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Search results 101 to 200 out of 208 for Rbx1

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Type Details Score
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase RBX1
Type: chain
End: 108
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Publication
11384984 | -
First Author: Kamura T
Year: 2001
Journal: J Biol Chem
Title: Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
Volume: 276
Issue: 32
Pages: 29748-53
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Publication
10643962 | -
First Author: Périn J-P
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1.
Volume: 45
Issue: 8
Pages: 1131-7
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Protein
A0A2R8W6R3
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: false
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Protein
A0A2R8W6G1
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: false
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Interaction Experiment
Kamura T (2001)
Description: Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
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Publication
14622138 | -
First Author: Sasagawa Y
Year: 2003
Journal: Genes Cells
Title: Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis.
Volume: 8
Issue: 11
Pages: 857-72
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Publication
15772280 | -
First Author: Figueroa P
Year: 2005
Journal: Plant Cell
Title: Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo.
Volume: 17
Issue: 4
Pages: 1180-95
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Publication
12149480 | -
First Author: Brower CS
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Volume: 99
Issue: 16
Pages: 10353-8
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Allele
Cul4a<tm1.2Pz> | MGI:3851025
Name: cullin 4A; targeted mutation 1.2, Pengbo Zhou
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:3851177 | B6.Cg-Cul4a<tm1.2Pz>
Attribute String: congenic, targeted mutation
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Genotype
Genotype
Symbol: Cul4a/Cul4a
Background: B6.Cg-Cul4a
Zygosity: hm
Has Mutant Allele: true
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Publication
31817461 | -
 
First Author: Wan X
Year: 2019
Journal: Plants (Basel)
Title: AtSIBP1, a Novel BTB Domain-Containing Protein, Positively Regulates Salt Signaling in Arabidopsis thaliana.
Volume: 8
Issue: 12
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Protein Domain
IPR044714 | AtSIBP1-like
Type: Family
Description: This entry includes a group of BTB/POZ domain-containing protein, including At1g55760 (AtSIBP1) and At1g21780 from Arabidopsis. AtSIBP1 is induced by salt and other stresses and can positively regulate salt signalling []. The function of At1g21780 is not clear. Its BTB domain has been shown to interact with itself and with AtCUL3A. It might form an E3 ubiquitin ligase complex with RBX1 and AtCUL3A [].
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Pseudogene
MGI:3710517 | Rbx1-ps
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_129S1SvImJ_G0011345 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_AJ_G0011333 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_AKRJ_G0011297 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_BALBcJ_G0011310 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_C3HHeJ_G0011198 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGI_C57BL6J_3710517 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_C57BL6NJ_G0011601 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_CASTEiJ_G0011016 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_CBAJ_G0011178 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_DBA2J_G0011231 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_FVBNJ_G0011231 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_LPJ_G0011312 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_NODShiLtJ_G0011226 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_NZOHlLtJ_G0011578 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_PWKPhJ_G0010888 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_WSBEiJ_G0011058 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_SPRETEiJ_G0010713 | -
Type: pseudogene
Organism: Mus spretus
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Publication
11735228 | J:73276
First Author: Maruyama S
Year: 2001
Journal: Genomics
Title: Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.
Volume: 78
Issue: 3
Pages: 214-22
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Publication
11961546 | J:76096
First Author: Zheng N
Year: 2002
Journal: Nature
Title: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Volume: 416
Issue: 6882
Pages: 703-9
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Publication
31237565 | J:290970
   
First Author: Jung M
Year: 2019
Journal: Elife
Title: Unified single-cell analysis of testis gene regulation and pathology in five mouse strains.
Volume: 8
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Publication
10531037 | J:58149
First Author: Winston JT
Year: 1999
Journal: Curr Biol
Title: A family of mammalian F-box proteins.
Volume: 9
Issue: 20
Pages: 1180-2
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Publication
17332328 | J:118603
First Author: Skaar JR
Year: 2007
Journal: Cancer Res
Title: PARC and CUL7 form atypical cullin RING ligase complexes.
Volume: 67
Issue: 5
Pages: 2006-14
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Publication
24430184 | J:207982
First Author: Li H
Year: 2014
Journal: J Clin Invest
Title: Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.
Volume: 124
Issue: 2
Pages: 835-46
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Publication
21205095 | J:297018
First Author: Matsumoto A
Year: 2011
Journal: Cancer Sci
Title: Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.
Volume: 102
Issue: 4
Pages: 749-55
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Publication
10531039 | J:58150
First Author: Wang Y
Year: 1999
Journal: Curr Biol
Title: Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E.
Volume: 9
Issue: 20
Pages: 1191-4
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Publication
26286618 | J:229424
First Author: Schumacher FR
Year: 2015
Journal: EMBO Mol Med
Title: Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.
Volume: 7
Issue: 10
Pages: 1285-306
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Publication
23454126 | J:201235
First Author: Baird L
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
Volume: 433
Issue: 1
Pages: 58-65
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Publication
26100637 | J:224601
First Author: Ibeawuchi SR
Year: 2015
Journal: J Biol Chem
Title: Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.
Volume: 290
Issue: 31
Pages: 19208-17
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Publication
29070679 | J:253425
First Author: Chen F
Year: 2017
Journal: J Biol Chem
Title: The E3 ubiquitin ligase SCFFBXL14 complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis.
Volume: 292
Issue: 49
Pages: 20100-20112
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Publication
35687106 | J:326771
     
First Author: Lao L
Year: 2022
Journal: Nucleic Acids Res
Title: ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.
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Publication
17062563 | J:117680
First Author: Salinas GD
Year: 2006
Journal: J Biol Chem
Title: Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway.
Volume: 281
Issue: 52
Pages: 40164-73
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Publication
31279627 | -
First Author: Chen Z
Year: 2019
Journal: Structure
Title: Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
Volume: 27
Issue: 9
Pages: 1395-1404.e4
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Publication
17337451 | -
First Author: da Silva Correia J
Year: 2007
Journal: J Biol Chem
Title: The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis.
Volume: 282
Issue: 17
Pages: 12557-65
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Publication
18060501 | -
First Author: Hetfeld BK
Year: 2008
Journal: Apoptosis
Title: The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis.
Volume: 13
Issue: 2
Pages: 187-95
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Publication
22575649 | J:184509
First Author: Zhang H
Year: 2012
Journal: FEBS Lett
Title: The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6.
Volume: 586
Issue: 8
Pages: 1147-53
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Protein Domain
IPR030594 | KLHL17/KLHL20
Type: Family
Description: Kelch-like protein 17 (KLHL17, also known as actinfilin) and Kelch-like protein 20 (KLHL20, also known as KLEIP) belong to the KLHL family []. KLHL17 binds to the actin cytoskeleton and serves as a substrate-specific adapter in the Cul3-dependent ubiquitin ligase complex that targets GluR6 kainate receptor subunit for degradation []. Kainate receptors (KAR) are ionotropic receptors that respond to the neurotransmitter glutamate and have been implicated in epilepsy, stroke, Alzheimer's and neuropathic pain [].KLHL20 assembles with CUL3 and RBX1 to form a multi-subunit Cullin-RING E3 ligase []. The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ].
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Protein Domain
IPR033859 | MPN_CSN6
Type: Family
Description: The COP9 signalosome (CSN) is a conserved protein complex that regulates the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes [], which leads to a decrease in Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 []. Protein kinases CK2 and D, which phosphorylate proteins such as cJun and p53 resulting in their degradation by the ubiquitin-26S proteasome system, also binds to CSN [, ]. The mammalian CSN typically consistis of eight subunits designated CSN1-CSN8. The fission yeast possesses a smaller version of the CSN, consisting only of six subunits, whereas a more distant CSN-like complex has been described in Saccharomyces cerevisiae [].CSN6 (COP9 signalosome subunit 6; COP9 subunit 6; MOV34 homolog, 34 kD; MEROPS identifier M67.972) is one of the eight subunits of COP9 signalosome. CSN6 is an MPN-domain protein that directly interacts with the MPN+-domain subunit CSN5 []. It is cleaved during apoptosis by activated caspases. CSN6 processing occurs in CSN/CRL (cullin-RING Ub ligase) complexes and is followed by the cleavage of Rbx1, the direct interaction partner of CSN6 []. CSN6 cleavage enhances CSN-mediated deneddylating activity (i.e. cleavage of ubiquitin-like protein Nedd8 (neural precursor cell expressed, developmentally downregulated 8)) in the cullin 1 in cells []. The cleavage of Rbx1 and increased deneddylation of cullins inactivate CRLs and presumably stabilize pro-apoptotic factors for final apoptotic steps. While CSN6 shows a typical MPN metalloprotease fold, it lacks the canonical JAMM motif, and therefore does not show catalytic isopeptidase activity.
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Publication
22448038 | J:197808
First Author: Kaspar JW
Year: 2012
Journal: J Cell Sci
Title: Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
Volume: 125
Issue: Pt 4
Pages: 1027-38
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Publication
19481525 | J:150427
First Author: Liu L
Year: 2009
Journal: Mol Cell
Title: CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.
Volume: 34
Issue: 4
Pages: 451-60
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Publication
21713671 | -
 
First Author: Marshall J
Year: 2011
Journal: Adv Exp Med Biol
Title: BTB-Kelch proteins and ubiquitination of kainate receptors.
Volume: 717
Pages: 115-25
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Protein
A0A804C8S8
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
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Protein
O88545
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
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Protein
D3Z0F5
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein
Q3UIT2
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
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Protein
Q6PDF5
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: false
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Protein
A0A804C8S9
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
Q6TDP3
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Protein
Q8VCK5
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
Q3TCA1
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Protein
B2RTE7
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Publication
11337588 | -
First Author: Lyapina S
Year: 2001
Journal: Science
Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.
Volume: 292
Issue: 5520
Pages: 1382-5
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Publication
12732143 | -
First Author: Groisman R
Year: 2003
Journal: Cell
Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
Volume: 113
Issue: 3
Pages: 357-67
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Publication
12628923 | -
First Author: Uhle S
Year: 2003
Journal: EMBO J
Title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.
Volume: 22
Issue: 6
Pages: 1302-12
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Publication
11285227 | -
First Author: Bech-Otschir D
Year: 2001
Journal: EMBO J
Title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
Volume: 20
Issue: 7
Pages: 1630-9
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Publication
18926707 | -
First Author: Wei N
Year: 2008
Journal: Trends Biochem Sci
Title: The COP9 signalosome: more than a protease.
Volume: 33
Issue: 12
Pages: 592-600
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