|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 216 for Rnf43

<< First    < Previous  |  Next >    Last >>
0.103s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12758
Specimen Label: GUDMAP:12758
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_06
Specimen Label: euxassay_007942_06
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_19
Specimen Label: euxassay_007942_19
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1683323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_13
Specimen Label: euxassay_007942_13
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:6421
Specimen Label: GUDMAP:6421
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12757
Specimen Label: GUDMAP:12757
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12758
Specimen Label: GUDMAP:12758
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2835527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5539968
Age: postnatal day 0
Image: GUDMAP:7728
Specimen Label: GUDMAP:7728
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:6421
Specimen Label: GUDMAP:6421
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12757
Specimen Label: GUDMAP:12757
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12758
Specimen Label: GUDMAP:12758
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:7596162
Assay Type: RNA in situ
Annotation Date: 2024-02-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3262722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7596256
Age: embryonic day 14.5
Note: Expression restricted to ectoderm.
Specimen Label: 2h Rnf43/Rspo2 (upper)
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:7596162
Assay Type: RNA in situ
Annotation Date: 2024-02-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3262722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7596256
Age: embryonic day 14.5
Note: Expression restricted to ectoderm.
Specimen Label: 2h Rnf43/Rspo2 (lower)
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:6421
Specimen Label: GUDMAP:6421
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5539968
Age: postnatal day 0
Image: GUDMAP:7728
Specimen Label: GUDMAP:7728
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12757
Specimen Label: GUDMAP:12757
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12758
Specimen Label: GUDMAP:12758
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_02
Specimen Label: euxassay_007942_02
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_03
Specimen Label: euxassay_007942_03
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_04
Specimen Label: euxassay_007942_04
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_05
Specimen Label: euxassay_007942_05
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_06
Specimen Label: euxassay_007942_06
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3820985
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827779
Age: embryonic day 14.5
Image: euxassay_007942_07
Specimen Label: euxassay_007942_07
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:6421
Specimen Label: GUDMAP:6421
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12757
Specimen Label: GUDMAP:12757
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12758
Specimen Label: GUDMAP:12758
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:6421
Specimen Label: GUDMAP:6421
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12757
Specimen Label: GUDMAP:12757
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:6421
Specimen Label: GUDMAP:6421
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12757
Specimen Label: GUDMAP:12757
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12758
Specimen Label: GUDMAP:12758
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:6421
Specimen Label: GUDMAP:6421
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3507006
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539968
Age: embryonic day 15.5
Image: GUDMAP:12757
Specimen Label: GUDMAP:12757
Detected: true
Specimen Num: 4
•
•
•
•
•
Publication
34995498 | J:321694
First Author: Lu C
Year: 2022
Journal: Stem Cell Reports
Title: RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
Volume: 17
Issue: 2
Pages: 369-383
•
•
•
•
•
Publication
34079124 | J:325755
First Author: Flanagan DJ
Year: 2021
Journal: Nature
Title: NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Volume: 594
Issue: 7863
Pages: 430-435
•
•
•
•
•
Publication
27088858 | J:236636
First Author: Planas-Paz L
Year: 2016
Journal: Nat Cell Biol
Title: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Volume: 18
Issue: 5
Pages: 467-79
•
•
•
•
•
Publication
29735715 | J:262492
First Author: Harris A
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.
Volume: 115
Issue: 21
Pages: 5474-5479
•
•
•
•
•
Publication
32324134 | J:290543
   
First Author: Vidal VP
Year: 2020
Journal: Elife
Title: R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors.
Volume: 9
•
•
•
•
•
Publication
27510977 | J:236406
First Author: Takada Y
Year: 2016
Journal: Development
Title: Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.
Volume: 143
Issue: 19
Pages: 3532-3539
•
•
•
•
•
Publication
28813421 | J:253067
First Author: Sigal M
Year: 2017
Journal: Nature
Title: Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Volume: 548
Issue: 7668
Pages: 451-455
•
•
•
•
•
Publication
17609113 | J:123923
First Author: Zhou Q
Year: 2007
Journal: Dev Cell
Title: A multipotent progenitor domain guides pancreatic organogenesis.
Volume: 13
Issue: 1
Pages: 103-14
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
•
•
•
•
•
Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
•
•
•
•
•
Publication
22988430 | J:190636
 
First Author: Wiese CB
Year: 2012
Journal: Front Neurosci
Title: A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Volume: 6
Pages: 130
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
•
•
•
•
•
Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
•
•
•
•
•
Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Protein
Q99KA9
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 24
Description: E3 ubiquitin-protein ligase RNF43
Type: chain
End: 784
•
•
•
•
•
Publication
25825523 | J:224398
First Author: Tsukiyama T
Year: 2015
Journal: Mol Cell Biol
Title: Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.
Volume: 35
Issue: 11
Pages: 2007-23
•
•
•
•
•
Publication
34390652 | J:315139
First Author: Niu J
Year: 2021
Journal: Neuron
Title: Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation.
Volume: 109
Issue: 19
Pages: 3104-3118.e6
•
•
•
•
•
Publication
21108931 | -
First Author: Shinada K
Year: 2011
Journal: Biochem Biophys Res Commun
Title: RNF43 interacts with NEDL1 and regulates p53-mediated transcription.
Volume: 404
Issue: 1
Pages: 143-7
•
•
•
•
•
Publication
25344691 | -
First Author: Giannakis M
Year: 2014
Journal: Nat Genet
Title: RNF43 is frequently mutated in colorectal and endometrial cancers.
Volume: 46
Issue: 12
Pages: 1264-6
•
•
•
•
•
Publication
23096461 | -
First Author: Ryland GL
Year: 2013
Journal: J Pathol
Title: RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary.
Volume: 229
Issue: 3
Pages: 469-76
•
•
•
•
•
Allele
Rnf43<em1Smoc> | MGI:7292090
Name: ring finger protein 43; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6429485 | C57BL/6JSmoc-Rnf43<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Publication
29018044 | -
First Author: Serra S
Year: 2018
Journal: J Clin Pathol
Title: Rnf43.
Volume: 71
Issue: 1
Pages: 1-6
•
•
•
•
•
Protein Domain
IPR045907 | RNF43_Znf_RING
Type: Domain
Description: This entry represents the RING-type zinc finger domain of E3 ubiquitin-protein ligase RNF43. Proteins containing this domain are found in vertebrates. RNF43 acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6 [, , ]. RNF43 also interacts with NEDD-4-like ubiquitin-protein ligase-1 (NEDL1) and regulates p53-mediated transcription []. It may also be involved in cell growth control potentially through the interaction with, a chromatin-associated protein interfacing the nuclear envelope []. Mutations of RNF43 have been identified in various tumours, including colorectal cancer (CRC), endometrial cancer, mucinous ovarian tumours, gastric adenocarcinoma, pancreatic ductal adenocarcinoma, liver fluke-associated cholangiocarcinoma, hepatocellular carcinoma, and glioma [, , ]. RNF43 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C3H2C3-type RING-H2 finger domain followed by a long C-terminal region [].In frogs (Xenopus), ZNRF3 and RNF43 were seen to play a key role in limb specification, constituting a master switch along with RSPO2, which may have implications for regenerative medicine [].
•
•
•
•
•
Publication
22575959 | J:184507
First Author: Hao HX
Year: 2012
Journal: Nature
Title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Volume: 485
Issue: 7397
Pages: 195-200
•
•
•
•
•
Publication
18313049 | -
First Author: Sugiura T
Year: 2008
Journal: Exp Cell Res
Title: A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.
Volume: 314
Issue: 7
Pages: 1519-28
•
•
•
•
•
Publication
30119997 | J:277045
First Author: Metidji A
Year: 2018
Journal: Immunity
Title: The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.
Volume: 49
Issue: 2
Pages: 353-362.e5
•
•
•
•
•
Publication
24609463 | J:212006
First Author: Fancy SP
Year: 2014
Journal: Nat Neurosci
Title: Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.
Volume: 17
Issue: 4
Pages: 506-12
•
•
•
•
•
Publication
29021137 | J:271423
First Author: Huang S
Year: 2017
Journal: Cancer Res
Title: DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
Volume: 77
Issue: 23
Pages: 6562-6575
•
•
•
•
•
Protein
A3KMI3
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
•
•
•
•
•
Protein
E9PWJ5
Organism: Mus musculus/domesticus
Length: 743  
Fragment?: false
•
•
•
•
•
Publication
31712448 | J:290404
First Author: Chan SC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Hepatocyte nuclear factor-1β regulates Wnt signaling through genome-wide competition with β-catenin/lymphoid enhancer binding factor.
Volume: 116
Issue: 48
Pages: 24133-24142
•
•
•
•
•
Publication
31170286 | J:289107
First Author: Mishra A
Year: 2020
Journal: Carcinogenesis
Title: Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing.
Volume: 41
Issue: 3
Pages: 334-344
•
•
•
•
•
Publication
30146491 | J:308689
First Author: Gyllborg D
Year: 2018
Journal: Stem Cell Reports
Title: The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.
Volume: 11
Issue: 3
Pages: 651-664
•
•
•
•
•
Publication
26123262 | -
First Author: Zebisch M
Year: 2015
Journal: J Struct Biol
Title: Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
Volume: 191
Issue: 2
Pages: 149-55
•
•
•
•
•
Publication
19238248 | -
First Author: Ayadi L
Year: 2008
Journal: Bioinformation
Title: Molecular modelling of the TSR domain of R-spondin 4.
Volume: 3
Issue: 3
Pages: 119-23
•
•
•
•
•
Publication
17041604 | J:116076
First Author: Blaydon DC
Year: 2006
Journal: Nat Genet
Title: The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.
Volume: 38
Issue: 11
Pages: 1245-7
•
•
•
•
•
Protein Domain
IPR042993 | RSPO2/4
Type: Family
Description: The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs [].RSPO2 is a secreted protein that belongs to the R-spondin (RSPO) family. Interestingly, it is one of the two members (RSPO2 and RSPO3) of the family capable of potentiating WNT signaling in cells lacking all three LGRs (Leucine-rich repeat-containing G-protein-coupled receptor 4/5/6) []. It plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form []. It has been shown to promote midbrain dopaminergic neurogenesis and differentiation in human stem cells []. Its structures in complex with the ectodomains of its receptors LGR5 and ZNRF3 have been revealed []. RSPO4 is a secreted protein that belongs to the R-spondin (RSPO) family. It has been associated with embryonic nail development [, ].
•
•
•
•
•
Publication
28467820 | J:252529
First Author: Yan KS
Year: 2017
Journal: Nature
Title: Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
Volume: 545
Issue: 7653
Pages: 238-242
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom