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Search results 101 to 174 out of 174 for Sf3b4

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0.014s
Type Details Score
GXD Expression    
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:3587889
Age: embryonic day 7.5-8.0
Image: 4B
Specimen Label: 4B
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Ubiquitous
Stage: TS13
Assay Id: MGI:6431571
Age: embryonic day 8.5
Image: 2B E8.5
Note: Expression in whole body including neuroepithelium.
Specimen Label: 2B E8.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Pattern: Ubiquitous
Stage: TS15
Assay Id: MGI:6431571
Age: embryonic day 9.5
Image: 2B E9.5
Note: Expression in whole body including neuroepithelium.
Specimen Label: 2B E9.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Ubiquitous
Stage: TS17
Assay Id: MGI:6431571
Age: embryonic day 10.5
Image: 2B E10.5
Note: Expression in whole body including neuroepithelium.
Specimen Label: 2B E10.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1640815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6431571
Age: embryonic day 9.5
Image: 2B E9.5
Specimen Label: 2B E9.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1640817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6431571
Age: embryonic day 10.5
Image: 2B E10.5
Specimen Label: 2B E10.5
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185817
Pattern: Ubiquitous
Stage: TS17
Assay Id: MGI:6431571
Age: embryonic day 10.5
Image: 2D
Note: Ubiquitous expression in cranial area including the brain.
Specimen Label: 2D
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Pattern: Ubiquitous
Stage: TS20
Assay Id: MGI:6431571
Age: embryonic day 12.5
Image: 2E
Note: Ubiquitous expression in cranial regions.
Specimen Label: 2E
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607313
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:6431571
Age: embryonic day 8.5
Image: 2B E8.5
Specimen Label: 2B E8.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6431571
Age: embryonic day 9.5
Image: 2B E9.5
Specimen Label: 2B E9.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1718520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6431571
Age: embryonic day 12.5
Image: 2E
Specimen Label: 2E
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1664016
Stage: TS16
Assay Id: MGI:3587889
Age: embryonic day 10.0
Image: 4C
Specimen Label: 4C
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1664016
Stage: TS16
Assay Id: MGI:3587889
Age: embryonic day 10.0
Image: 4D
Specimen Label: 4D
Detected: false
Specimen Num: 3
GXD Expression  
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1659515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6431571
Age: embryonic day 9.5
Image: 2B E9.5
Specimen Label: 2B E9.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1612917
Pattern: Ubiquitous
Stage: TS17
Assay Id: MGI:6431571
Age: embryonic day 10.5
Image: 2G
Note: Ubiquitous expression in neural crest cells and non-Dlx5-expressing mesodermal cells.
Specimen Label: 2G
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1646917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6431571
Age: embryonic day 10.5
Image: 2B E10.5
Specimen Label: 2B E10.5
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2513323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6431571
Age: embryonic day 15.5
Image: 2F
Note: Relatively higher expression in masticatory muscles
Specimen Label: 2F
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3615961
Assay Type: RNA in situ
Annotation Date: 2006-03-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1679727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617444
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
GXD Expression  
Probe: MGI:3615961
Assay Type: RNA in situ
Annotation Date: 2006-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617444
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615961
Assay Type: RNA in situ
Annotation Date: 2006-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617444
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615961
Assay Type: RNA in situ
Annotation Date: 2006-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617444
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3267923
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6431571
Age: embryonic day 15.5
Image: 2I
Specimen Label: 2I
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3587889
Age: embryonic day 14.0
Image: 4H fourth
Specimen Label: 4H fourth
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:3615961
Assay Type: RNA in situ
Annotation Date: 2006-03-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617444
Age: embryonic day 13.5
Image: E13.5
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: E13.5
Specimen Num: 1
GXD Expression  
Probe: MGI:3615961
Assay Type: RNA in situ
Annotation Date: 2006-03-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1757727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617444
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1618418
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3587889
Age: embryonic day 11.0
Image: 4E
Specimen Label: 4E
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1618416
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:3587889
Age: embryonic day 10.0
Image: 4C
Specimen Label: 4C
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1618416
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:3587889
Age: embryonic day 10.0
Image: 4D
Specimen Label: 4D
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1618418
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3587889
Age: embryonic day 11.0
Image: 4F
Specimen Label: 4F
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:6431551
Assay Type: RNA in situ
Annotation Date: 2020-06-04
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6431571
Age: embryonic day 15.5
Image: 2I
Note: Intense expression in brain particularly in the ventricular zone.
Specimen Label: 2I
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3587889
Age: embryonic day 11.5
Image: 4H first
Specimen Label: 4H first
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3587889
Age: embryonic day 12.5
Image: 4H second
Specimen Label: 4H second
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3587889
Age: embryonic day 13.5
Image: 4H third
Specimen Label: 4H third
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:707852
Assay Type: RNA in situ
Annotation Date: 2005-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3587889
Age: embryonic day 14.0
Image: 4H fourth
Specimen Label: 4H fourth
Detected: true
Specimen Num: 10
Publication
First Author: Ruiz-Lozano P
Year: 1997
Journal: Dev Dyn
Title: Developmental expression of the murine spliceosome-associated protein mSAP49.
Volume: 208
Issue: 4
Pages: 482-90
Publication
First Author: Zheng S
Year: 2013
Journal: Genome Res
Title: A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.
Volume: 23
Issue: 6
Pages: 998-1007
Publication
First Author: Isono K
Year: 2005
Journal: Genes Dev
Title: Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.
Volume: 19
Issue: 5
Pages: 536-41
Publication  
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Petit F
Year: 2014
Journal: Clin Genet
Title: Nager syndrome: confirmation of SF3B4 haploinsufficiency as the major cause.
Volume: 86
Issue: 3
Pages: 246-51
DO Term
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of SF3B4, also termed pre-mRNA-splicing factor SF3b 49kDa (SF3b50), or spliceosome-associated protein 49 (SAP 49). SF3B4 is a component of the multiprotein complex splicing factor 3b (SF3B), an integral part of the U2 small nuclear ribonucleoprotein (snRNP) and the U11/U12 di-snRNP. SF3B is essential for the accurate excision of introns from pre-messenger RNA, and is involved in the recognition of the pre-mRNA's branch site within the major and minor spliceosomes []. SF3B4 functions to tether U2 snRNP with pre-mRNA at the branch site during spliceosome assembly []. It is an evolutionarily highly conserved protein with orthologues across diverse species.SF3B4 contains two closely adjacent N-terminal RNA recognition motifs (RRMs). It binds directly to pre-mRNA and also interacts directly and highly specifically with another SF3B subunit called SAP 145 [].Mutations in the SF3B4 gene cause Nager syndrome, a form of acrofacial dysostosis which affects the development of the face, hands, and arms [].
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of SF3B4, also termed pre-mRNA-splicing factor SF3b 49kDa (SF3b50), or spliceosome-associated protein 49 (SAP 49). SF3B4 is a component of the multiprotein complex splicing factor 3b (SF3B), an integral part of the U2 small nuclear ribonucleoprotein (snRNP) and the U11/U12 di-snRNP. SF3B is essential for the accurate excision of introns from pre-messenger RNA, and is involved in the recognition of the pre-mRNA's branch site within the major and minor spliceosomes []. SF3B4 functions to tether U2 snRNP with pre-mRNA at the branch site during spliceosome assembly []. It is an evolutionarily highly conserved protein with orthologues across diverse species.SF3B4 contains two closely adjacent N-terminal RNA recognition motifs (RRMs). It binds directly to pre-mRNA and also interacts directly and highly specifically with another SF3B subunit called SAP 145 [].Mutations in the SF3B4 gene cause Nager syndrome, a form of acrofacial dysostosis which affects the development of the face, hands, and arms [].
Publication
First Author: Champion-Arnaud P
Year: 1994
Journal: Genes Dev
Title: The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site.
Volume: 8
Issue: 16
Pages: 1974-83
Publication
First Author: Golas MM
Year: 2003
Journal: Science
Title: Molecular architecture of the multiprotein splicing factor SF3b.
Volume: 300
Issue: 5621
Pages: 980-4
Protein
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
Publication
First Author: Kumar S
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Etiology of craniofacial and cardiac malformations in a mouse model of SF3B4-related syndromes.
Volume: 121
Issue: 39
Pages: e2405523121