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Search results 101 to 187 out of 187 for Scn2a

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Type Details Score
Publication
18601978 | J:138219
First Author: Vega AV
Year: 2008
Journal: Neurosci Lett
Title: Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.
Volume: 442
Issue: 1
Pages: 69-73
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Publication
16245025 | J:102036
First Author: Bergren SK
Year: 2005
Journal: Mamm Genome
Title: Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a.
Volume: 16
Issue: 9
Pages: 683-90
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Publication
2571571 | J:10031
First Author: Litt M
Year: 1989
Journal: Genomics
Title: Localization of a human brain sodium channel gene (SCN2A) to chromosome 2.
Volume: 5
Issue: 2
Pages: 204-8
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Publication
16033895 | J:99846
First Author: Hossain WA
Year: 2005
Journal: J Neurosci
Title: Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.
Volume: 25
Issue: 29
Pages: 6857-68
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Publication
29991598 | J:265777
First Author: Katz E
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.
Volume: 115
Issue: 30
Pages: E7184-E7192
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Publication
39042440 | J:354919
   
First Author: Masala N
Year: 2024
Journal: Elife
Title: Aberrant hippocampal Ca(2+) microwaves following synapsin-dependent adeno-associated viral expression of Ca(2+) indicators.
Volume: 13
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Publication
8094302 | J:3890
First Author: Pilz AJ
Year: 1993
Journal: Mamm Genome
Title: Dinucleotide repeats in the mouse Hox-4.4 and Hox-4.5 genes on chromosome 2, and their analysis in the BXD and BXH recombinant inbred strains.
Volume: 4
Issue: 2
Pages: 129-30
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Publication
14973256 | J:90115
First Author: Albrieux M
Year: 2004
Journal: J Neurosci
Title: Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.
Volume: 24
Issue: 7
Pages: 1719-25
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Publication
17928448 | J:125694
First Author: Kalume F
Year: 2007
Journal: J Neurosci
Title: Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.
Volume: 27
Issue: 41
Pages: 11065-74
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Publication
8974318 | J:40120
 
First Author: Crabbe JC
Year: 1994
Journal: Alcohol Alcohol Suppl
Title: Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.
Volume: 2
Pages: 67-71
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Publication
17537961 | J:121969
First Author: Ogiwara I
Year: 2007
Journal: J Neurosci
Title: Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.
Volume: 27
Issue: 22
Pages: 5903-14
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Publication
8000136 | J:20127
First Author: Zha H
Year: 1994
Journal: Mamm Genome
Title: A single linkage group comprising 11 polymorphic DNA markers on rat chromosome 3.
Volume: 5
Issue: 9
Pages: 538-41
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Publication
35031483 | J:320523
 
First Author: Heighway J
Year: 2022
Journal: Neurobiol Dis
Title: Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.
Volume: 164
Pages: 105622
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Publication
9806833 | J:51036
First Author: Nakamura T
Year: 1998
Journal: Genomics
Title: Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability.
Volume: 54
Issue: 1
Pages: 89-98
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Publication
17513486 | J:126105
First Author: Figueroa XF
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?
Volume: 293
Issue: 3
Pages: H1371-83
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Publication
8812438 | J:34929
First Author: Beckers MC
Year: 1996
Journal: Genomics
Title: A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.
Volume: 36
Issue: 1
Pages: 202-5
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Publication
17724025 | J:126818
First Author: Zhang MM
Year: 2007
Journal: J Biol Chem
Title: Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.
Volume: 282
Issue: 42
Pages: 30699-706
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Publication
23652591 | J:210871
First Author: Tsunozaki M
Year: 2013
Journal: J Physiol
Title: A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.
Volume: 591
Issue: 13
Pages: 3325-40
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Publication
15746173 | J:109097
First Author: Haufe V
Year: 2005
Journal: J Physiol
Title: Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.
Volume: 564
Issue: Pt 3
Pages: 683-96
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Publication
31691806 | J:328858
First Author: Poeta L
Year: 2019
Journal: Hum Mol Genet
Title: Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.
Volume: 28
Issue: 24
Pages: 4089-4102
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Publication
15907476 | J:98945
First Author: Ballas N
Year: 2005
Journal: Cell
Title: REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.
Volume: 121
Issue: 4
Pages: 645-57
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Publication
15123669 | J:333673
First Author: Fotia AB
Year: 2004
Journal: J Biol Chem
Title: Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.
Volume: 279
Issue: 28
Pages: 28930-5
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Publication
9726281 | J:49707
First Author: Tarantino LM
Year: 1998
Journal: Alcohol Clin Exp Res
Title: Confirmation of quantitative trait loci for alcohol preference in mice.
Volume: 22
Issue: 5
Pages: 1099-105
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Publication
27325115 | J:240247
First Author: Notwell JH
Year: 2016
Journal: Genome Res
Title: TBR1 regulates autism risk genes in the developing neocortex.
Volume: 26
Issue: 8
Pages: 1013-22
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Publication
16723544 | J:109037
First Author: Kim HJ
Year: 2006
Journal: J Neurosci
Title: WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.
Volume: 26
Issue: 21
Pages: 5849-59
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Publication
8169823 | J:18566
First Author: Crabbe JC
Year: 1994
Journal: J Pharmacol Exp Ther
Title: Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.
Volume: 269
Issue: 1
Pages: 184-92
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Publication
21339379 | J:187349
First Author: Hu XL
Year: 2011
Journal: Cereb Cortex
Title: Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model.
Volume: 21
Issue: 9
Pages: 2158-65
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Publication
37321992 | J:340358
First Author: Oh H
Year: 2023
Journal: Nat Commun
Title: Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
Volume: 14
Issue: 1
Pages: 3547
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Publication
8268655 | J:15206
First Author: Kondo Y
Year: 1993
Journal: Mamm Genome
Title: DNA segments mapped by reciprocal use of microsatellite primers between mouse and rat.
Volume: 4
Issue: 10
Pages: 571-6
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
37876801 | J:342024
First Author: Li M
Year: 2023
Journal: iScience
Title: Scn2a insufficiency alters spontaneous neuronal Ca(2+) activity in somatosensory cortex during wakefulness.
Volume: 26
Issue: 11
Pages: 108138
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Publication
11166117 | J:108884
First Author: Kearney JA
Year: 2001
Journal: Neuroscience
Title: A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities.
Volume: 102
Issue: 2
Pages: 307-17
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Allele
Scn2a<tm2(SCN2A)Cya> | MGI:7657322
Name: sodium channel, voltage-gated, type II, alpha; targeted mutation 2, Cyagen Biosciences
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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DO Term
DOID:0060965 | episodic ataxia type 9
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Strain
MGI:7657662 | C57BL/6N-Scn2a<tm2(SCN2A)Cya>/Cya
Attribute String: coisogenic, targeted mutation, mutant strain
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Publication
28137877 | J:240934
First Author: Thompson CH
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice.
Volume: 114
Issue: 7
Pages: 1696-1701
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DO Term
DOID:0080421 | developmental and epileptic encephalopathy 11
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DO Term
DOID:0081116 | benign familial infantile seizures 3
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Publication
30605671 | J:288338
First Author: Gunther EC
Year: 2019
Journal: Cell Rep
Title: Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.
Volume: 26
Issue: 1
Pages: 145-158.e8
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Publication
11756608 | -
First Author: Abou-Khalil B
Year: 2001
Journal: Neurology
Title: Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation.
Volume: 57
Issue: 12
Pages: 2265-72
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Protein Domain
IPR008051 | Na_channel_a1su
Type: Family
Description: Voltage-dependent sodium channels are transmembrane (TM) proteins responsible for the depolarising phase of the action potential in mostelectrically excitable cells []. They may exist in 3 states []: the resting state, where the channel is closed; the activated state, where the channel is open; and the inactivated state, where the channel is closed and refractory to opening. Several different structurally and functionally distinct isoforms are found in mammals, coded for by a multigene family, these being responsible for the different types of sodium ion currents found in excitable tissues.There are nine pore-forming alpha subunit of voltage-gated sodium channels consisting of four membrane-embedded homologous domains (I-IV), each consisting of six α-helical segments (S1-S6), three cytoplasmic loops connecting the domains, and a cytoplasmic C-terminal tail. The S6 segments of the four domains form the inner surface of the pore, while the S4 segments bear clusters of basic residues that constitute the channel's voltage sensors [, , ].The SCN1A gene encodes the NaB1 channel and is particularly expressed inthe brain, but is also found in a variety of other tissues, ranging from theretina to the olfactory bulb. Epilepsy, a disorder of neuronalhyperexcitability, has been associated with altered kinetics of SCN1A, aswell as delayed inactivation of SCN2A [].This entry represents the alpha 1 subunits of the voltage-gated Na+ channel superfamily. For entries containing other members of this superfamily see , , .
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Publication
17881658 | J:129998
First Author: Martin MS
Year: 2007
Journal: Hum Mol Genet
Title: The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.
Volume: 16
Issue: 23
Pages: 2892-9
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Publication
24704313 | J:213648
 
First Author: Makinson CD
Year: 2014
Journal: Neurobiol Dis
Title: Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.
Volume: 68
Pages: 16-25
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Publication
11259483 | J:136430
First Author: Rosenmann H
Year: 2001
Journal: J Neurochem
Title: Prion protein with an E200K mutation displays properties similar to those of the cellular isoform PrP(C).
Volume: 76
Issue: 6
Pages: 1654-62
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Publication
27112236 | J:232547
First Author: Calhoun JD
Year: 2016
Journal: Epilepsia
Title: Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2a.
Volume: 57
Issue: 6
Pages: e103-7
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Publication
19513789 | J:150721
First Author: Bergren SK
Year: 2009
Journal: Mamm Genome
Title: Fine mapping of an epilepsy modifier gene on mouse Chromosome 19.
Volume: 20
Issue: 6
Pages: 359-66
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Publication
22471526 | J:198033
First Author: Hawkins NA
Year: 2012
Journal: Genes Brain Behav
Title: Confirmation of an epilepsy modifier locus on mouse chromosome 11 and candidate gene analysis by RNA-Seq.
Volume: 11
Issue: 4
Pages: 452-60
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Publication
37219072 | J:340870
   
First Author: Yamagata T
Year: 2023
Journal: Elife
Title: Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons.
Volume: 12
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Publication
8095862 | J:15988
First Author: Pfeifer K
Year: 1993
Journal: Cell Biochem Funct
Title: Kinetics of expression of prion protein in uninfected and scrapie-infected N2a mouse neuroblastoma cells.
Volume: 11
Issue: 1
Pages: 1-11
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Publication
17697940 | J:124982
First Author: Watt NT
Year: 2007
Journal: Free Radic Biol Med
Title: Cellular prion protein protects against reactive-oxygen-species-induced DNA damage.
Volume: 43
Issue: 6
Pages: 959-67
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Publication
1338978 | J:136436
First Author: Scott MR
Year: 1992
Journal: Protein Sci
Title: Chimeric prion protein expression in cultured cells and transgenic mice.
Volume: 1
Issue: 8
Pages: 986-97
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Publication
23849776 | J:206687
First Author: Jiang YH
Year: 2013
Journal: Am J Hum Genet
Title: Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing.
Volume: 93
Issue: 2
Pages: 249-63
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Publication
26553874 | J:228573
First Author: Bate C
Year: 2016
Journal: J Biol Chem
Title: Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.
Volume: 291
Issue: 1
Pages: 160-70
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Publication
29046322 | J:248369
First Author: Follwaczny P
Year: 2017
Journal: Dis Model Mech
Title: Pumilio2-deficient mice show a predisposition for epilepsy.
Volume: 10
Issue: 11
Pages: 1333-1342
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Publication
24657915 | J:212131
 
First Author: Oliva MK
Year: 2014
Journal: Neurobiol Dis
Title: Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy.
Volume: 67
Pages: 180-90
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Protein
A2APX9
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: true
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Protein
A2APX8
Organism: Mus musculus/domesticus
Length: 2009  
Fragment?: false
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Publication
6209577 | -
First Author: Noda M
Year: 1984
Journal: Nature
Title: Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.
Volume: 312
Issue: 5990
Pages: 121-7
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Publication
1317577 | -
First Author: George AL Jr
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.
Volume: 89
Issue: 11
Pages: 4893-7
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Publication
21947499 | -
First Author: Goldfarb M
Year: 2012
Journal: Cell Mol Life Sci
Title: Voltage-gated sodium channel-associated proteins and alternative mechanisms of inactivation and block.
Volume: 69
Issue: 7
Pages: 1067-76
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Publication
27143702 | -
 
First Author: Kaplan DI
Year: 2016
Journal: Cold Spring Harb Perspect Med
Title: Role of Sodium Channels in Epilepsy.
Volume: 6
Issue: 6
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Publication
1323284 | -
First Author: Sato C
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Proposed tertiary structure of the sodium channel.
Volume: 186
Issue: 2
Pages: 1158-67
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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