Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775122 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274122 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1624622 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the digestive system. |
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1721422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1646922 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1736222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1683322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1700022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1832122 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the immune system. |
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280922 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1833322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1821522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3557722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702122 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1802422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1768022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the skull (base and vault). |
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310096 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423420 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in whisker follicle. |
Specimen Label: |
EN491; Specimen N308 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strausberg R |
Year: |
2002 |
Journal: |
GenBank Submission |
Title: |
Mus musculus, regulatory factor x-associated protein, clone MGC: 32426 IMAGE: 5041039, mRNA, complete cds |
|
|
Pages: |
BC019935 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue S |
Year: |
2000 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. |
Volume: |
268 |
Issue: |
2 |
Pages: |
553-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hester M |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Smad1 and Smad8 function similarly in mammalian central nervous system development. |
Volume: |
25 |
Issue: |
11 |
Pages: |
4683-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Laird KM |
Year: |
2010 |
Journal: |
J Mol Biol |
Title: |
Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex. |
Volume: |
403 |
Issue: |
1 |
Pages: |
40-51 |
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Allele |
Name: |
class II transactivator; targeted mutation 2, Walter Reith |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Allele |
Name: |
class II transactivator; targeted mutation 1, Cheong-Hee Chang |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Genotype |
Symbol: |
Ciita/Ciita |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Ciita/Ciita |
Background: |
involves: 129S2/SvPas * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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DO Term |
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This superfamily represents the C-terminal domain ofRFXAP (regulatory factor X-associated protein) that binds to RFXANK [, ], the ankyrin-repeat regulatory factor X protein. RFXAP is part of the RFX complex, mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes []. |
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Protein Domain |
Type: |
Domain |
Description: |
This C-terminal domain of Regulatory factor X-associated protein (RFXAP) binds to RFXANK [, ], the ankyrin-repeat regulatory factor X protein. RFXAP is part of the RFX complex, mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes []. |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal domain of regulatory factor X (RFX)-5, which is part of the human RFX complex. The RFX complex (consists of RFX5, RFXAP and RFXB) is involved in the regulation of the expression of the major histocompatibility complex class II (MHCII) gene products essential for the initiation and regulation of the mammalian immune response. The N-terminal domain of RFX5 is responsible for homodimerization of RFX5 which promotes folding of the C-terminal domain of RFXAP. The folding of RFXAP results in the formation of a potential binding site for RFXB to bind to the MHCII promoter []. |
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Gene |
Type: |
gene |
Organism: |
human |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
231
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
204
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
231
 |
Fragment?: |
false |
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Publication |
First Author: |
Durand B |
Year: |
1997 |
Journal: |
EMBO J |
Title: |
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. |
Volume: |
16 |
Issue: |
5 |
Pages: |
1045-55 |
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Publication |
First Author: |
Nagarajan UM |
Year: |
1999 |
Journal: |
Immunity |
Title: |
RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. |
Volume: |
10 |
Issue: |
2 |
Pages: |
153-62 |
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Protein Domain |
Type: |
Domain |
Description: |
Transcription of all the members of MHCII family of genes is controlled by a set of conserved transcription factors and promoter elements. One of these class II transactivators is the DNA-binding RFX complex, which consists of subunits RFX5 and its accessory proteins RFXAP and RFXANK [].This entry represents the C-terminal domain of RFX5. The C-terminal domain mediates cooperative binding between the RFX complex and NF-Y, a transcription factor binding to the Y box sequence of MHC-II promoters []. |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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Publication |
First Author: |
Nekrep N |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex. |
Volume: |
20 |
Issue: |
12 |
Pages: |
4455-61 |
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Publication |
First Author: |
Masternak K |
Year: |
1998 |
Journal: |
Nat Genet |
Title: |
A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. |
Volume: |
20 |
Issue: |
3 |
Pages: |
273-7 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
90
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
105
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
95
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Fragment?: |
true |
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Publication |
First Author: |
Villard J |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y. |
Volume: |
20 |
Issue: |
10 |
Pages: |
3364-76 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
131
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1459
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
291
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
658
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
570
 |
Fragment?: |
false |
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