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Search results 101 to 163 out of 163 for Sec63

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Type Details Score
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Gene
107973494 | LOC107973494
Type: gene
Organism: chimpanzee
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Protein
F6XQ35
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: true
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Publication
11023840 | -
 
First Author: Ponting CP
Year: 2000
Journal: Biochem J
Title: Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction.
Volume: 351 Pt 2
Pages: 527-35
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Publication
16368690 | -
First Author: Jermy AJ
Year: 2006
Journal: J Biol Chem
Title: The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.
Volume: 281
Issue: 12
Pages: 7899-906
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Protein Domain
IPR004179 | Sec63-dom
Type: Domain
Description: This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl domain) protein in which it was found. This protein is required for assembly of functional endoplasmic reticulum translocons [, ]. Other yeast proteins containing this domain include pre-mRNA splicing helicase BRR2, HFM1 protein and putative helicases.
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UniProt Feature
UniProt Feature
Begin: 1
Description: Translocation protein SEC63 homolog
Type: chain
End: 760
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Publication
21251912 | J:169113
First Author: Müller L
Year: 2011
Journal: FEBS Lett
Title: An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease.
Volume: 585
Issue: 4
Pages: 596-600
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Gene
443902 | sec63.S
Type: gene
Organism: frog, African clawed
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Gene
495416 | sec63.L
Type: gene
Organism: frog, African clawed
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Allele
Sec63<+> | MGI:2441225
   
Name: SEC63 homolog, protein translocation regulator; wild type
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Allele
Sec63<Gt(CSG271)Byg> | MGI:3877897
 
Name: SEC63 homolog, protein translocation regulator; gene trap CSG271, BayGenomics
Allele Type: Gene trapped
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Allele
Sec63<Gt(OST362830)Lex> | MGI:4294769
 
Name: SEC63 homolog, protein translocation regulator; gene trap OST362830, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sec63<tm1Som> | MGI:5442171
Name: SEC63 homolog, protein translocation regulator; targeted mutation 1, Stefan Somlo
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Sec63<tm1.1Som> | MGI:5442304
Name: SEC63 homolog, protein translocation regulator; targeted mutation 1.1, Stefan Somlo
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
8257794 | -
First Author: Kurihara T
Year: 1993
Journal: Mol Biol Cell
Title: Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.
Volume: 4
Issue: 9
Pages: 919-30
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Allele
Sec63<Gt(IST14886E2)Tigm> | MGI:5268221
 
Name: SEC63 homolog, protein translocation regulator; gene trap IST14886E2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sec63<tm1a(EUCOMM)Hmgu> | MGI:5318757
Name: SEC63 homolog, protein translocation regulator; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Sec63<tm1e(EUCOMM)Hmgu> | MGI:5318739
Name: SEC63 homolog, protein translocation regulator; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Sec63<tm1b(EUCOMM)Hmgu> | MGI:5692793
Name: SEC63 homolog, protein translocation regulator; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Sec63<em1Gpt> | MGI:7305871
Name: SEC63 homolog, protein translocation regulator; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Sec63<em2Gpt> | MGI:7305872
Name: SEC63 homolog, protein translocation regulator; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Sec63/Sec63
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein
Q7TMG2
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: true
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Publication
12518317 | -
First Author: Willer M
Year: 2003
Journal: Yeast
Title: Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane.
Volume: 20
Issue: 2
Pages: 133-48
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Strain
MGI:6143380 | C57BL/6N-Sec63<tm1a(EUCOMM)Hmgu>/BayMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6260449 | C57BL/6N-Sec63<tm1b(EUCOMM)Hmgu>/Bay
Attribute String: coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Sec63/Sec63 Tg(CAG-cre/Esr1*)1Lbe/?
Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sec63/Sec63 Tg(Cdh16-cre)91Igr/?
Background: involves: 129 * C57BL/6 * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sec63/Sec63
Background: C57BL/6N-Sec63/Bay
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:3036246 | Hfm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
D3Z4R1
Organism: Mus musculus/domesticus
Length: 1434  
Fragment?: false
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DO Term
DOID:0060975 | polycystic liver disease 2
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Genotype
Genotype
Symbol: Sec63/Sec63 Tg(Pkd1)248Som/? Tg(Cdh16-cre)91Igr/?
Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sec63/Sec63<+>
Background: C57BL/6N-Sec63/Bay
Zygosity: ht
Has Mutant Allele: true
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Protein
E9PZJ8
Organism: Mus musculus/domesticus
Length: 2198  
Fragment?: false
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Protein
Q6P4T2
Organism: Mus musculus/domesticus
Length: 2136  
Fragment?: false
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Genotype
Genotype
Symbol: Prkcsh/Prkcsh Sec63/Sec63 Tg(Cdh16-cre)91Igr/?
Background: involves: 129 * C57BL/6 * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1<+> Sec63/Sec63 Tg(Cdh16-cre)91Igr/?
Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd2/Pkd2<+> Sec63/Sec63 Tg(Cdh16-cre)91Igr/?
Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
29154852 | J:272325
 
First Author: Hirose M
Year: 2018
Journal: Mitochondrion
Title: The mitochondrial uncoupling protein 2 gene is causal for the spontaneous polycystic liver diseases in mice.
Volume: 42
Pages: 50-53
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Protein
Q8BU14
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q9CRY0
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
Q05DA2
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
Q8CIK3
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: true
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Protein Domain
IPR004728 | Sec62
Type: Family
Description: Members of the NSCC2 family have been sequenced from various yeast, fungal and animals species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.
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Protein Domain
IPR011553 | Sec62_asco
Type: Family
Description: Members of the NSCC2 family have been sequenced from various fungal and animal species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.This family of Sec62 proteins is restricted to the Ascomycota.
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Publication
33512716 | J:316971
First Author: Xu WP
Year: 2021
Journal: J Pathol
Title: Deletion of Sox9 in the liver leads to hepatic cystogenesis in mice by transcriptionally downregulating Sec63.
Volume: 254
Issue: 1
Pages: 57-69
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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