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Search results 101 to 191 out of 191 for Rfxap

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0.025s
Type Details Score
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287422
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Note: Expression was not detected in the digestive system.
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310096
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423420
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EN491; Specimen N308
Detected: false
Specimen Num: 1
Publication    
First Author: Strausberg R
Year: 2002
Journal: GenBank Submission
Title: Mus musculus, regulatory factor x-associated protein, clone MGC: 32426 IMAGE: 5041039, mRNA, complete cds
Pages: BC019935
Publication
First Author: Inoue S
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains.
Volume: 268
Issue: 2
Pages: 553-61
Publication
First Author: Hester M
Year: 2005
Journal: Mol Cell Biol
Title: Smad1 and Smad8 function similarly in mammalian central nervous system development.
Volume: 25
Issue: 11
Pages: 4683-92
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Laird KM
Year: 2010
Journal: J Mol Biol
Title: Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.
Volume: 403
Issue: 1
Pages: 40-51
Allele
Name: class II transactivator; targeted mutation 2, Walter Reith
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: class II transactivator; targeted mutation 1, Cheong-Hee Chang
Allele Type: Targeted
Attribute String: Null/knockout
Genotype
Symbol: Ciita/Ciita
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ciita/Ciita
Background: involves: 129S2/SvPas * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
DO Term
Protein Domain
Type: Homologous_superfamily
Description: This superfamily represents the C-terminal domain ofRFXAP (regulatory factor X-associated protein) that binds to RFXANK [, ], the ankyrin-repeat regulatory factor X protein. RFXAP is part of the RFX complex, mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes [].
Protein Domain
Type: Domain
Description: This C-terminal domain of Regulatory factor X-associated protein (RFXAP) binds to RFXANK [, ], the ankyrin-repeat regulatory factor X protein. RFXAP is part of the RFX complex, mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes [].
Protein Domain
Type: Domain
Description: This entry represents the N-terminal domain of regulatory factor X (RFX)-5, which is part of the human RFX complex. The RFX complex (consists of RFX5, RFXAP and RFXB) is involved in the regulation of the expression of the major histocompatibility complex class II (MHCII) gene products essential for the initiation and regulation of the mammalian immune response. The N-terminal domain of RFX5 is responsible for homodimerization of RFX5 which promotes folding of the C-terminal domain of RFXAP. The folding of RFXAP results in the formation of a potential binding site for RFXB to bind to the MHCII promoter [].
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
Publication
First Author: Durand B
Year: 1997
Journal: EMBO J
Title: RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.
Volume: 16
Issue: 5
Pages: 1045-55
Publication
First Author: Nagarajan UM
Year: 1999
Journal: Immunity
Title: RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency.
Volume: 10
Issue: 2
Pages: 153-62
Protein Domain
Type: Domain
Description: Transcription of all the members of MHCII family of genes is controlled by a set of conserved transcription factors and promoter elements. One of these class II transactivators is the DNA-binding RFX complex, which consists of subunits RFX5 and its accessory proteins RFXAP and RFXANK [].This entry represents the C-terminal domain of RFX5. The C-terminal domain mediates cooperative binding between the RFX complex and NF-Y, a transcription factor binding to the Y box sequence of MHC-II promoters [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Nekrep N
Year: 2000
Journal: Mol Cell Biol
Title: Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex.
Volume: 20
Issue: 12
Pages: 4455-61
Publication
First Author: Masternak K
Year: 1998
Journal: Nat Genet
Title: A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.
Volume: 20
Issue: 3
Pages: 273-7
Protein
Organism: Mus musculus/domesticus
Length: 90  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
Publication
First Author: Villard J
Year: 2000
Journal: Mol Cell Biol
Title: A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.
Volume: 20
Issue: 10
Pages: 3364-76
Protein
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1459  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 658  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false