| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:4885802 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266523 |
| Pattern: |
Widespread |
| Stage: |
TS23 |
| Assay Id: |
MGI:4944919 |
| Age: |
embryonic day 15.5 |
| Image: |
g00356 E15.5 |
|
| Specimen Label: |
g00356 E15.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885802 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4944919 |
| Age: |
embryonic day 15.5 |
| Image: |
g00356 E15.5 |
| Note: |
Expression was region specific and scattered. |
| Specimen Label: |
g00356 E15.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885802 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4944919 |
| Age: |
postnatal day 7 |
| Image: |
g00356 P7 |
|
| Specimen Label: |
g00356 P7 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885802 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4944919 |
| Age: |
postnatal day 42 |
| Image: |
g00356 Adult |
|
| Specimen Label: |
g00356 Adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Song JH |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. |
| Volume: |
281 |
| Issue: |
22 |
| Pages: |
15361-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Keresztes G |
| Year: |
2003 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system. |
| Volume: |
24 |
| Issue: |
3 |
| Pages: |
687-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang N |
| Year: |
2014 |
| Journal: |
Nat Med |
| Title: |
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease. |
| Volume: |
20 |
| Issue: |
5 |
| Pages: |
536-41 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Chen CK |
| Year: |
2010 |
| Journal: |
J Physiol |
| Title: |
Replacing the rod with the cone transducin subunit decreases sensitivity and accelerates response decay. |
| Volume: |
588 |
| Issue: |
Pt 17 |
| Pages: |
3231-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mitsi V |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states. |
| Volume: |
112 |
| Issue: |
36 |
| Pages: |
E5088-97 |
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•
•
•
•
•
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Yokoi F |
| Year: |
2012 |
| Journal: |
Hum Mol Genet |
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Abnormal nuclear envelopes in the striatum and motor deficits in DYT11 myoclonus-dystonia mouse models. |
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21 |
| Issue: |
4 |
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916-25 |
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•
•
•
•
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Geddes CE |
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2018 |
| Journal: |
Cell |
| Title: |
Optogenetic Editing Reveals the Hierarchical Organization of Learned Action Sequences. |
| Volume: |
174 |
| Issue: |
1 |
| Pages: |
32-43.e15 |
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•
•
•
•
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Cui Y |
| Year: |
2014 |
| Journal: |
Nat Neurosci |
| Title: |
Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. |
| Volume: |
17 |
| Issue: |
2 |
| Pages: |
254-61 |
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•
•
•
•
•
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| Publication |
| First Author: |
Dickey AS |
| Year: |
2016 |
| Journal: |
Nat Med |
| Title: |
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. |
| Volume: |
22 |
| Issue: |
1 |
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37-45 |
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•
•
•
•
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Xie K |
| Year: |
2016 |
| Journal: |
Curr Biol |
| Title: |
NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum. |
| Volume: |
26 |
| Issue: |
22 |
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2992-3003 |
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•
•
•
•
•
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| Publication |
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Sutton LP |
| Year: |
2019 |
| Journal: |
PLoS Biol |
| Title: |
NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control. |
| Volume: |
17 |
| Issue: |
10 |
| Pages: |
e3000477 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Radke AK |
| Year: |
2017 |
| Journal: |
Alcohol |
| Title: |
Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptors subunit. |
| Volume: |
58 |
|
| Pages: |
47-51 |
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•
•
•
•
•
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| Publication |
| First Author: |
Brigman JL |
| Year: |
2013 |
| Journal: |
Nat Neurosci |
| Title: |
GluN2B in corticostriatal circuits governs choice learning and choice shifting. |
| Volume: |
16 |
| Issue: |
8 |
| Pages: |
1101-10 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Tsang SH |
| Year: |
2006 |
| Journal: |
J Neurosci |
| Title: |
GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase. |
| Volume: |
26 |
| Issue: |
17 |
| Pages: |
4472-80 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Anderson GR |
| Year: |
2007 |
| Journal: |
J Neurosci |
| Title: |
Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases. |
| Volume: |
27 |
| Issue: |
51 |
| Pages: |
14117-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dang MT |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. |
| Volume: |
103 |
| Issue: |
41 |
| Pages: |
15254-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu J |
| Year: |
2020 |
| Journal: |
Neurobiol Dis |
| Title: |
Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity. |
| Volume: |
137 |
|
| Pages: |
104746 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koralek AC |
| Year: |
2012 |
| Journal: |
Nature |
| Title: |
Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. |
| Volume: |
483 |
| Issue: |
7389 |
| Pages: |
331-5 |
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•
•
•
•
•
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| Publication |
| First Author: |
Jin X |
| Year: |
2010 |
| Journal: |
Nature |
| Title: |
Start/stop signals emerge in nigrostriatal circuits during sequence learning. |
| Volume: |
466 |
| Issue: |
7305 |
| Pages: |
457-62 |
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•
•
•
•
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Jin X |
| Year: |
2014 |
| Journal: |
Nat Neurosci |
| Title: |
Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. |
| Volume: |
17 |
| Issue: |
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| Pages: |
423-30 |
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•
•
•
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Muntean BS |
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2021 |
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Cell Rep |
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Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. |
| Volume: |
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•
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Liao GY |
| Year: |
2013 |
| Journal: |
Mol Metab |
| Title: |
Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity. |
| Volume: |
2 |
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Garzón J |
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| Journal: |
J Biol Chem |
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Dynamic Nigrostriatal Dopamine Biases Action Selection. |
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Urbanus BHA |
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2020 |
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Sci Rep |
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Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts. |
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Kool MJ |
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| Journal: |
Sci Rep |
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The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. |
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6 |
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J Neurosci |
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Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light. |
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2021 |
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Cell-specific effects of Dyt1 knock-out on sensory processing, network-level connectivity, and motor deficits. |
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The Role of BTBD9 in Striatum and Restless Legs Syndrome. |
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PLoS One |
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| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
•
•
•
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| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
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•
•
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| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
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•
•
•
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| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
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•
•
•
•
•
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| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
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•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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•
•
•
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| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
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•
•
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| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
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•
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•
•
•
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| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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•
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•
•
•
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| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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•
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•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
675
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
484
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nishiguchi KM |
| Year: |
2004 |
| Journal: |
Nature |
| Title: |
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. |
| Volume: |
427 |
| Issue: |
6969 |
| Pages: |
75-8 |
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•
•
•
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| DO Term |
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•
•
•
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| Publication |
| First Author: |
Martemyanov KA |
| Year: |
2003 |
| Journal: |
J Neurosci |
| Title: |
The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. |
| Volume: |
23 |
| Issue: |
32 |
| Pages: |
10175-81 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Ching-Kang Chen |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
257
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family consists of regulator of G-protein signalling 7-binding protein (RGS7BP) and regulator of G-protein signalling 9-binding protein (RGS9BP). They interact with regulation of G-protein signalling (RGS) proteins and Gbeta5 to form complexes that act to regulate G-proteins [].RGS7BP is expressed neuronally []and interacts with R7 family of RGS proteins (RGS6, RGS7, RGS9 and RGS11). RGS9BP interacts with RGS9 and is involved in the regulation of G-protein signalling in the phototransduction, participating in the recovery phase of visual transduction []. |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
237
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheever ML |
| Year: |
2008 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
Crystal structure of the multifunctional Gbeta5-RGS9 complex. |
| Volume: |
15 |
| Issue: |
2 |
| Pages: |
155-62 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain is found in RGS9 (Class C) regulator of G-protein signalling (RGS) protein present in Mus musculus. RGS proteins attenuate heterotrimeric G-protein signalling by enhancing the intrinsic GTPase activity of G-alpha subunits and are vital for proper signal transduction kinetics. The domain is referred to as DEP helical extension (DHEX) because it is located next to N-terminal Dishevelled/Egl-10/Pleckstrin homology (DEP) domain. Both the DEP and DHEX domains are necessary, but not sufficient, to bind anchoring proteins such as RGS9 anchor protein. DHEX has no close structural homologues []. |
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•
•
•
•
•
|
| Allele |
| Name: |
guanine nucleotide binding protein (G protein), beta 5; targeted mutation 1, Ching-Kang Chen |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu G |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP. |
| Volume: |
278 |
| Issue: |
16 |
| Pages: |
14550-4 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents regulator of G-protein signalling 9-binding protein (RGS9BP), which is involved in regulation of signalling in phototransduction []. It interacts with the regulation of G-protein signalling 9 (RGS9) and Gbeta5 complex, anchoring it to photoreceptor disc membranes [], enhancing the ability of RGS9 to stimulate G protein GTPase activity, allowing the visual signal to be terminated in a timely manner []. |
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•
•
•
•
•
|
| Publication |
| First Author: |
Cao Y |
| Year: |
2009 |
| Journal: |
J Neurosci |
| Title: |
Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. |
| Volume: |
29 |
| Issue: |
29 |
| Pages: |
9301-13 |
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•
•
•
•
|