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Search results 101 to 177 out of 177 for Rgs8

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Type Details Score
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
10092682 | J:54128
First Author: Saitoh O
Year: 1999
Journal: J Biol Chem
Title: RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents.
Volume: 274
Issue: 14
Pages: 9899-904
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Publication
20616094 | J:163324
First Author: Villasenor A
Year: 2010
Journal: Dis Model Mech
Title: Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes.
Volume: 3
Issue: 9-10
Pages: 567-80
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Publication
33553137 | J:336785
 
First Author: Wu QW
Year: 2020
Journal: Front Cell Dev Biol
Title: Modulation of Increased mGluR1 Signaling by RGS8 Protects Purkinje Cells From Dendritic Reduction and Could Be a Common Mechanism in Diverse Forms of Spinocerebellar Ataxia.
Volume: 8
Pages: 569889
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Allele
Tg(Rgs8-cre)OK14Gsat | MGI:5051791
Name: transgene insertion OK14, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5519926 | STOCK Tg(Rgs8-cre)OK14Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Rgs8-cre)OK14Gsat/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR033093 | ATXN2
Type: Family
Description: Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].
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Publication
29248457 | J:258268
First Author: Zolghadri Y
Year: 2018
Journal: Am J Pathol
Title: Malnutrition in Pancreatic Ductal Adenocarcinoma (PDA): Dietary Pancreatic Enzymes Improve Short-Term Health but Stimulate Tumor Growth.
Volume: 188
Issue: 3
Pages: 616-626
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Publication
18602463 | -
First Author: Nonis D
Year: 2008
Journal: Cell Signal
Title: Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
Volume: 20
Issue: 10
Pages: 1725-39
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Publication
8896555 | J:20378
First Author: Pulst SM
Year: 1996
Journal: Nat Genet
Title: Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
Volume: 14
Issue: 3
Pages: 269-76
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Publication
15342467 | -
First Author: Ciosk R
Year: 2004
Journal: Development
Title: ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.
Volume: 131
Issue: 19
Pages: 4831-41
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Publication
16293225 | J:103805
First Author: Kiehl TR
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Generation and characterization of Sca2 (ataxin-2) knockout mice.
Volume: 339
Issue: 1
Pages: 17-24
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Publication
29427103 | -
 
First Author: Scoles DR
Year: 2018
Journal: Adv Exp Med Biol
Title: Spinocerebellar Ataxia Type 2.
Volume: 1049
Pages: 175-195
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Protein Domain
IPR034949 | RGS_RGS8
Type: Domain
Description: The RGS (Regulator of G-protein Signalling) domain is an essential part of the RGS8 protein.RGS8 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS8 is involved in G-protein-gated potassium channels regulation [, ]and is predominantly expressed in the brain []. In the hematopoietic system, it is selectively expressed in natural killer (NK) cells [].
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Protein Domain
IPR025852 | SM_dom_ATX
Type: Domain
Description: This SM domain is found in Ataxin-2 [, ]. This domain has been shown to interact with RNA helicase DDX6 [].Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].
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Protein
J3QP59
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Protein
F6U209
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
A0A0G2JF15
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
F6U2Q5
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
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Protein
F6UTV7
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: true
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Publication
17392519 | -
First Author: Nonhoff U
Year: 2007
Journal: Mol Biol Cell
Title: Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
Volume: 18
Issue: 4
Pages: 1385-96
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Protein
Q7TQH0
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: false
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Protein
F6U2C2
Organism: Mus musculus/domesticus
Length: 929  
Fragment?: true
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Protein
F7B6X4
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: true
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Protein
Q3UX07
Organism: Mus musculus/domesticus
Length: 947  
Fragment?: true
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Protein
A0A0U1RPL0
Organism: Mus musculus/domesticus
Length: 1096  
Fragment?: false
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Protein
E9Q5Q0
Organism: Mus musculus/domesticus
Length: 863  
Fragment?: true
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Protein
Q3TYH7
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q3TGG2
Organism: Mus musculus/domesticus
Length: 994  
Fragment?: false
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Protein
F6V8M6
Organism: Mus musculus/domesticus
Length: 662  
Fragment?: true
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Protein
Q3UX51
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: true
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Publication
9462862 | -
First Author: Neuwald AF
Year: 1998
Journal: J Mol Med (Berl)
Title: Ataxin-2, global regulators of bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain.
Volume: 76
Issue: 1
Pages: 3-5
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Publication
9819425 | -
First Author: Mangus DA
Year: 1998
Journal: Mol Cell Biol
Title: Pbp1p, a factor interacting with Saccharomyces cerevisiae poly(A)-binding protein, regulates polyadenylation.
Volume: 18
Issue: 12
Pages: 7383-96
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Publication
15121841 | -
First Author: Mangus DA
Year: 2004
Journal: Mol Cell Biol
Title: Identification of factors regulating poly(A) tail synthesis and maturation.
Volume: 24
Issue: 10
Pages: 4196-206
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Publication
30982600 | -
First Author: Yang YS
Year: 2019
Journal: Cell
Title: Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth.
Volume: 177
Issue: 3
Pages: 697-710.e17
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Publication
18981231 | -
First Author: Buchan JR
Year: 2008
Journal: J Cell Biol
Title: P bodies promote stress granule assembly in Saccharomyces cerevisiae.
Volume: 183
Issue: 3
Pages: 441-55
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Protein
O70305
Organism: Mus musculus/domesticus
Length: 1285  
Fragment?: false
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Protein
E9QM77
Organism: Mus musculus/domesticus
Length: 1286  
Fragment?: false
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Protein
A0A0U1RNZ9
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
A0A286YDU2
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: true
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Publication
11917006 | -
First Author: Anantharaman V
Year: 2002
Journal: Nucleic Acids Res
Title: Comparative genomics and evolution of proteins involved in RNA metabolism.
Volume: 30
Issue: 7
Pages: 1427-64
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Publication
16115810 | -
First Author: Ralser M
Year: 2005
Journal: Hum Mol Genet
Title: Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Volume: 14
Issue: 19
Pages: 2893-909
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Publication
33802796 | -
 
First Author: López-Juárez ZM
Year: 2021
Journal: Int J Mol Sci
Title: The ATXN2 Orthologs CID3 and CID4, Act Redundantly to In-Fluence Developmental Pathways throughout the Life Cycle of Arabidopsis thaliana.
Volume: 22
Issue: 6
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Protein Domain
IPR009604 | LsmAD_domain
Type: Domain
Description: This domain can be found in eukaryotic ataxin-2 []. Ataxin-2 is predicted to consist of mostly non-globular domains []. This domain has been shown to interact with RNA helicase DDX6 [].Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].Proteins containing this domain also include Pbp1 from budding yeasts, Pbp1 interacts with Pab1 to regulate mRNA polyadenylation [, ]. It promotes mating-type switching in mother cells by positively regulating HO mRNA translation []and forms a condensate in response to respiratory status to regulate TORC1 signaling []. It is also involved in P-body-dependent granule assembly [].
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Protein Domain
IPR045117 | ATXN2-like
Type: Family
Description: This entry represents a group of RNA-binding proteins , including Ataxin-2 from animals, Pbp1 from fungi and Cid3/4 from Arabidopsis.Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].Pbp1 interacts with Pab1 to regulate mRNA polyadenylation [, ]. It promotes mating-type switching in mother cells by positively regulating HO mRNA translation []and forms a condensate in response to respiratory status to regulate TORC1 signalling []. It is also involved in P-body-dependent granule assembly [].Cid3/4 may have a role in developmental pathways throughout the life cycle of plants [].
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Publication
15082763 | -
First Author: Tadauchi T
Year: 2004
Journal: Mol Cell Biol
Title: Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex.
Volume: 24
Issue: 9
Pages: 3670-81
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Publication
24360541 | J:203555
First Author: Gerfen CR
Year: 2013
Journal: Neuron
Title: GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits.
Volume: 80
Issue: 6
Pages: 1368-83
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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