Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4885802 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-04-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266523 |
Pattern: |
Widespread |
Stage: |
TS23 |
Assay Id: |
MGI:4944919 |
Age: |
embryonic day 15.5 |
Image: |
g00356 E15.5 |
|
Specimen Label: |
g00356 E15.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4885802 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-04-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4944919 |
Age: |
embryonic day 15.5 |
Image: |
g00356 E15.5 |
Note: |
Expression was region specific and scattered. |
Specimen Label: |
g00356 E15.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4885802 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-04-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757728 |
Pattern: |
Widespread |
Stage: |
TS28 |
Assay Id: |
MGI:4944919 |
Age: |
postnatal day 7 |
Image: |
g00356 P7 |
|
Specimen Label: |
g00356 P7 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4885802 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-04-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757728 |
Pattern: |
Widespread |
Stage: |
TS28 |
Assay Id: |
MGI:4944919 |
Age: |
postnatal day 42 |
Image: |
g00356 Adult |
|
Specimen Label: |
g00356 Adult |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song JH |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. |
Volume: |
281 |
Issue: |
22 |
Pages: |
15361-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keresztes G |
Year: |
2003 |
Journal: |
Mol Cell Neurosci |
Title: |
Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system. |
Volume: |
24 |
Issue: |
3 |
Pages: |
687-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang N |
Year: |
2014 |
Journal: |
Nat Med |
Title: |
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease. |
Volume: |
20 |
Issue: |
5 |
Pages: |
536-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CK |
Year: |
2010 |
Journal: |
J Physiol |
Title: |
Replacing the rod with the cone transducin subunit decreases sensitivity and accelerates response decay. |
Volume: |
588 |
Issue: |
Pt 17 |
Pages: |
3231-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitsi V |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states. |
Volume: |
112 |
Issue: |
36 |
Pages: |
E5088-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoi F |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Abnormal nuclear envelopes in the striatum and motor deficits in DYT11 myoclonus-dystonia mouse models. |
Volume: |
21 |
Issue: |
4 |
Pages: |
916-25 |
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•
•
•
•
•
|
Publication |
First Author: |
Geddes CE |
Year: |
2018 |
Journal: |
Cell |
Title: |
Optogenetic Editing Reveals the Hierarchical Organization of Learned Action Sequences. |
Volume: |
174 |
Issue: |
1 |
Pages: |
32-43.e15 |
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•
•
•
•
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Publication |
First Author: |
Cui Y |
Year: |
2014 |
Journal: |
Nat Neurosci |
Title: |
Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. |
Volume: |
17 |
Issue: |
2 |
Pages: |
254-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dickey AS |
Year: |
2016 |
Journal: |
Nat Med |
Title: |
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. |
Volume: |
22 |
Issue: |
1 |
Pages: |
37-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie K |
Year: |
2016 |
Journal: |
Curr Biol |
Title: |
NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum. |
Volume: |
26 |
Issue: |
22 |
Pages: |
2992-3003 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sutton LP |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control. |
Volume: |
17 |
Issue: |
10 |
Pages: |
e3000477 |
|
•
•
•
•
•
|
Publication |
First Author: |
Radke AK |
Year: |
2017 |
Journal: |
Alcohol |
Title: |
Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptors subunit. |
Volume: |
58 |
|
Pages: |
47-51 |
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•
•
•
•
•
|
Publication |
First Author: |
Brigman JL |
Year: |
2013 |
Journal: |
Nat Neurosci |
Title: |
GluN2B in corticostriatal circuits governs choice learning and choice shifting. |
Volume: |
16 |
Issue: |
8 |
Pages: |
1101-10 |
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•
•
•
•
•
|
Publication |
First Author: |
Tsang SH |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase. |
Volume: |
26 |
Issue: |
17 |
Pages: |
4472-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson GR |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases. |
Volume: |
27 |
Issue: |
51 |
Pages: |
14117-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dang MT |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. |
Volume: |
103 |
Issue: |
41 |
Pages: |
15254-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2020 |
Journal: |
Neurobiol Dis |
Title: |
Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity. |
Volume: |
137 |
|
Pages: |
104746 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koralek AC |
Year: |
2012 |
Journal: |
Nature |
Title: |
Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. |
Volume: |
483 |
Issue: |
7389 |
Pages: |
331-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin X |
Year: |
2010 |
Journal: |
Nature |
Title: |
Start/stop signals emerge in nigrostriatal circuits during sequence learning. |
Volume: |
466 |
Issue: |
7305 |
Pages: |
457-62 |
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•
•
•
•
•
|
Publication |
First Author: |
Jin X |
Year: |
2014 |
Journal: |
Nat Neurosci |
Title: |
Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. |
Volume: |
17 |
Issue: |
3 |
Pages: |
423-30 |
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•
•
•
•
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Publication |
First Author: |
Muntean BS |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. |
Volume: |
34 |
Issue: |
5 |
Pages: |
108718 |
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•
•
•
•
|
Publication |
First Author: |
Liao GY |
Year: |
2013 |
Journal: |
Mol Metab |
Title: |
Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity. |
Volume: |
2 |
Issue: |
4 |
Pages: |
491-7 |
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•
•
•
•
|
Publication |
First Author: |
Garzón J |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization. |
Volume: |
280 |
Issue: |
10 |
Pages: |
8951-60 |
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•
•
•
•
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Publication |
First Author: |
Howard CD |
Year: |
2017 |
Journal: |
Neuron |
Title: |
Dynamic Nigrostriatal Dopamine Biases Action Selection. |
Volume: |
93 |
Issue: |
6 |
Pages: |
1436-1450.e8 |
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•
•
•
•
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Publication |
First Author: |
Urbanus BHA |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts. |
Volume: |
10 |
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1 |
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21631 |
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•
•
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•
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Publication |
First Author: |
Kool MJ |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. |
Volume: |
6 |
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Pages: |
26989 |
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•
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Publication |
First Author: |
Lobanova ES |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light. |
Volume: |
30 |
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20 |
Pages: |
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Publication |
First Author: |
Wilkes BJ |
Year: |
2021 |
Journal: |
Exp Neurol |
Title: |
Cell-specific effects of Dyt1 knock-out on sensory processing, network-level connectivity, and motor deficits. |
Volume: |
343 |
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113783 |
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2019 |
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eNeuro |
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The Role of BTBD9 in Striatum and Restless Legs Syndrome. |
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6 |
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5 |
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Publication |
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French CA |
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2019 |
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Mol Psychiatry |
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Differential effects of Foxp2 disruption in distinct motor circuits. |
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24 |
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3 |
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447-462 |
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Publication |
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Yokoi F |
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2011 |
Journal: |
PLoS One |
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Motor deficits and decreased striatal dopamine receptor 2 binding activity in the striatum-specific Dyt1 conditional knockout mice. |
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e24539 |
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Sutton LP |
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Biol Psychiatry |
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Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum. |
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80 |
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2023 |
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JCI Insight |
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Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors. |
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8 |
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13 |
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PLoS One |
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Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. |
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RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models. |
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Nat Neurosci |
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Voltage drives diverse endocannabinoid signals to mediate striatal microcircuit-specific plasticity. |
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Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
675
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
484
 |
Fragment?: |
false |
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Publication |
First Author: |
Nishiguchi KM |
Year: |
2004 |
Journal: |
Nature |
Title: |
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. |
Volume: |
427 |
Issue: |
6969 |
Pages: |
75-8 |
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DO Term |
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Publication |
First Author: |
Martemyanov KA |
Year: |
2003 |
Journal: |
J Neurosci |
Title: |
The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. |
Volume: |
23 |
Issue: |
32 |
Pages: |
10175-81 |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Allele |
Name: |
transgene insertion 1, Ching-Kang Chen |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
257
 |
Fragment?: |
false |
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Protein Domain |
Type: |
Family |
Description: |
This family consists of regulator of G-protein signalling 7-binding protein (RGS7BP) and regulator of G-protein signalling 9-binding protein (RGS9BP). They interact with regulation of G-protein signalling (RGS) proteins and Gbeta5 to form complexes that act to regulate G-proteins [].RGS7BP is expressed neuronally []and interacts with R7 family of RGS proteins (RGS6, RGS7, RGS9 and RGS11). RGS9BP interacts with RGS9 and is involved in the regulation of G-protein signalling in the phototransduction, participating in the recovery phase of visual transduction []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
237
 |
Fragment?: |
false |
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Publication |
First Author: |
Cheever ML |
Year: |
2008 |
Journal: |
Nat Struct Mol Biol |
Title: |
Crystal structure of the multifunctional Gbeta5-RGS9 complex. |
Volume: |
15 |
Issue: |
2 |
Pages: |
155-62 |
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Protein Domain |
Type: |
Domain |
Description: |
This domain is found in RGS9 (Class C) regulator of G-protein signalling (RGS) protein present in Mus musculus. RGS proteins attenuate heterotrimeric G-protein signalling by enhancing the intrinsic GTPase activity of G-alpha subunits and are vital for proper signal transduction kinetics. The domain is referred to as DEP helical extension (DHEX) because it is located next to N-terminal Dishevelled/Egl-10/Pleckstrin homology (DEP) domain. Both the DEP and DHEX domains are necessary, but not sufficient, to bind anchoring proteins such as RGS9 anchor protein. DHEX has no close structural homologues []. |
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Allele |
Name: |
guanine nucleotide binding protein (G protein), beta 5; targeted mutation 1, Ching-Kang Chen |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Publication |
First Author: |
Hu G |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP. |
Volume: |
278 |
Issue: |
16 |
Pages: |
14550-4 |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents regulator of G-protein signalling 9-binding protein (RGS9BP), which is involved in regulation of signalling in phototransduction []. It interacts with the regulation of G-protein signalling 9 (RGS9) and Gbeta5 complex, anchoring it to photoreceptor disc membranes [], enhancing the ability of RGS9 to stimulate G protein GTPase activity, allowing the visual signal to be terminated in a timely manner []. |
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Publication |
First Author: |
Cao Y |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. |
Volume: |
29 |
Issue: |
29 |
Pages: |
9301-13 |
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