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Search results 101 to 180 out of 180 for Scn1b

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0.022s
Type Details Score
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1734027
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3588866
Age: postnatal day 1
Note: Expression detected in the compact wall of the right and left ventricle.
Specimen Label: 4M
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1734220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3588866
Age: embryonic day 12.5
Note: Strong in ventriculat trabeculations and in prospective right and left bundle branches.
Specimen Label: 3H
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1734221
Pattern: Non-Uniform
Stage: TS21
Assay Id: MGI:3588866
Age: embryonic day 13.5
Note: High in right and left bundle branches and trabeculated ventricular myocardium as compared to ventricular compact myocardium.
Specimen Label: 3I, J, K, L, M
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1371864
Assay Type: RNA in situ
Annotation Date: 2024-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7575784
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1634615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3588866
Age: embryonic day 9.5
Note: Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract.
Specimen Label: 3B
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1634615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3588866
Age: embryonic day 9.5
Note: Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract.
Specimen Label: 3D
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1371864
Assay Type: RNA in situ
Annotation Date: 2024-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7575784
Age: embryonic day 14.5
Note: Olfactory bulb (OB) expression was greater than in the ventricular zone.
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3588866
Age: embryonic day 9.5
Note: Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract.
Specimen Label: 3B
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3588866
Age: embryonic day 9.5
Note: Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract.
Specimen Label: 3D
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1634515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3588866
Age: embryonic day 9.5
Note: Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract.
Specimen Label: 3B
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1634515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3588866
Age: embryonic day 9.5
Note: Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract.
Specimen Label: 3D
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1635017
Pattern: Non-Uniform
Stage: TS17
Assay Id: MGI:3588866
Age: embryonic day 10.5
Note: Staining remains in all compartments but is higher in ventricular trabeculated myocardium and the prospective right and left bundle branches on either side of the ventricular septum as compared with the nascent interventricular septum.
Specimen Label: 3F
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1732127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3588866
Age: postnatal day 1
Note: Exprssion in the right and left Atrial appendages.
Specimen Label: 4J
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1732127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3588866
Age: postnatal day 1
Note: Exprssion in the right and left Atrial appendages.
Specimen Label: 4N
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1635315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3588866
Age: embryonic day 9.5
Note: Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract.
Specimen Label: 3B
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1635315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3588866
Age: embryonic day 9.5
Note: Expression was similar in all cardiac compartments, i.e. atrial and ventricular myocardium, and atrioventricular canal and outflow tract.
Specimen Label: 3D
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6457525
Assay Type: RNA in situ
Annotation Date: 2020-12-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757723
Stage: TS23
Assay Id: MGI:6488588
Age: embryonic day 15.5
Specimen Label: S1 Table B70
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1731527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3588866
Age: postnatal day 1
Note: Exprssion in the right and left Atrial appendages.
Specimen Label: 4J
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1731527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3588866
Age: postnatal day 1
Note: Exprssion in the right and left Atrial appendages.
Specimen Label: 4N
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3274819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3588866
Age: embryonic day 11.5
Specimen Label: 3G
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3588857
Assay Type: Immunohistochemistry
Annotation Date: 2005-10-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3274825
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:3588866
Age: embryonic day 17.5
Note: Strong expression was detected in trabecular ventricular myocardium
Specimen Label: 4B
Detected: true
Specimen Num: 8
GXD Expression
Probe: MGI:1371864
Assay Type: RNA in situ
Annotation Date: 2023-03-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1786922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444284
Age: embryonic day 14.5
Image: S1C
Note: Expression was detected throughout the valve endothelium.
Specimen Label: S1C
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:1371864
Assay Type: RNA in situ
Annotation Date: 2023-03-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3805122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444284
Age: embryonic day 14.5
Image: S1C
Note: Expression was detected throughout the trabecular endocardium.
Specimen Label: S1C
Detected: true
Specimen Num: 1
Publication
First Author: Marionneau C
Year: 2012
Journal: J Neurosci
Title: The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.
Volume: 32
Issue: 17
Pages: 5716-27
Publication
First Author: Chen C
Year: 2004
Journal: J Neurosci
Title: Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.
Volume: 24
Issue: 16
Pages: 4030-42
Publication
First Author: Chen C
Year: 2018
Journal: Ann Clin Transl Neurol
Title: Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy.
Volume: 5
Issue: 8
Pages: 982-987
Publication
First Author: Grieco TM
Year: 2005
Journal: Neuron
Title: Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current.
Volume: 45
Issue: 2
Pages: 233-44
Publication
First Author: Tong J
Year: 1993
Journal: Biochem Biophys Res Commun
Title: A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart.
Volume: 195
Issue: 2
Pages: 679-85
Publication
First Author: Haufe V
Year: 2005
Journal: J Physiol
Title: Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.
Volume: 564
Issue: Pt 3
Pages: 683-96
Publication
First Author: Malhotra JD
Year: 2004
Journal: J Biol Chem
Title: Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.
Volume: 279
Issue: 39
Pages: 40748-54
Publication    
First Author: Ogiwara I
Year: 2018
Journal: Commun Biol
Title: Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.
Volume: 1
Publication
First Author: Chinchilla A
Year: 2011
Journal: Circ Cardiovasc Genet
Title: PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.
Volume: 4
Issue: 3
Pages: 269-79
Publication
First Author: de la Rosa AJ
Year: 2013
Journal: Cardiovasc Res
Title: Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.
Volume: 98
Issue: 3
Pages: 504-14
Publication
First Author: Taketo MM
Year: 1997
Journal: Genomics
Title: Mapping of eight testis-specific genes to mouse chromosomes.
Volume: 46
Issue: 1
Pages: 138-42
Publication
First Author: Stubbs L
Year: 1996
Journal: Genomics
Title: Detailed comparative map of human chromosome 19q and related regions of the mouse genome.
Volume: 35
Issue: 3
Pages: 499-508
Publication
First Author: Gu Z
Year: 2015
Journal: PLoS One
Title: Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.
Volume: 10
Issue: 3
Pages: e0121550
Publication
First Author: Harrell MD
Year: 2007
Journal: Physiol Genomics
Title: Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Volume: 28
Issue: 3
Pages: 273-83
Publication  
First Author: Ahuja N
Year: 2022
Journal: Dev Biol
Title: Endothelial Cyp26b1 restrains murine heart valve growth during development.
Volume: 486
Pages: 81-95
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Baroni D
Year: 2018
Journal: Hum Mutat
Title: A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel.
Volume: 39
Issue: 10
Pages: 1402-1415
DO Term
DO Term
DO Term
Publication
First Author: Nutini M
Year: 2011
Journal: Mol Cell Neurosci
Title: Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse.
Volume: 47
Issue: 2
Pages: 108-18
Publication
First Author: Hakim P
Year: 2008
Journal: Prog Biophys Mol Biol
Title: Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties.
Volume: 98
Issue: 2-3
Pages: 251-66
Publication
First Author: Hakim P
Year: 2010
Journal: Acta Physiol (Oxf)
Title: Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties.
Volume: 198
Issue: 1
Pages: 47-59
Protein Domain
Type: Family
Description: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more non-pore-forming beta subunits. There are five different beta-subunit proteins (beta-1, beta-1B, beta-2, beta-3, and beta-4) encoded by four genes (SCN1B-SCN4B; beta-1B is a splice variant of SCN1B) [, ]. Beta-subunits modulate the kinetics and voltage dependence of the alpha-subunits and they also affect the voltage-gated potassium channels. These subunits participate in nonconducting roles, including cell-cell and cell-matrix adhesion, directing neuronal proliferation, migration, and fasciculation, and modulating the effects of pharmacological compounds on voltage-gated sodium channels, playing important roles in development and disease [, ].Subunit beta-1 is crucial in the assembly, expression, and functional modulation of the sodium channel that can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart [, ]. Both beta-1 and beta-3 associate with neurofascin through their extracellular immunoglobulin-like domains. This association may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons [].This family represents the beta-1 subunit which modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. It plays a critical role in neuronal migration and pathfinding during brain development, and its function is dependent on Na+ current and gamma-secretase activity [, ]. Alterations in this subunit cause epilepsy and cardiac arrhythmia []. Deletion of SCN1B results in Dravet Syndrome, a severe pediatric encephalopathy characterised by epilepsy development [, ]. The D25N mutation in this subunit causes generalised epilepsy with febrile seizure plus type 1 (GEFS+), leading to a maturation (glycosylation) defect of the protein which impairs its targeting to the plasma membrane and interaction with alpha subunits [, ].
Publication
First Author: Oginsky MF
Year: 2017
Journal: J Cell Physiol
Title: Hyperexcitability of Mesencephalic Trigeminal Neurons and Reorganization of Ion Channel Expression in a Rett Syndrome Model.
Volume: 232
Issue: 5
Pages: 1151-1164
Publication
First Author: Makita N
Year: 1994
Journal: J Biol Chem
Title: Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene.
Volume: 269
Issue: 10
Pages: 7571-8
Publication
First Author: Qin N
Year: 2003
Journal: Eur J Biochem
Title: Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit.
Volume: 270
Issue: 23
Pages: 4762-70
Publication
First Author: Patino GA
Year: 2011
Journal: J Neurosci
Title: Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy.
Volume: 31
Issue: 41
Pages: 14577-91
Publication
First Author: Ratcliffe CF
Year: 2001
Journal: J Cell Biol
Title: Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain.
Volume: 154
Issue: 2
Pages: 427-34
Publication  
First Author: Brackenbury WJ
Year: 2011
Journal: Front Pharmacol
Title: Na Channel β Subunits: Overachievers of the Ion Channel Family.
Volume: 2
Pages: 53
Protein
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
Publication  
First Author: Kaplan DI
Year: 2016
Journal: Cold Spring Harb Perspect Med
Title: Role of Sodium Channels in Epilepsy.
Volume: 6
Issue: 6