Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603915 |
Pattern: |
Ubiquitous |
Stage: |
TS15 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 9.5 |
|
Note: |
There is higher expression in areas with more rapid proliferation and differentiation processes. |
Specimen Label: |
S2C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603915 |
Pattern: |
Ubiquitous |
Stage: |
TS15 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 9.5 |
|
Note: |
There is higher expression in areas with more rapid proliferation and differentiation processes. |
Specimen Label: |
S2D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3185813 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 8.5 |
|
Note: |
Expression is in the outer regions. |
Specimen Label: |
S2A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3185813 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 8.5 |
|
Note: |
Expression is in the outer regions. |
Specimen Label: |
S2B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3116915 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
S2H |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666915 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
S2G |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615955 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-28 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3618080 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615955 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-28 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754027 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3618080 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615955 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-28 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280927 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3618080 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160465 |
Pattern: |
Not Specified |
Stage: |
TS05 |
Assay Id: |
MGI:6835793 |
Age: |
embryonic day 3.5 |
|
Note: |
Expression is nuclear. |
Specimen Label: |
S3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615955 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-28 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267921 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3618080 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615955 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-28 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3618080 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615955 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-28 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3618080 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160362 |
Pattern: |
Not Specified |
Stage: |
TS02 |
Assay Id: |
MGI:6835793 |
Age: |
embryonic day 1.0 |
|
|
Specimen Label: |
not shown 2-cell |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3800315 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression is in the anterior and posterior neuropore. |
Specimen Label: |
S2C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3800315 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression is in the anterior and posterior neuropore. |
Specimen Label: |
S2D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6835788 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3800315 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:6835789 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression is in the anterior neuropore. |
Specimen Label: |
S2E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2011 |
Journal: |
Blood |
Title: |
TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. |
Volume: |
117 |
Issue: |
21 |
Pages: |
5643-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whitmill A |
Year: |
2017 |
Journal: |
Stem Cells |
Title: |
Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2. |
Volume: |
35 |
Issue: |
7 |
Pages: |
1674-1686 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mager J |
Year: |
2019 |
Journal: |
MGI Direct Data Submission |
Title: |
A Catalog of Early Lethal KOMP Phenotypes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
McKee AE |
Year: |
2005 |
Journal: |
BMC Dev Biol |
Title: |
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. |
Volume: |
5 |
|
Pages: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
962
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Harada K |
Year: |
2001 |
Journal: |
Int J Cancer |
Title: |
Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation. |
Volume: |
93 |
Issue: |
5 |
Pages: |
623-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
401
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Matz A |
Year: |
2015 |
Journal: |
Cell Death Differ |
Title: |
Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. |
Volume: |
22 |
Issue: |
4 |
Pages: |
626-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang D |
Year: |
1999 |
Journal: |
Cancer Res |
Title: |
Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients. |
Volume: |
59 |
Issue: |
16 |
Pages: |
4056-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. |
Volume: |
277 |
Issue: |
26 |
Pages: |
23854-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Medenbach J |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling. |
Volume: |
24 |
Issue: |
17 |
Pages: |
7392-401 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the RNA recognition motif 1 (RRM1) of SART3 (also known as Tip110), which is an RNA-binding protein expressed in the nucleus of the majority of proliferating cells, including normal cells and malignant cells, but not in normal tissues except for the testes and fetal liver []. It is involved in the regulation of mRNA splicing probably via its complex formation with RNPS1 (an RNA-binding protein with a serine-rich domain), a pre-mRNA-splicing factor []. SART3 has also been identified as a nuclear Tat-interacting protein that regulates Tat transactivation activity through direct interaction and functions as an important cellular factor for HIV-1 gene expression and viral replication []. In addition, SART3 is required for U6 snRNP targeting to Cajal bodies []. It binds specifically and directly to the U6 snRNA, interacts transiently with the U6 and U4/U6 snRNPs, and promotes the reassembly of U4/U6 snRNPs after splicing in vitro [].SART3 contains an N-terminal HAT (half-a-tetratricopeptide repeat)-rich domain, a nuclearlocalization signal (NLS) domain, and two C-terminal RNA recognition motifs (RRMs). |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the RNA recognition motif 2 (RRM2) of SART3 (also known as Tip110), which is an RNA-binding protein expressed in the nucleus of the majority of proliferating cells, including normal cells and malignant cells, but not in normal tissues except for the testes and fetal liver []. It is involved in the regulation of mRNA splicing probably via its complex formation with RNPS1 (an RNA-binding protein with a serine-rich domain), a pre-mRNA-splicing factor []. SART3 has also been identified as a nuclear Tat-interacting protein that regulates Tat transactivation activity through direct interaction and functions as an important cellular factor for HIV-1 gene expression and viral replication []. In addition, SART3 is required for U6 snRNP targeting to Cajal bodies []. It binds specifically and directly to the U6 snRNA, interacts transiently with the U6 and U4/U6 snRNPs, and promotes the reassembly of U4/U6 snRNPs after splicing in vitro [].SART3 contains a HAT (N-terminal half-a-tetratricopeptide repeat)-rich domain, a nuclearlocalization signal (NLS) domain, and two C-terminal RNA recognition motifs (RRMs). |
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Publication |
First Author: |
Jiao J |
Year: |
2009 |
Journal: |
Biochim Biophys Acta |
Title: |
Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. |
Volume: |
1792 |
Issue: |
10 |
Pages: |
1027-35 |
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Publication |
First Author: |
Pratelli R |
Year: |
2012 |
Journal: |
Plant Physiol |
Title: |
The ubiquitin E3 ligase LOSS OF GDU2 is required for GLUTAMINE DUMPER1-induced amino acid secretion in Arabidopsis. |
Volume: |
158 |
Issue: |
4 |
Pages: |
1628-42 |
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Publication |
First Author: |
Pérez-Oliva AB |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. |
Volume: |
284 |
Issue: |
46 |
Pages: |
31714-25 |
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Publication |
First Author: |
Kim BY |
Year: |
2007 |
Journal: |
Mol Biol Cell |
Title: |
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. |
Volume: |
18 |
Issue: |
4 |
Pages: |
1129-42 |
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Publication |
First Author: |
Chhangani D |
Year: |
2013 |
Journal: |
Sci Rep |
Title: |
Mahogunin ring finger-1 (MGRN1) suppresses chaperone-associated misfolded protein aggregation and toxicity. |
Volume: |
3 |
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Pages: |
1972 |
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Publication |
First Author: |
Mukherjee R |
Year: |
2017 |
Journal: |
Traffic |
Title: |
MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport. |
Volume: |
18 |
Issue: |
12 |
Pages: |
791-807 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
 |
Fragment?: |
true |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represent the C3HC5-type RING-HC finger found in MGRN1/RNF157 and related proteins. It is distinguished from typical C3HC4 RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.MGRN1 is a cytosolic E3 ubiquitin-protein ligase that inhibits signalling through the G protein-coupled melanocortin receptors-1 (MC1R), -2 (MC2R) and -4 (MC4R) via ubiquitylation-dependent and -independent processes []. It suppresses chaperone-associated misfolded protein aggregation and toxicity []. MGRN1 interacts with cytosolic prion proteins (PrPs) that are linked with neurodegeneration[]. It also interacts with expanded polyglutamine proteins, and suppresses misfolded polyglutamine aggregation and cytotoxicity. Moreover, MGRN1 inhibits melanocortin receptor signaling by competition with Galphas, suggesting a novel pathway for melanocortin signaling from the cell surface to the nucleus []. Furthermore, MGRN1 interacts with and ubiquitylates TSG101, a key component of the endosomal sorting complex required for transport (ESCRT)-I, and regulates endosomal trafficking. A null mutation in the gene encoding MGRN1 causes spongiform neurodegeneration, suggesting a link between dysregulation of endosomal trafficking and spongiform neurodegeneration [, ].RNF157 is a cytoplasmic E3 ubiquitin ligase predominantly expressed in brain. In cultured neurons, it promotes neuronal survival in an E3 ligase-dependent manner. In contrast, it supports growth and maintenance of dendrites independent of its E3 ligase activity. RNF157 interacts with and ubiquitinates the adaptor protein APBB1 (amyloid beta precursor protein-binding, family B, member 1 or Fe65), which regulates neuronal survival, but not dendritic growth downstream of RNF157. The nuclear localization of APBB1 together with its interaction partner RNA-binding protein SART3 (squamous cell carcinoma antigen recognized by T cells 3 or Tip110) is crucial to trigger apoptosis []. Both MGRN1 and RNF157 contain a modified C3HC5-type RING-HC finger, and a functionally uncharacterized region, known as domain associated with RING2 (DAR2), N-terminal to the RING finger.In Arabidopsis, LOG2 is a predicted E3 ubiquitin ligase that interact with GDU1 and is involved in the regulation of amino acid export from plant cells []. |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of confirmed and predicted E3 ubiquitin ligases, including MGRN1/RNF157 from humans and LOG2/LUL1-4 from Arabidopsis.MGRN1 is a cytosolic E3 ubiquitin-protein ligase that inhibits signalling through the G protein-coupled melanocortin receptors-1 (MC1R), -2 (MC2R) and -4 (MC4R) via ubiquitylation-dependent and -independent processes []. It suppresses chaperone-associated misfolded protein aggregation and toxicity []. MGRN1 interacts with cytosolic prion proteins (PrPs) that are linked with neurodegeneration[]. It also interacts with expanded polyglutamine proteins, and suppresses misfolded polyglutamine aggregation and cytotoxicity. Moreover, MGRN1 inhibits melanocortin receptor signaling by competition with Galphas, suggesting a novel pathway for melanocortin signaling from the cell surface to the nucleus []. Furthermore, MGRN1 interacts with and ubiquitylates TSG101, a key component of the endosomal sorting complex required for transport (ESCRT)-I, and regulates endosomal trafficking. A null mutation in the gene encoding MGRN1 causes spongiform neurodegeneration, suggesting a link between dysregulation of endosomal trafficking and spongiform neurodegeneration [, ].RNF157 is a cytoplasmic E3 ubiquitin ligase predominantly expressed in brain. In cultured neurons, it promotes neuronal survival in an E3 ligase-dependent manner. In contrast, it supports growth and maintenance of dendrites independent of its E3 ligase activity. RNF157 interacts with and ubiquitinates the adaptor protein APBB1 (amyloid beta precursor protein-binding, family B, member 1 or Fe65), which regulates neuronal survival, but not dendritic growth downstream of RNF157. The nuclear localization of APBB1 together with its interaction partner RNA-binding protein SART3 (squamous cell carcinoma antigen recognized by T cells 3 or Tip110) is crucial to trigger apoptosis []. Both MGRN1 and RNF157 contain a modified C3HC5-type RING-HC finger, and a functionally uncharacterized region, known as domain associated with RING2 (DAR2), N-terminal to the RING finger.In Arabidopsis, LOG2 is a predicted E3 ubiquitin ligase that interact with GDU1 and is involved in the regulation of amino acid export from plant cells []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
685
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
506
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
506
 |
Fragment?: |
true |
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
681
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
659
 |
Fragment?: |
false |
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