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Search results 101 to 178 out of 178 for Scap

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Type Details Score
Publication
11842132 | J:72264
First Author: Wittenburg H
Year: 2002
Journal: Physiol Genomics
Title: Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice.
Volume: 8
Issue: 1
Pages: 67-77
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Publication
14592843 | J:86340
First Author: Korstanje R
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice.
Volume: 24
Issue: 1
Pages: 155-60
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Publication
14662765 | J:88490
First Author: Beigneux AP
Year: 2004
Journal: J Biol Chem
Title: ATP-citrate lyase deficiency in the mouse.
Volume: 279
Issue: 10
Pages: 9557-64
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Publication
30604742 | J:270164
First Author: Guo M
Year: 2019
Journal: Nat Commun
Title: Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth.
Volume: 10
Issue: 1
Pages: 37
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Publication
- | J:82718
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Download
Title: MGI cDNA Clone Load
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Publication
- | J:175597
     
First Author: Overbeek PA
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Overbeek Lentiviral Transgenic Lines
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Publication
16783635 | J:109795
First Author: Kenney-Hunt JP
Year: 2006
Journal: Mamm Genome
Title: Quantitative trait loci for body size components in mice.
Volume: 17
Issue: 6
Pages: 526-37
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Publication
15582152 | J:102103
First Author: Jensen P
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A neurogenomics approach to gene expression analysis in the developing brain.
Volume: 132
Issue: 2
Pages: 116-27
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
33718362 | J:314058
 
First Author: Kong M
Year: 2021
Journal: Front Cell Dev Biol
Title: The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes.
Volume: 9
Pages: 622866
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Publication
34487377 | J:350943
First Author: Liu F
Year: 2021
Journal: EMBO J
Title: PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
Volume: 40
Issue: 22
Pages: e108065
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CL Term
CL:4040005 | mesenchymal stem cell of apical papilla
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Interaction Experiment
Yan R (2021)
Description: Structural basis for sterol sensing by Scap and Insig.
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Allele
Scap<em2Smoc> | MGI:7292177
Name: SREBF chaperone; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
34192549 | -
First Author: Yan R
Year: 2021
Journal: Cell Rep
Title: Structural basis for sterol sensing by Scap and Insig.
Volume: 35
Issue: 13
Pages: 109299
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Publication
32111832 | J:287088
First Author: Loregger A
Year: 2020
Journal: Nat Commun
Title: Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Volume: 11
Issue: 1
Pages: 1128
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Strain
MGI:7718242 | C57BL/6JSmoc-Scap<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Scap<em1Smoc> | MGI:7292176
Name: SREBF chaperone; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
12193656 | -
First Author: Espenshade PJ
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER.
Volume: 99
Issue: 18
Pages: 11694-9
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Interaction Experiment
Yang T (2002)
Description: Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
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Protein
Q8BTG6
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein Domain
IPR019352 | SPRING1
Type: Family
Description: SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP [].
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Publication
12202038 | -
First Author: Yang T
Year: 2002
Journal: Cell
Title: Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Volume: 110
Issue: 4
Pages: 489-500
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Strain
MGI:6771136 | C57BL/6JSmoc-Scap<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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HT Experiment
E-MTAB-944 | Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
23299886 | J:205756
 
First Author: Sen S
Year: 2013
Journal: Nat Commun
Title: Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function.
Volume: 4
Pages: 1336
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Publication
36041455 | J:330883
First Author: Kim JY
Year: 2022
Journal: Cell Metab
Title: PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis.
Volume: 34
Issue: 10
Pages: 1548-1560.e6
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Publication
30858281 | J:285677
 
First Author: Su L
Year: 2019
Journal: EMBO J
Title: Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites.
Volume: 38
Issue: 8
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Publication
24217618 | J:208296
First Author: Huber MD
Year: 2013
Journal: J Cell Biol
Title: Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
Volume: 203
Issue: 3
Pages: 427-36
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Publication
26311497 | J:224972
 
First Author: Xu D
Year: 2015
Journal: Nat Commun
Title: PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
Volume: 6
Pages: 8100
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Publication
31039139 | J:308998
   
First Author: Zhang H
Year: 2019
Journal: JCI Insight
Title: Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma.
Volume: 5
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Publication
36577930 | J:353951
First Author: Luo W
Year: 2023
Journal: Nat Immunol
Title: SREBP signaling is essential for effective B cell responses.
Volume: 24
Issue: 2
Pages: 337-348
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Publication
38092754 | J:343423
First Author: Muta Y
Year: 2023
Journal: Nat Commun
Title: Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Volume: 14
Issue: 1
Pages: 8075
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Publication
25498833 | J:292553
First Author: Diao S
Year: 2015
Journal: J Endod
Title: Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced osteogenic differentiation potentials of stem cells from apical papilla.
Volume: 41
Issue: 2
Pages: 205-11
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Publication
29335275 | J:262508
First Author: Linden AG
Year: 2018
Journal: J Lipid Res
Title: Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice.
Volume: 59
Issue: 3
Pages: 475-487
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Publication
39491648 | J:359500
First Author: Uota A
Year: 2024
Journal: J Biol Chem
Title: ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes.
Volume: 300
Issue: 12
Pages: 107953
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Publication
15899885 | J:187576
First Author: Sun LP
Year: 2005
Journal: J Biol Chem
Title: Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.
Volume: 280
Issue: 28
Pages: 26483-90
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Publication
15085196 | J:89213
First Author: Engelking LJ
Year: 2004
Journal: J Clin Invest
Title: Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
Volume: 113
Issue: 8
Pages: 1168-75
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Publication
31267272 | J:289432
First Author: Yang Z
Year: 2019
Journal: Inflammation
Title: Inhibition of the PI3K/AKT Signaling Pathway or Overexpression of Beclin1 Blocks Reinfection of Streptococcus pneumoniae After Infection of Influenza A Virus in Severe Community-Acquired Pneumonia.
Volume: 42
Issue: 5
Pages: 1741-1753
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Publication
33627871 | J:307031
First Author: Lim SA
Year: 2021
Journal: Nature
Title: Lipid signalling enforces functional specialization of Treg cells in tumours.
Volume: 591
Issue: 7849
Pages: 306-311
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Publication
32322062 | J:293711
First Author: Xu D
Year: 2020
Journal: Nature
Title: The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Volume: 580
Issue: 7804
Pages: 530-535
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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