Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1734027 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:3588866 |
Age: |
postnatal day 1 |
|
Note: |
Expression detected in the compact wall of the right and left ventricle. |
Specimen Label: |
4M |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1734220 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 12.5 |
|
Note: |
Strong in ventriculat trabeculations and in prospective right and left bundle branches. |
Specimen Label: |
3H |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1734221 |
Pattern: |
Non-Uniform |
Stage: |
TS21 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 13.5 |
|
Note: |
High in right and left bundle branches and trabeculated ventricular myocardium as compared to ventricular compact myocardium. |
Specimen Label: |
3I, J, K, L, M |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1371864 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7575784 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract. |
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1371864 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280922 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7575784 |
Age: |
embryonic day 14.5 |
|
Note: |
Olfactory bulb (OB) expression was greater than in the ventricular zone. |
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1654615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1654615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract. |
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634515 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634515 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract. |
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635017 |
Pattern: |
Non-Uniform |
Stage: |
TS17 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining remains in all compartments but is higher in ventricular trabeculated myocardium and the prospective right and left bundle branches on either side of the ventricular septum as compared with the nascent interventricular septum. |
Specimen Label: |
3F |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1732127 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3588866 |
Age: |
postnatal day 1 |
|
Note: |
Exprssion in the right and left Atrial appendages. |
Specimen Label: |
4J |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1732127 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3588866 |
Age: |
postnatal day 1 |
|
Note: |
Exprssion in the right and left Atrial appendages. |
Specimen Label: |
4N |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635315 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635315 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract. |
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6457525 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-12-29 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:6488588 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
S1 Table B70 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1731527 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3588866 |
Age: |
postnatal day 1 |
|
Note: |
Exprssion in the right and left Atrial appendages. |
Specimen Label: |
4J |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1731527 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3588866 |
Age: |
postnatal day 1 |
|
Note: |
Exprssion in the right and left Atrial appendages. |
Specimen Label: |
4N |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274819 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
3G |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3588857 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-10-05 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274825 |
Pattern: |
Regionally restricted |
Stage: |
TS25 |
Assay Id: |
MGI:3588866 |
Age: |
embryonic day 17.5 |
|
Note: |
Strong expression was detected in trabecular ventricular myocardium |
Specimen Label: |
4B |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1371864 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-03-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1786922 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7444284 |
Age: |
embryonic day 14.5 |
Image: |
S1C |
Note: |
Expression was detected throughout the valve endothelium. |
Specimen Label: |
S1C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1371864 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-03-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3805122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7444284 |
Age: |
embryonic day 14.5 |
Image: |
S1C |
Note: |
Expression was detected throughout the trabecular endocardium. |
Specimen Label: |
S1C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marionneau C |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels. |
Volume: |
32 |
Issue: |
17 |
Pages: |
5716-27 |
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•
•
•
•
|
Publication |
First Author: |
Chen C |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. |
Volume: |
24 |
Issue: |
16 |
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4030-42 |
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•
•
•
•
|
Publication |
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•
•
•
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Publication |
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Grieco TM |
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2005 |
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Neuron |
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Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. |
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45 |
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2 |
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•
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Publication |
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Biochem Biophys Res Commun |
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A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart. |
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Publication |
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Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. |
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Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Baroni D |
Year: |
2018 |
Journal: |
Hum Mutat |
Title: |
A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel. |
Volume: |
39 |
Issue: |
10 |
Pages: |
1402-1415 |
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DO Term |
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DO Term |
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DO Term |
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Publication |
First Author: |
Nutini M |
Year: |
2011 |
Journal: |
Mol Cell Neurosci |
Title: |
Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse. |
Volume: |
47 |
Issue: |
2 |
Pages: |
108-18 |
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Publication |
First Author: |
Hakim P |
Year: |
2008 |
Journal: |
Prog Biophys Mol Biol |
Title: |
Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties. |
Volume: |
98 |
Issue: |
2-3 |
Pages: |
251-66 |
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Publication |
First Author: |
Hakim P |
Year: |
2010 |
Journal: |
Acta Physiol (Oxf) |
Title: |
Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties. |
Volume: |
198 |
Issue: |
1 |
Pages: |
47-59 |
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Protein Domain |
Type: |
Family |
Description: |
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more non-pore-forming beta subunits. There are five different beta-subunit proteins (beta-1, beta-1B, beta-2, beta-3, and beta-4) encoded by four genes (SCN1B-SCN4B; beta-1B is a splice variant of SCN1B) [, ]. Beta-subunits modulate the kinetics and voltage dependence of the alpha-subunits and they also affect the voltage-gated potassium channels. These subunits participate in nonconducting roles, including cell-cell and cell-matrix adhesion, directing neuronal proliferation, migration, and fasciculation, and modulating the effects of pharmacological compounds on voltage-gated sodium channels, playing important roles in development and disease [, ].Subunit beta-1 is crucial in the assembly, expression, and functional modulation of the sodium channel that can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart [, ]. Both beta-1 and beta-3 associate with neurofascin through their extracellular immunoglobulin-like domains. This association may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons [].This family represents the beta-1 subunit which modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. It plays a critical role in neuronal migration and pathfinding during brain development, and its function is dependent on Na+ current and gamma-secretase activity [, ]. Alterations in this subunit cause epilepsy and cardiac arrhythmia []. Deletion of SCN1B results in Dravet Syndrome, a severe pediatric encephalopathy characterised by epilepsy development [, ]. The D25N mutation in this subunit causes generalised epilepsy with febrile seizure plus type 1 (GEFS+), leading to a maturation (glycosylation) defect of the protein which impairs its targeting to the plasma membrane and interaction with alpha subunits [, ]. |
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Publication |
First Author: |
Oginsky MF |
Year: |
2017 |
Journal: |
J Cell Physiol |
Title: |
Hyperexcitability of Mesencephalic Trigeminal Neurons and Reorganization of Ion Channel Expression in a Rett Syndrome Model. |
Volume: |
232 |
Issue: |
5 |
Pages: |
1151-1164 |
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Publication |
First Author: |
Makita N |
Year: |
1994 |
Journal: |
J Biol Chem |
Title: |
Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene. |
Volume: |
269 |
Issue: |
10 |
Pages: |
7571-8 |
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Publication |
First Author: |
Qin N |
Year: |
2003 |
Journal: |
Eur J Biochem |
Title: |
Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. |
Volume: |
270 |
Issue: |
23 |
Pages: |
4762-70 |
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Publication |
First Author: |
Patino GA |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy. |
Volume: |
31 |
Issue: |
41 |
Pages: |
14577-91 |
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Publication |
First Author: |
Ratcliffe CF |
Year: |
2001 |
Journal: |
J Cell Biol |
Title: |
Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain. |
Volume: |
154 |
Issue: |
2 |
Pages: |
427-34 |
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Publication |
First Author: |
Brackenbury WJ |
Year: |
2011 |
Journal: |
Front Pharmacol |
Title: |
Na Channel β Subunits: Overachievers of the Ion Channel Family. |
Volume: |
2 |
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Pages: |
53 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
218
 |
Fragment?: |
false |
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Publication |
First Author: |
Kaplan DI |
Year: |
2016 |
Journal: |
Cold Spring Harb Perspect Med |
Title: |
Role of Sodium Channels in Epilepsy. |
Volume: |
6 |
Issue: |
6 |
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