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Search results 101 to 124 out of 124 for Sec62

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0.017s

Type

Details

Score

Allele

Sec62<Gt(W038C03)Wrst> | MGI:4336766

Name:	SEC62 homolog, preprotein translocation; gene trap W038C03, German Gene Trap Consortium
Allele Type:	Gene trapped

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Allele

Sec62<Gt(IST14317B11)Tigm> | MGI:5223439

Name:	SEC62 homolog, preprotein translocation; gene trap IST14317B11, Texas A&M Institute for Genomic Medicine
Allele Type:	Gene trapped

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Strain

MGI:6188017 | C57BL/6NJ-Sec62<em1(IMPC)J>/Mmjax

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

Genotype

Symbol:	Sec62/Sec62
Background:	C57BL/6NJ-Sec62/Mmjax
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Sec62/Sec62<+>
Background:	C57BL/6NJ-Sec62/Mmjax
Zygosity:	ht
Has Mutant Allele:	true

•

Protein Domain

IPR011553 | Sec62_asco

Type:

Family

Description:

Members of the NSCC2 family have been sequenced from various fungal and animal species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.This family of Sec62 proteins is restricted to the Ascomycota.

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Publication

11226176 | -

First Author:	Young BP
Year:	2001
Journal:	EMBO J
Title:	Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.
Volume:	20
Issue:	1-2
Pages:	262-71

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Publication

10543453 | -

First Author:	Skowronek MH
Year:	1999
Journal:	Biol Chem
Title:	Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog.
Volume:	380
Issue:	9
Pages:	1133-8

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Publication

15133510 | -

First Author:	Davila S
Year:	2004
Journal:	Nat Genet
Title:	Mutations in SEC63 cause autosomal dominant polycystic liver disease.
Volume:	36
Issue:	6
Pages:	575-7

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Protein Domain

IPR027137 | Sec63

Type:

Family

Description:

In Saccharomyces cerevisiae, Sec63 is a component of the Sec62/63 complex (includes Sec63p, Sec62p, Sec66p and Sec72p), which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex []. In humans, Sec63 is part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63. It is required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane [, ].Defects in SEC63 are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterised by the presence of multiple liver cysts of biliary epithelial origin [].

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Publication

17208939 | -

First Author:	Lee J
Year:	2007
Journal:	Mol Cell Proteomics
Title:	Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.
Volume:	6
Issue:	4
Pages:	669-76

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Protein

Q8K2U5

Organism:	Mus musculus/domesticus
Length:	516
Fragment?:	true

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Protein

Q8VHE0

Organism:	Mus musculus/domesticus
Length:	760
Fragment?:	false

•

Protein

Q80YG4

Organism:	Mus musculus/domesticus
Length:	760
Fragment?:	false

•

Publication

18630941 | -

First Author:	Zhou H
Year:	2008
Journal:	J Proteome Res
Title:	Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
Volume:	7
Issue:	9
Pages:	3957-67

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Publication

19144319 | J:143718

First Author:	Trost M
Year:	2009
Journal:	Immunity
Title:	The phagosomal proteome in interferon-gamma-activated macrophages.
Volume:	30
Issue:	1
Pages:	143-54

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Publication

17242355 | -

First Author:	Villén J
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	Large-scale phosphorylation analysis of mouse liver.
Volume:	104
Issue:	5
Pages:	1488-93

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Publication

11042159 | J:68323

First Author:	Carninci P
Year:	2000
Journal:	Genome Res
Title:	Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume:	10
Issue:	10
Pages:	1617-30

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Publication

10349636 | J:80645

First Author:	Carninci P
Year:	1999
Journal:	Methods Enzymol
Title:	High-efficiency full-length cDNA cloning.
Volume:	303

Pages:	19-44

•

Publication

11076861 | J:68324

First Author:	Shibata K
Year:	2000
Journal:	Genome Res
Title:	RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume:	10
Issue:	11
Pages:	1757-71

•

Publication

16141073 | -

First Author:	Katayama S
Year:	2005
Journal:	Science
Title:	Antisense transcription in the mammalian transcriptome.
Volume:	309
Issue:	5740
Pages:	1564-6

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Publication

16141072 | J:99680

First Author:	Carninci P
Year:	2005
Journal:	Science
Title:	The transcriptional landscape of the mammalian genome.
Volume:	309
Issue:	5740
Pages:	1559-63

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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