| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1646922 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1736222 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1683322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1700022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1832122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
| Note: |
Expression was detected in the immune system. |
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1741222 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3599822 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280922 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1833322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1821522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3557722 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1702122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1668822 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757722 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1738322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1802422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the skull (base and vault). |
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724896 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2672022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421547 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1490; Specimen C1536 |
| Note: |
Expression was weak in whisker follicle. |
| Specimen Label: |
MH1490; Specimen C1536 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiao S |
| Year: |
2002 |
| Journal: |
Annu Rev Biochem |
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Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. |
| Volume: |
71 |
|
| Pages: |
165-89 |
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•
•
•
•
•
|
| Publication |
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Mouse Genome Informatics Scientfic Curators |
| Year: |
2013 |
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| Title: |
Curated associations of genes in MGI and UniProt sequence records |
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•
•
•
•
•
|
| Publication |
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Hoffman BG |
| Year: |
2008 |
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Genome Biol |
| Title: |
Identification of transcripts with enriched expression in the developing and adult pancreas. |
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•
•
•
•
•
|
| Publication |
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Visel A |
| Year: |
2004 |
| Journal: |
Nucleic Acids Res |
| Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
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32 |
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Database issue |
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D552-6 |
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•
•
•
•
•
|
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Lennon G |
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1999 |
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Database Download |
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WashU-HHMI Mouse EST Project |
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•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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Nature |
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GemPharmatech Website. |
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2011 |
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Nature |
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AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
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Mouse T31 Radiation Hybrid Data Load |
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The Gene Ontology Consortium |
| Year: |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Database and National Center for Biotechnology Information |
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Allen Institute for Brain Science |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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•
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| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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2010 |
| Journal: |
Database Download |
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Consensus CDS project |
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•
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Mouse Genome Informatics Group |
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2003 |
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Automatic Encodes (AutoE) Reference |
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•
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Mouse Genome Informatics Scientific Curators |
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2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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Mouse Genome Informatics |
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•
•
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•
•
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| First Author: |
Mouse Genome Informatics Scientific Curators |
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2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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Jarrous N |
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RNA |
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Rpp14 and Rpp29, two protein subunits of human ribonuclease P. |
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153-7 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
150
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
51
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jarrous N |
| Year: |
2001 |
| Journal: |
RNA |
| Title: |
Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. |
| Volume: |
7 |
| Issue: |
8 |
| Pages: |
1153-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai T |
| Year: |
1999 |
| Journal: |
Mol Cell Biol |
| Title: |
Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation. |
| Volume: |
19 |
| Issue: |
11 |
| Pages: |
7857-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Houser-Scott F |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Interactions among the protein and RNA subunits of Saccharomyces cerevisiae nuclear RNase P. |
| Volume: |
99 |
| Issue: |
5 |
| Pages: |
2684-9 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry contains ribonuclease P (Rnp) proteins from eukaryotes and archaea. Rnp is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) [, ]. Archaeal and eukaryotic RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic RNase P consists of 9 or 10 proteins. Eukaryotic and archaeal RNase P RNAs cooperatively function with protein subunits in catalysis []. Human RNase P is composed of a singular protein Pop1 and three subcomplexes, the Rpp20-Rpp25 heterodimer, Pop5-Rpp14-(Rpp30)2-Rpp40 heteropentamer, and Rpp21-Rpp29-Rpp38 heterotrimer. Although both Pop5 and Rpp14 have similar protein structure, they share a very limited sequence similarity. Moreover, the C-terminal fragments after the conserved beta sheets in Pop5 and Rpp14 exhibit distinct structural features that mediate interactions with Pop1 and Rpp40, respectively [].In the hyperthermophilic archaeon Pyrococcus horikoshii OT3, RNase P is composed of the RNase P RNA (pRNA) and five proteins (PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30) [, ].This entry includes Rpp21 from animals, Snm1/Rpr2 from yeasts and RNP4 from archaea [, ]. Snm1 is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. Snm1 is an RNA binding protein that binds the MRP RNA specifically []. This subunit possibly binds the precursor tRNA []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry contains ribonuclease P (Rnp) proteins from eukaryotes and archaea. Rnp is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) [, ]. Archaeal and eukaryotic RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic RNase P consists of 9 or 10 proteins. Eukaryotic and archaeal RNase P RNAs cooperatively function with protein subunits in catalysis []. Human RNase P is composed of a singular protein Pop1 and three subcomplexes, the Rpp20-Rpp25 heterodimer, Pop5-Rpp14-(Rpp30)2-Rpp40 heteropentamer, and Rpp21-Rpp29-Rpp38 heterotrimer. Although both Pop5 and Rpp14 have similar protein structure, they share a very limited sequence similarity. Moreover, the C-terminal fragments after the conserved beta sheets in Pop5 and Rpp14 exhibit distinct structural features that mediate interactions with Pop1 and Rpp40, respectively [].In the hyperthermophilic archaeon Pyrococcus horikoshii OT3, RNase P is composed of the RNase P RNA (pRNA) and five proteins (PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30) [, ].Proteins in this entry include Rnp2 (also known as Pop5) from archaea and Pop5/Rpp14 from humans []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
122
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lan P |
| Year: |
2018 |
| Journal: |
Science |
| Title: |
Structural insight into precursor tRNA processing by yeast ribonuclease P. |
| Volume: |
362 |
| Issue: |
6415 |
|
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
This superfamily contains ribonuclease P (Rnp) proteins from eukaryotes and archaea. Rnp is a ubiquitous ribozyme that catalyzes a Mg2+-dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) []. Archaeal and eukaryote RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic RNase P consists of 9 or 10 proteins. Eukaryotic and archaeal RNase P RNAs cooperatively function with protein subunits in catalysis []. Eukaryotic nuclear RNase P shares most of its protein components with another essential RNP enzyme, nucleolar RNase MRP []. RNase MRP (mitochondrial RNA processing) is an rRNA processing enzyme that cleaves a specific site within precursor rRNA to generate the mature 5'-end of 5.8S rRNA []. Despite its name, the vast majority of RNase MRP is localized in the nucleolus []. RNase MRP has been shown to cleave primers for mitochondrial DNA replication and CLB2 mRNA. In yeast, RNase MRP possesses one putatively catalytic RNA and at least 9 protein subunits (Pop1, Pop3-Pop8, Rpp1, Snm1 and Rmp1) [].Human RNase P is composed of a singular protein Pop1 and three subcomplexes, the Rpp20-Rpp25 heterodimer, Pop5-Rpp14-(Rpp30)2-Rpp40 heteropentamer, and Rpp21-Rpp29-Rpp38 heterotrimer [].In the hyperthermophilic archaeon Pyrococcus horikoshii OT3, RNase P is composed of the RNase P RNA (pRNA) and five proteins (PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30) [, ].Proteins in this entry include Rnp2 (also known as Pop5) from archaea and Pop5/Rpp14 from humans. In eukaryotes Pop5 is a subunit of both the Rnp and MRP complexes. Although both Pop5 and Rpp14 have similar protein structure, they share a very limited sequence similarity. Moreover, the C-terminal fragments after the conserved beta sheets in Pop5 and Rpp14 exhibit distinct structural features that mediate interactions with Pop1 and Rpp40, respectively [].The structure of Rnp2 (ribonuclease P protein component 2) has a ferrodoxin-like fold composed of an α-β sandwich with antiparallel β-sheet and contains an extra C-terminal helix. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Terada A |
| Year: |
2006 |
| Journal: |
J Biochem |
| Title: |
Characterization of the archaeal ribonuclease P proteins from Pyrococcus horikoshii OT3. |
| Volume: |
140 |
| Issue: |
2 |
| Pages: |
293-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kimura M |
| Year: |
2017 |
| Journal: |
Biosci Biotechnol Biochem |
| Title: |
Structural basis for activation of an archaeal ribonuclease P RNA by protein cofactors. |
| Volume: |
81 |
| Issue: |
9 |
| Pages: |
1670-1680 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
169
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bussey H |
| Year: |
1995 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. |
| Volume: |
92 |
| Issue: |
9 |
| Pages: |
3809-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Walker SC |
| Year: |
2005 |
| Journal: |
Biochem Soc Trans |
| Title: |
Probing the structure of Saccharomyces cerevisiae RNase MRP. |
| Volume: |
33 |
| Issue: |
Pt 3 |
| Pages: |
479-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marvin MC |
| Year: |
2011 |
| Journal: |
RNA |
| Title: |
Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae. |
| Volume: |
17 |
| Issue: |
8 |
| Pages: |
1441-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Esakova O |
| Year: |
2010 |
| Journal: |
RNA |
| Title: |
Of proteins and RNA: the RNase P/MRP family. |
| Volume: |
16 |
| Issue: |
9 |
| Pages: |
1725-47 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gopalan V |
| Year: |
2018 |
| Journal: |
RNA |
| Title: |
Chance and necessity in the evolution of RNase P. |
| Volume: |
24 |
| Issue: |
1 |
| Pages: |
1-5 |
|
•
•
•
•
•
|