Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3506369 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539384 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5692 |
|
Specimen Label: |
GUDMAP:5692 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506369 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539384 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5692 |
|
Specimen Label: |
GUDMAP:5692 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawase S |
Year: |
2014 |
Journal: |
Stem Cells Dev |
Title: |
Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells. |
Volume: |
23 |
Issue: |
18 |
Pages: |
2250-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dubruille R |
Year: |
2002 |
Journal: |
Development |
Title: |
Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation. |
Volume: |
129 |
Issue: |
23 |
Pages: |
5487-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lemeille S |
Year: |
2020 |
Journal: |
Nucleic Acids Res |
Title: |
Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis. |
Volume: |
48 |
Issue: |
16 |
Pages: |
9019-9036 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elkon R |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
RFX transcription factors are essential for hearing in mice. |
Volume: |
6 |
|
Pages: |
8549 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bae BI |
Year: |
2014 |
Journal: |
Science |
Title: |
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. |
Volume: |
343 |
Issue: |
6172 |
Pages: |
764-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carver EA |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1039-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2020 |
Journal: |
Nucleic Acids Res |
Title: |
Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium. |
Volume: |
48 |
Issue: |
6 |
Pages: |
2880-2896 |
|
•
•
•
•
•
|
Publication |
First Author: |
Doyle J |
Year: |
1997 |
Journal: |
Mamm Genome |
Title: |
Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice. |
Volume: |
8 |
Issue: |
2 |
Pages: |
113-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herranz-Pérez V |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice. |
Volume: |
12 |
Issue: |
1 |
Pages: |
1493 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ashique AM |
Year: |
2009 |
Journal: |
Sci Signal |
Title: |
The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. |
Volume: |
2 |
Issue: |
95 |
Pages: |
ra70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimada IS |
Year: |
2019 |
Journal: |
Dev Biol |
Title: |
Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities. |
Volume: |
450 |
Issue: |
1 |
Pages: |
47-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blackshaw S |
Year: |
2004 |
Journal: |
PLoS Biol |
Title: |
Genomic analysis of mouse retinal development. |
Volume: |
2 |
Issue: |
9 |
Pages: |
E247 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
910
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
71
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Katan Y |
Year: |
1997 |
Journal: |
Nucleic Acids Res |
Title: |
The transcriptional activation and repression domains of RFX1, a context-dependent regulator, can mutually neutralize their activities. |
Volume: |
25 |
Issue: |
18 |
Pages: |
3621-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The RFX family is a family of winged-helix DNA-binding proteins. RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is found N-terminal to the RFX DNA-binding region () in some mammalian RFX proteins, and is thought to activate transcription when associated with DNA. Deletion analysis has identified the region 233-351 in human RFX1 () as being required for maximal activation []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu M |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Involvement of RFX1 protein in the regulation of the human proliferating cell nuclear antigen promoter. |
Volume: |
274 |
Issue: |
22 |
Pages: |
15433-9 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
MHC class II regulatory factor RFX1 |
Type: |
chain |
End: |
963 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katan-Khaykovich Y |
Year: |
1999 |
Journal: |
J Mol Biol |
Title: |
The dimerization/repression domain of RFX1 is related to a conserved region of its yeast homologues Crt1 and Sak1: a new function for an ancient motif. |
Volume: |
294 |
Issue: |
1 |
Pages: |
121-37 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
717
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
749
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
695
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
458
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
724
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
226
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
963
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Horvath GC |
Year: |
2004 |
Journal: |
Biol Reprod |
Title: |
RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis. |
Volume: |
71 |
Issue: |
5 |
Pages: |
1551-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
245
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
270
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
364
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
481
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Aftab S |
Year: |
2008 |
Journal: |
BMC Evol Biol |
Title: |
Identification and characterization of novel human tissue-specific RFX transcription factors. |
Volume: |
8 |
|
Pages: |
226 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chandra V |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells. |
Volume: |
9 |
Issue: |
6 |
Pages: |
2206-18 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes Rfx1 from budding yeasts, Sak1 from fission yeasts and RFX1-8 from humans []. They are transcription factors that contain a RFX DNA binding domain and a conserved C-terminal region [].Mutations in the RFX5 gene cause Bare lymphocyte syndrome 2 (BLS2), a severe combined immunodeficiency disease with early onset []. Mutations in the RFX6 gene cause Mitchell-Riley syndrome (MTCHRS), a disorder characterized by neonatal diabetes, hypoplastic or annular pancreas, duodenal and jejunal atresia, and absent gallbladder [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Coffin SL |
Year: |
2022 |
Journal: |
Neuron |
Title: |
Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bonnafe E |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. |
Volume: |
24 |
Issue: |
10 |
Pages: |
4417-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Durand B |
Year: |
2000 |
Journal: |
Gene |
Title: |
Cloning and characterization of dRFX, the Drosophila member of the RFX family of transcription factors. |
Volume: |
246 |
Issue: |
1-2 |
Pages: |
285-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakayama A |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. |
Volume: |
278 |
Issue: |
1 |
Pages: |
233-40 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
90
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
105
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
95
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Nekrep N |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex. |
Volume: |
20 |
Issue: |
12 |
Pages: |
4455-61 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
735
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
927
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
596
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
614
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
131
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
893
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1459
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
291
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
658
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
570
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|