf5

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Type

Details

Score

Protein Domain

IPR024205 | Mst1_SARAH_domain

Type:

Domain

Description:

The SARAH (Sav/Rassf/Hpo) domain is found at the C terminus in three classes of eukaryotic tumour suppressors that give the domain its name. In the Sav (Salvador) and Hpo (Hippo) families, the SARAH domain mediates signal transduction from Hpo via the Sav scaffolding protein to the downstream component Wts (Warts); the phosphorylation of Wts by Hpo triggers cell cycle arrest and apoptosis by down-regulating cyclin E, Diap 1 and other targets [, ]. The SARAH domain is also involved in dimerisation, as in the human Hpo orthologue, Mst1, which homodimerises via its C-terminal SARAH domain. The SARAH domain is found associated with other domains, such as protein kinase domains, WW/rsp5/WWP domain (), C1 domain (), LIM domain (), or the Ras-associating (RA) domain ().This entry represents the C-terminal SARAH domain of Mst1. The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process [].

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Publication

14654011 | -

First Author:	Scheel H
Year:	2003
Journal:	Curr Biol
Title:	A novel interaction motif, SARAH, connects three classes of tumor suppressor.
Volume:	13
Issue:	23
Pages:	R899-900

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Protein

Q8CDG4

Organism:	Mus musculus/domesticus
Length:	126
Fragment?:	false

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Publication

29519817 | -

First Author:	Cairns L
Year:	2018
Journal:	J Biol Chem
Title:	Salvador has an extended SARAH domain that mediates binding to Hippo kinase.
Volume:	293
Issue:	15
Pages:	5532-5543

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Protein

Q9CW82

Organism:	Mus musculus/domesticus
Length:	321
Fragment?:	true

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Protein

Q9JI10

Organism:	Mus musculus/domesticus
Length:	497
Fragment?:	false

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Protein

Q9JI11

Organism:	Mus musculus/domesticus
Length:	487
Fragment?:	false

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Protein

A0A2I3BQE0

Organism:	Mus musculus/domesticus
Length:	495
Fragment?:	false

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