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Search results 101 to 173 out of 173 for Sesn2

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Type Details Score
Publication
24005285 | J:201646
First Author: Forsberg K
Year: 2013
Journal: J Neurosci
Title: The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
Volume: 33
Issue: 36
Pages: 14318-30
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Publication
27454290 | J:237115
First Author: Deng W
Year: 2016
Journal: J Clin Invest
Title: p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing.
Volume: 126
Issue: 8
Pages: 2941-54
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Publication
25366347 | J:218267
First Author: Morrison A
Year: 2015
Journal: FASEB J
Title: Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.
Volume: 29
Issue: 2
Pages: 408-17
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Publication
18692468 | J:139563
First Author: Budanov AV
Year: 2008
Journal: Cell
Title: p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Volume: 134
Issue: 3
Pages: 451-60
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Publication
31915252 | J:285299
First Author: Kowalsky AH
Year: 2020
Journal: J Biol Chem
Title: The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
Volume: 295
Issue: 7
Pages: 1769-1780
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Publication
36154620 | J:335524
First Author: Zhu S
Year: 2022
Journal: Circulation
Title: Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy.
Volume: 146
Issue: 13
Pages: 1028-1031
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Publication
17032746 | J:116620
First Author: Petri A
Year: 2006
Journal: J Mol Endocrinol
Title: The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice.
Volume: 37
Issue: 2
Pages: 301-16
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Publication
19273598 | J:148991
First Author: Barkić M
Year: 2009
Journal: Mol Cell Biol
Title: The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival.
Volume: 29
Issue: 10
Pages: 2489-504
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Publication
31749402 | J:283328
First Author: Klimovich B
Year: 2020
Journal: Cell Cycle
Title: Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo.
Volume: 19
Issue: 1
Pages: 109-123
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Publication
36127134 | J:345447
First Author: Dong C
Year: 2022
Journal: J Neurosci
Title: Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.
Volume: 42
Issue: 44
Pages: 8373-8392
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Publication
19805316 | J:153232
First Author: Meechan DW
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.
Volume: 106
Issue: 38
Pages: 16434-45
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Publication
36539111 | J:333714
 
First Author: Huynh H
Year: 2023
Journal: J Mol Cell Cardiol
Title: DELE1 is protective for mitochondrial cardiomyopathy.
Volume: 175
Pages: 44-48
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Publication
34048907 | J:307395
 
First Author: Mirra S
Year: 2021
Journal: Neurobiol Dis
Title: CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina.
Volume: 156
Pages: 105405
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Publication
34242585 | J:308686
First Author: Tiu GC
Year: 2021
Journal: Dev Cell
Title: A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.
Volume: 56
Issue: 14
Pages: 2089-2102.e11
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Publication
38588611 | J:347601
 
First Author: Shen T
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice.
Volume: 710
Pages: 149883
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Publication
22173065 | J:180791
First Author: Saravanamuthu SS
Year: 2012
Journal: Dev Biol
Title: Conditional ablation of the Notch2 receptor in the ocular lens.
Volume: 362
Issue: 2
Pages: 219-29
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Publication
39747033 | J:360776
First Author: Di Michele M
Year: 2025
Journal: Nat Commun
Title: E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development.
Volume: 16
Issue: 1
Pages: 67
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Publication
26745185 | J:229930
 
First Author: Nechiporuk T
Year: 2016
Journal: Elife
Title: The REST remodeling complex protects genomic integrity during embryonic neurogenesis.
Volume: 5
Pages: e09584
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Publication
22560297 | J:184521
First Author: Koss M
Year: 2012
Journal: Dev Cell
Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Volume: 22
Issue: 5
Pages: 913-26
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q8CAN4
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
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Protein
A0A140LIE1
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Publication
7938006 | -
First Author: Buckbinder L
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.
Volume: 91
Issue: 22
Pages: 10640-4
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Publication
12203114 | -
First Author: Budanov AV
Year: 2002
Journal: Oncogene
Title: Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.
Volume: 21
Issue: 39
Pages: 6017-31
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Protein Domain
IPR006730 | Sestrin
Type: Family
Description: Sestrins (Sesns) are involved in ROS (reactive oxygen species) regulation. In mammals, there are three Sestrins (Sesn1, Sesn2, and Sesn3), while in Drosophila melanogaster and C. elegans, there is only one Sesn []. The N-terminal of Sesns shares protein sequence and structural similarity with the C-terminal α-helical domain of the AhpD protein from Mycobacterium tuberculosis. Interestingly, AhpD is a component of alkyl-hydroperoxide reductase participating in defense against ROS and ROS produced by host immune cells []. Sesn1 (also known as p53-activated gene 26, PA26) was first identified as a target of the p53 protein through a screen []. Subsequently, Sesn2 (also known as hypoxia-inducible gene 95, Hi95) was identified by microarray-based analysis of novel genes activated by prolonged hypoxia []. Both the Sesn1 and Sesn2 genes can be activated by genotoxic stress in a p53-dependent manner []. All three mammalian Sesns can be activated by the transcription factor forkhead transcription factor (FoxO3A) and FoxO1, members of the FoxO gene family [].
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Protein
Q9CYP7
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
P58006
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
P58043
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q3TCT3
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q497S6
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
Q3TDF4
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
A0A0J9YMZ5
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
V5QRJ1
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
E9PXR3
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
V5QQD1
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
A2RSF4
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
20712410 | -
First Author: Budanov AV
Year: 2011
Journal: Antioxid Redox Signal
Title: Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling.
Volume: 15
Issue: 6
Pages: 1679-90
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Publication
11799204 | -
First Author: Bryk R
Year: 2002
Journal: Science
Title: Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
Volume: 295
Issue: 5557
Pages: 1073-7
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Publication
30048751 | J:270617
First Author: Wang T
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Volume: 1864
Issue: 10
Pages: 3368-3377
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Publication
35316214 | J:326463
 
First Author: Kouzu H
Year: 2022
Journal: J Clin Invest
Title: ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice.
Volume: 132
Issue: 10
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Publication
35452917 | J:338347
 
First Author: Wang A J
Year: 2022
Journal: Redox Biol
Title: Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Volume: 52
Pages: 102310
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Publication
32071292 | J:287892
First Author: Wang LX
Year: 2020
Journal: Cell Death Dis
Title: Sestrin2 protects dendritic cells against endoplasmic reticulum stress-related apoptosis induced by high mobility group box-1 protein.
Volume: 11
Issue: 2
Pages: 125
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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