Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2851823 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12763 |
|
Specimen Label: |
GUDMAP:12763 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2851823 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12764 |
|
Specimen Label: |
GUDMAP:12764 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754021 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:3508505 |
Age: |
embryonic day 13.5 |
Image: |
1 |
Note: |
Expression was detected in some cells. |
Specimen Label: |
1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754027 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3508505 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2760523 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6504 |
|
Specimen Label: |
GUDMAP:6504 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2760523 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12763 |
|
Specimen Label: |
GUDMAP:12763 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2760523 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12764 |
|
Specimen Label: |
GUDMAP:12764 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280927 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3508505 |
Age: |
postnatal newborn |
Image: |
2 |
Note: |
The tissue was olfactory epithelium and/or bulb. |
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2776227 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:5540018 |
Age: |
postnatal day 0 |
Image: |
GUDMAP:7236 |
|
Specimen Label: |
GUDMAP:7236 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267921 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3508505 |
Age: |
embryonic day 13.5 |
Image: |
1 |
|
Specimen Label: |
1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267927 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3508505 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6504 |
|
Specimen Label: |
GUDMAP:6504 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2852723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12763 |
|
Specimen Label: |
GUDMAP:12763 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2852723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12764 |
|
Specimen Label: |
GUDMAP:12764 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2874723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6504 |
|
Specimen Label: |
GUDMAP:6504 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2874723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12763 |
|
Specimen Label: |
GUDMAP:12763 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:3508505 |
Age: |
embryonic day 13.5 |
Image: |
1 |
Note: |
Expression was detected in some cells. |
Specimen Label: |
1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3508505 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6504 |
|
Specimen Label: |
GUDMAP:6504 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12763 |
|
Specimen Label: |
GUDMAP:12763 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12764 |
|
Specimen Label: |
GUDMAP:12764 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6504 |
|
Specimen Label: |
GUDMAP:6504 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3507061 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5540018 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12763 |
|
Specimen Label: |
GUDMAP:12763 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
836
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
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West RJH |
Year: |
2018 |
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Hum Mol Genet |
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The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia. |
Volume: |
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Issue: |
8 |
Pages: |
1382-1395 |
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•
•
•
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Publication |
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Year: |
2022 |
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POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function. |
Volume: |
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Publication |
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Year: |
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Journal: |
Front Neurosci |
Title: |
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. |
Volume: |
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Pages: |
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Publication |
First Author: |
The Jackson Laboratory |
Year: |
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Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
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Publication |
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The Gene Ontology Consortium |
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Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
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GUDMAP Consortium |
Year: |
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Journal: |
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Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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Year: |
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Database Release |
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Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
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MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Scientific Curators |
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Title: |
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Allen Institute for Brain Science |
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Mouse Genome Informatics Scientific Curators |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
892
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
828
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
862
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
381
 |
Fragment?: |
false |
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•
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•
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UniProt Feature |
Begin: |
1 |
Description: |
E3 ubiquitin-protein ligase SH3RF1 |
Type: |
chain |
End: |
892 |
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•
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Publication |
First Author: |
Kukekov NV |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. |
Volume: |
281 |
Issue: |
22 |
Pages: |
15517-24 |
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•
•
•
•
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Publication |
First Author: |
Xu Z |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. |
Volume: |
22 |
Issue: |
2 |
Pages: |
252-61 |
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•
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Publication |
First Author: |
Tuvia S |
Year: |
2007 |
Journal: |
J Cell Biol |
Title: |
The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp. |
Volume: |
177 |
Issue: |
1 |
Pages: |
51-61 |
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Protein Domain |
Type: |
Domain |
Description: |
SH3RF1 (or POSH) and SH3RF3 (or POSH2) are scaffold proteins that function as E3 ubiquitin-protein ligases. They contain an N-terminal RING finger domain and four SH3 domains []. This entry represents the fourth SH3 domain, located at the C terminus of SH3RF1 and SH3RF3, and similar domains. SH3RF1 plays a role in calcium homeostasis through the control of the ubiquitin domain protein Herp []. It may also have a role in regulating death receptor mediated and JNK mediated apoptosis []. SH3RF3 interacts with p21-activated kinase 2 (PAK2) and GTP-loaded Rac1 []. |
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Protein Domain |
Type: |
Family |
Description: |
SH3RF1 (or POSH) is a scaffold protein that function as an E3 ubiquitin-protein ligase. It contains an N-terminal RING finger domain and four SH3 domains. It belongs to the POSH family, which includes POSH1, POSH2 and POSH3 []. |
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•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
SH3RF2 is also called POSHER (POSH-eliminating RING protein) or HEPP1 (heart protein phosphatase 1-binding protein). It acts as an anti-apoptotic regulator of the JNK pathway by binding to and promoting the degradation of SH3RF1 (or POSH), a scaffold protein that is required for pro-apoptotic JNK activation []. It may also play a role in cardiac functions together with protein phosphatase 1 []. SH3RF2 contains an N-terminal RING finger domain and three SH3 domains. |
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•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
SH3RF2 is also called POSHER (POSH-eliminating RING protein) or HEPP1 (heart protein phosphatase 1-binding protein). It acts as an anti-apoptotic regulator of the JNK pathway by binding to and promoting the degradation of SH3RF1 (or POSH), a scaffold protein that is required for pro-apoptotic JNK activation []. It may also play a role in cardiac functions together with protein phosphatase 1 []. SH3RF2 contains an N-terminal RING finger domain and three SH3 domains. This entry represents the second SH3 domain of SH3RF2. |
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Publication |
First Author: |
Wilhelm M |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. |
Volume: |
287 |
Issue: |
3 |
Pages: |
2247-56 |
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•
•
•
•
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Publication |
First Author: |
Chen CY |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). |
Volume: |
391 |
Issue: |
1 |
Pages: |
698-702 |
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•
•
•
•
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Publication |
First Author: |
Kärkkäinen S |
Year: |
2010 |
Journal: |
FEBS Lett |
Title: |
POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. |
Volume: |
584 |
Issue: |
18 |
Pages: |
3867-72 |
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•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
SH3RF2 is also called POSHER (POSH-eliminating RING protein) or HEPP1 (heart protein phosphatase 1-binding protein). It acts as an anti-apoptotic regulator of the JNK pathway by binding to and promoting the degradation of SH3RF1 (or POSH), a scaffold protein that is required for pro-apoptotic JNK activation []. It may also play a role in cardiac functions together with protein phosphatase 1 []. SH3RF2 contains an N-terminal RING finger domain and three SH3 domains. This entry represents the first SH3 domain, located at the N-terminal half, of SH3RF2. |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
878
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
735
 |
Fragment?: |
false |
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•
•
•
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Publication |
First Author: |
Okazaki N |
Year: |
2004 |
Journal: |
DNA Res |
Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
Volume: |
11 |
Issue: |
3 |
Pages: |
205-18 |
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•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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•
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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