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Search results 101 to 192 out of 192 for Ruvbl2

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0.024s
Type Details Score
GXD Expression  
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827840
Age: embryonic day 14.5
Image: euxassay_002276_04
Specimen Label: euxassay_002276_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827840
Age: embryonic day 14.5
Image: euxassay_002276_05
Specimen Label: euxassay_002276_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827840
Age: embryonic day 14.5
Image: euxassay_002276_19
Specimen Label: euxassay_002276_19
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827840
Age: embryonic day 14.5
Image: euxassay_002276_20
Specimen Label: euxassay_002276_20
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827840
Age: embryonic day 14.5
Image: euxassay_002276_21
Specimen Label: euxassay_002276_21
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827840
Age: embryonic day 14.5
Image: euxassay_002276_24
Specimen Label: euxassay_002276_24
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7463913
Age: embryonic day 9.5
Specimen Label: Table S1 E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7463913
Age: embryonic day 10.5
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116919
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463913
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3589915
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:7463913
Age: embryonic day 9.5
Note: Expression was in external genitalia.
Specimen Label: Table S1 E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1636715
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:4848594
Age: embryonic day 9.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1627215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848594
Age: embryonic day 9.5
Note: Staining is present in the hyoid arch.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1627217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848594
Age: embryonic day 10.5
Note: Staining is present in the hyoid arch.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1627219
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848594
Age: embryonic day 11.5
Note: Staining is present in the hyoid arch.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3589023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827840
Age: embryonic day 14.5
Image: euxassay_002276_07
Specimen Label: euxassay_002276_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848594
Age: embryonic day 10.5
Note: Staining is present in the otic pit.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7463913
Age: embryonic day 10.5
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666919
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463913
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2023-09-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530759
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1050632
Assay Type: RNA in situ
Annotation Date: 2024-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7711561
Age: embryonic day 14.5
Specimen Label: Supplementary Table 3
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7463913
Age: embryonic day 9.5
Specimen Label: Table S1 E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7463913
Age: embryonic day 10.5
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611719
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463913
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1618415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848594
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1618417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848594
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1618419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848594
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1654315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848594
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7463913
Age: embryonic day 9.5
Specimen Label: Table S1 E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7463913
Age: embryonic day 10.5
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1638815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848594
Age: embryonic day 9.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844729
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848594
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
Publication
First Author: McKeegan KS
Year: 2007
Journal: Mol Cell Biol
Title: A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.
Volume: 27
Issue: 19
Pages: 6782-93
Publication
First Author: Hattori A
Year: 2023
Journal: Leukemia
Title: Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia.
Volume: 37
Issue: 9
Pages: 1812-1829
Publication
First Author: Dafinger C
Year: 2018
Journal: Exp Mol Med
Title: Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.
Volume: 50
Issue: 6
Pages: 75
Publication
First Author: Hosokawa H
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.
Volume: 110
Issue: 46
Pages: 18626-31
Publication
First Author: Ruhl DD
Year: 2006
Journal: Biochemistry
Title: Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes.
Volume: 45
Issue: 17
Pages: 5671-7
Publication  
First Author: Tarangelo A
Year: 2015
Journal: Nat Commun
Title: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression.
Volume: 6
Pages: 10028
Publication
First Author: de Planell-Saguer M
Year: 2009
Journal: Hum Mol Genet
Title: Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.
Volume: 18
Issue: 12
Pages: 2115-26
Publication
First Author: Min JN
Year: 2013
Journal: Cell Res
Title: The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability.
Volume: 23
Issue: 12
Pages: 1396-413
Publication
First Author: Doyon Y
Year: 2004
Journal: Mol Cell Biol
Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
Volume: 24
Issue: 5
Pages: 1884-96
Publication
First Author: Jacquet K
Year: 2016
Journal: Mol Cell
Title: The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Volume: 62
Issue: 3
Pages: 409-421
Publication
First Author: Muzio L
Year: 2005
Journal: Cereb Cortex
Title: A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus.
Volume: 15
Issue: 12
Pages: 2021-8
Publication
First Author: Ravasi T
Year: 2010
Journal: Cell
Title: An atlas of combinatorial transcriptional regulation in mouse and man.
Volume: 140
Issue: 5
Pages: 744-52
Publication  
First Author: Elsen GE
Year: 2018
Journal: Front Neurosci
Title: The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.
Volume: 12
Pages: 571
Publication      
First Author: Mager J
Year: 2019
Journal: MGI Direct Data Submission
Title: A Catalog of Early Lethal KOMP Phenotypes
Publication
First Author: Shimizu H
Year: 2013
Journal: PLoS One
Title: The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.
Volume: 8
Issue: 10
Pages: e75754
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Rajendra E
Year: 2014
Journal: Nucleic Acids Res
Title: Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases.
Volume: 42
Issue: 22
Pages: 13736-48
Publication
First Author: Cirilli M
Year: 2017
Journal: Biochim Biophys Acta
Title: Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.
Volume: 1861
Issue: 2
Pages: 467-476
Publication
First Author: Matias PM
Year: 2006
Journal: J Biol Chem
Title: Crystal structure of the human AAA+ protein RuvBL1.
Volume: 281
Issue: 50
Pages: 38918-29
Protein Domain
Type: Homologous_superfamily
Description: RuvBL1 is a ubiquitously expressed protein that plays important roles in chromatin remodeling, transcription, DNA repair, and apoptosis. The significant evolutionary conservation of RuvBL1 from yeast to man strongly suggests that it mediates important cellular functions. RuvBL1 belongs to a large family of ATPases known as AAA proteins (ATPases associated with diverse cellular activities) which generally form hexamers. RuvBL1 is the eukaryotic homologue of the bacterial DNA-dependent ATPase and helicase RuvB [].RuvB-like helicase 2 (RUVBL2 or TIP49b; ) has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It forms a homohexamer which is critical for ATP hydrolysis, and forms a dodecamer with RUVBL1 [, ]. RUVBL2 is an essential cofactor for oncogenic transformation by c-Myc []. It is a component of the NuA4 histone acetyltransferase [], BAF53 [], MLL1/MLL [], INO80 []and R2TP []complexes.This entry represents the second domain of RuvBL1 and RUVB2 which is involved in DNA/RNA binding [].
Protein Domain
Type: Family
Description: RuvB-like helicase 1 (RUVBL1 or TIP49a; ) has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It forms a homohexamer which is critical for ATP hydrolysis, and forms a dodecamer with RUVBL2 [, ]. RUVBL1 is an essential cofactor for oncogenic transformation by c-Myc []. It is a component of the NuA4 histone acetyltransferase [], BAF53 [], MLL1/MLL [], INO80 []and R2TP []complexes.The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
Protein
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false