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Search results 101 to 108 out of 108 for Scaf8

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0.028s

Type

Details

Score

Allele

Del(17Scaf8-Pde10a)15Yey | MGI:7509492

Name:	deletion, chromosome 17, Y Yu; deletion, chromosome 17, Y Yu 15
Allele Type:	Targeted
Attribute String:	Null/knockout

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Protein Domain

IPR034370 | SCAF8_RRM

Type:

Domain

Description:

This entry represents the RNA recognition motif (RRM) of SCAF8, a nuclear matrix protein that interacts specifically with a highly serine-phosphorylated form of the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (pol II) []. The pol II CTD plays a role in coupling transcription and pre-mRNA processing []. SCAF8 co-localizes primarily with transcription sites that are enriched in nuclear matrix fraction, which is known to contain proteins involved in pre-mRNA processing []. Thus, SCAF8 may play a direct role in coupling with both, transcription and pre-mRNA processing, processes. SCAF8, together with SCAF4, represents a new class of SCAFs (SR-like CTD-associated factors). They contain a conserved N-terminal CTD-interacting domain (CID), an atypical RNA recognition motif (RRM) and serine/arginine-rich motifs.

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Strain

MGI:7509494 | STOCK Del(17Scaf8-Pde10a)15Yey/J

Attribute String:

deletion, mutant stock, targeted mutation

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Genotype

Symbol:	Del(17Scaf8-Pde10a)15Yey/+ Ts(17<16>)65Dn/?
Background:	involves: 129S7/SvEvBrd * DBA/2J
Zygosity:	cx
Has Mutant Allele:	true

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Publication

37014740 | J:337878

First Author:	Xing Z
Year:	2023
Journal:	Hum Mol Genet
Title:	Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome.
Volume:	32
Issue:	13
Pages:	2205-2218

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Protein

Q6DID3

Organism:	Mus musculus/domesticus
Length:	1268
Fragment?:	false

•

Protein

Q7TSH6

Organism:	Mus musculus/domesticus
Length:	1183
Fragment?:	false

•

Protein

Q3TBS5

Organism:	Mus musculus/domesticus
Length:	705
Fragment?:	true

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