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Search results 101 to 170 out of 170 for Sesn1

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Type Details Score
Publication
20203043 | J:233574
First Author: Lee JH
Year: 2010
Journal: Science
Title: Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
Volume: 327
Issue: 5970
Pages: 1223-8
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Publication
35771919 | J:326737
First Author: Cangelosi AL
Year: 2022
Journal: Science
Title: Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
Volume: 377
Issue: 6601
Pages: 47-56
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Publication
32197071 | J:287183
First Author: Li Z
Year: 2020
Journal: Cell Metab
Title: Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism.
Volume: 31
Issue: 4
Pages: 741-754.e5
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Publication
11695551 | J:73022
 
First Author: Venkatachalam S
Year: 2001
Journal: Toxicol Pathol
Title: Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing.
Volume: 29 Suppl
Pages: 147-54
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Publication
25259925 | J:214946
First Author: Peng M
Year: 2014
Journal: Cell
Title: Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
Volume: 159
Issue: 1
Pages: 122-133
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Publication
31929512 | J:285905
First Author: Kim M
Year: 2020
Journal: Nat Commun
Title: Sestrins are evolutionarily conserved mediators of exercise benefits.
Volume: 11
Issue: 1
Pages: 190
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Publication
22958918 | J:189021
First Author: Lee JH
Year: 2012
Journal: Cell Metab
Title: Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Volume: 16
Issue: 3
Pages: 311-21
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Publication
18692468 | J:139563
First Author: Budanov AV
Year: 2008
Journal: Cell
Title: p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Volume: 134
Issue: 3
Pages: 451-60
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Publication
31929511 | J:286680
First Author: Segalés J
Year: 2020
Journal: Nat Commun
Title: Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.
Volume: 11
Issue: 1
Pages: 189
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Publication
11707774 | J:72844
First Author: Chalhoub N
Year: 2001
Journal: Mamm Genome
Title: Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21.
Volume: 12
Issue: 12
Pages: 887-92
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Publication
27694478 | J:268403
First Author: Zhou L
Year: 2017
Journal: FASEB J
Title: Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
Volume: 31
Issue: 1
Pages: 132-147
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Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Sesn1<tm1.2Moli> | MGI:6414891
Name: sestrin 1; targeted mutation 1.2 Ming Li
Allele Type: Targeted
Attribute String: Null/knockout
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Protein
Q8CAN4
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
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Protein
A0A140LIE1
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Publication
7938006 | -
First Author: Buckbinder L
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.
Volume: 91
Issue: 22
Pages: 10640-4
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Publication
12203114 | -
First Author: Budanov AV
Year: 2002
Journal: Oncogene
Title: Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.
Volume: 21
Issue: 39
Pages: 6017-31
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Protein Domain
IPR006730 | Sestrin
Type: Family
Description: Sestrins (Sesns) are involved in ROS (reactive oxygen species) regulation. In mammals, there are three Sestrins (Sesn1, Sesn2, and Sesn3), while in Drosophila melanogaster and C. elegans, there is only one Sesn []. The N-terminal of Sesns shares protein sequence and structural similarity with the C-terminal α-helical domain of the AhpD protein from Mycobacterium tuberculosis. Interestingly, AhpD is a component of alkyl-hydroperoxide reductase participating in defense against ROS and ROS produced by host immune cells []. Sesn1 (also known as p53-activated gene 26, PA26) was first identified as a target of the p53 protein through a screen []. Subsequently, Sesn2 (also known as hypoxia-inducible gene 95, Hi95) was identified by microarray-based analysis of novel genes activated by prolonged hypoxia []. Both the Sesn1 and Sesn2 genes can be activated by genotoxic stress in a p53-dependent manner []. All three mammalian Sesns can be activated by the transcription factor forkhead transcription factor (FoxO3A) and FoxO1, members of the FoxO gene family [].
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Publication
23274085 | J:195093
First Author: Bae SH
Year: 2013
Journal: Cell Metab
Title: Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Volume: 17
Issue: 1
Pages: 73-84
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Protein
Q9CYP7
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
P58006
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
P58043
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q3TCT3
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q3TDF4
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
A0A0J9YMZ5
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
V5QRJ1
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
E9PXR3
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
V5QQD1
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
A2RSF4
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
20712410 | -
First Author: Budanov AV
Year: 2011
Journal: Antioxid Redox Signal
Title: Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling.
Volume: 15
Issue: 6
Pages: 1679-90
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Publication
11799204 | -
First Author: Bryk R
Year: 2002
Journal: Science
Title: Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
Volume: 295
Issue: 5557
Pages: 1073-7
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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