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Search results 101 to 200 out of 201 for Siah2

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760620
Stage: TS20
Assay Id: MGI:5013449
Age: embryonic day 12.5
Image: 6F/G
Specimen Label: 6F/G
Detected: false
Specimen Num: 4
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•
GXD Expression
GXD Expression
 
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5013449
Age: embryonic day 14.5
Image: 6J/K
Specimen Label: 6J/K
Detected: true
Specimen Num: 5
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•
GXD Expression
GXD Expression
 
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5013449
Age: embryonic day 16.5
Image: 6N/O
Specimen Label: 6N/O
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1760628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5013449
Age: postnatal week 2
Image: 6R/S
Specimen Label: 6R/S
Detected: true
Specimen Num: 7
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•
GXD Expression
GXD Expression
   
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Specimen Label: Not shown
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5013449
Age: postnatal week 2
Specimen Label: Not shown
Detected: true
Specimen Num: 8
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4844492
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848433
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Absent
Sex: Male
Emaps: EMAPS:3148228
Stage: TS28
Assay Id: MGI:3813363
Age: postnatal adult
Specimen Label: 3I
Detected: false
Specimen Num: 16
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Absent
Sex: Male
Emaps: EMAPS:3148228
Stage: TS28
Assay Id: MGI:3813363
Age: postnatal adult
Specimen Label: 3G,H
Detected: false
Specimen Num: 15
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716825
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Image: 5A-C,E,F,H,I
Specimen Label: 5A-C,E,F,H,I
Detected: true
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5013449
Age: postnatal week 2
Specimen Label: Not shown
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274025
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Image: 5A-C,E,F,H,I
Note: Expression is in areas of proliferating cartilage.
Specimen Label: 5A-C,E,F,H,I
Detected: true
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760725
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Image: 5A-C,E,F,H,I
Specimen Label: 5A-C,E,F,H,I
Detected: false
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4844492
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1653615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848433
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:3066766
Assay Type: RNA in situ
Annotation Date: 2011-10-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Pattern: Widespread
Stage: TS12
Assay Id: MGI:5291815
Age: embryonic day 8.0
Image: E8.0
Specimen Label: E8.0
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3813363
Age: postnatal adult
Specimen Label: 3E
Detected: true
Specimen Num: 14
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3813363
Age: postnatal adult
Specimen Label: 3G,H
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3813363
Age: postnatal adult
Specimen Label: 3I
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859225
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Image: 5A-C,E,F,H,I
Note: Expression is in the ganglion cell layer.
Specimen Label: 5A-C,E,F,H,I
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160403
Stage: TS03
Assay Id: MGI:3813363
Age: embryonic day 2.5
Specimen Label: 2D,E
Detected: false
Specimen Num: 11
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•
•
GXD Expression
GXD Expression
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1919625
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Image: 5A-C,E,F,H,I
Note: Expression is in areas of proliferating cartilage.
Specimen Label: 5A-C,E,F,H,I
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Absent
Sex: Male
Emaps: EMAPS:1797225
Stage: TS25
Assay Id: MGI:3813363
Age: embryonic day 17.5
Specimen Label: Not shown
Detected: false
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3813363
Age: postnatal day 6
Specimen Label: 3B
Detected: false
Specimen Num: 13
•
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273025
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Image: 5A-C,E,F,H,I
Note: Expression is in cells of proliferating cartilage but not in hypertrophied chondrocytes.
Specimen Label: 5A-C,E,F,H,I
Detected: true
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:3813363
Age: embryonic day 1.0
Specimen Label: 2A,B
Detected: true
Specimen Num: 10
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Specimen Label: Not shown
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768025
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5013449
Age: embryonic day 17.5
Image: 5A-C,E,F,H,I
Note: Expression is in areas of proliferating cartilage at the base of the skull.
Specimen Label: 5A-C,E,F,H,I
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4844492
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1654315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848433
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5013448
Assay Type: RNA in situ
Annotation Date: 2011-07-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654317
Stage: TS17
Assay Id: MGI:5013449
Age: embryonic day 10.5
Image: 6B/C
Specimen Label: 6B/C
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4844492
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1638815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848433
Age: embryonic day 9.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Absent
Sex: Male
Emaps: EMAPS:3148828
Stage: TS28
Assay Id: MGI:3813363
Age: postnatal adult
Specimen Label: 3I
Detected: false
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3813355
Assay Type: RNA in situ
Annotation Date: 2008-10-30
Strength: Absent
Sex: Male
Emaps: EMAPS:3148828
Stage: TS28
Assay Id: MGI:3813363
Age: postnatal adult
Specimen Label: 3G,H
Detected: false
Specimen Num: 15
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Publication
17003045 | -
First Author: Khurana A
Year: 2006
Journal: J Biol Chem
Title: Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.
Volume: 281
Issue: 46
Pages: 35316-26
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Publication
29892230 | J:277433
 
First Author: Schiattarella GG
Year: 2018
Journal: Front Physiol
Title: Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure.
Volume: 9
Pages: 558
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Publication
24061476 | J:206089
First Author: Lindner JM
Year: 2013
Journal: Mol Cell Biol
Title: A C-terminal acidic domain regulates degradation of the transcriptional coactivator Bob1.
Volume: 33
Issue: 23
Pages: 4628-40
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Publication
37078793 | J:336555
First Author: Scortegagna M
Year: 2023
Journal: Cancer Res
Title: Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.
Volume: 83
Issue: 12
Pages: 2016-2033
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Publication
11884614 | J:75489
First Author: Dickins RA
Year: 2002
Journal: Mol Cell Biol
Title: The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.
Volume: 22
Issue: 7
Pages: 2294-303
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Publication
21109632 | J:166970
First Author: Famulski JK
Year: 2010
Journal: Science
Title: Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.
Volume: 330
Issue: 6012
Pages: 1834-8
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Publication
20609350 | J:161781
First Author: Qi J
Year: 2010
Journal: Cancer Cell
Title: Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.
Volume: 18
Issue: 1
Pages: 23-38
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Publication
31825833 | J:297790
First Author: Suhail A
Year: 2019
Journal: Cell Rep
Title: DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
Volume: 29
Issue: 11
Pages: 3522-3538.e7
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Publication
9143490 | J:39837
First Author: Holloway AJ
Year: 1997
Journal: Genomics
Title: Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.
Volume: 41
Issue: 2
Pages: 160-8
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Publication
27178982 | J:234018
   
First Author: Singh S
Year: 2016
Journal: Elife
Title: Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.
Volume: 5
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Publication
22008794 | J:143778
First Author: Tamplin OJ
Year: 2011
Journal: Dev Biol
Title: Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Volume: 360
Issue: 2
Pages: 415-25
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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•
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase SIAH2
Type: chain
End: 325
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Publication
19372575 | J:205250
First Author: Nakayama K
Year: 2009
Journal: Mol Cancer Res
Title: The ubiquitin ligase Siah2 and the hypoxia response.
Volume: 7
Issue: 4
Pages: 443-51
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Interaction Experiment
Kilroy G (2012)
Description: The ubiquitin ligase Siah2 regulates PPAR activity in adipocytes.
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Publication
14645235 | -
First Author: Fanelli M
Year: 2004
Journal: J Biol Chem
Title: The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.
Volume: 279
Issue: 7
Pages: 5374-9
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Publication
9637679 | -
First Author: Zhang J
Year: 1998
Journal: Genes Dev
Title: Proteasomal regulation of nuclear receptor corepressor-mediated repression.
Volume: 12
Issue: 12
Pages: 1775-80
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Publication
10681424 | -
First Author: Relaix F
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.
Volume: 97
Issue: 5
Pages: 2105-10
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Publication
11257006 | -
First Author: Sourisseau T
Year: 2001
Journal: J Cell Sci
Title: Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis.
Volume: 114
Issue: Pt 7
Pages: 1409-16
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Protein Domain
IPR037305 | TRAF2_MATH
Type: Domain
Description: TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis [, ].TRAF2 is heavily regulated by ubiquitin signals. It has E3 ubiquitin-protein ligase activity and promotes K63-linked ubiquitination of target proteins. Alternatively, TRAF2 may be required for recruiting other E3 ligases, such as A20, to help processing and turnover. Furthermore, TRAF2 is regulated by both K63 and K48 type ubiquitin chains. K63 linkage may be mediated by TRAF2 auto-ubiquitination, and is required for TRAF2 activation. c-IAPl and Siah2 are known E3 ligases that can K48-ubiquitinate TRAF2 to target it for proteasome-dependent degradation [, , ]. TRAF2 contains a RING finger domain, five zinc finger domains, and a TRAF domain. The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [, ].
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Protein Domain
IPR027133 | TRAF2
Type: Family
Description: TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis [, ].TRAF2 is heavily regulated by ubiquitin signals. It has E3 ubiquitin-protein ligase activity and promotes K63-linked ubiquitination of target proteins. Alternatively, TRAF2 may be required for recruiting other E3 ligases, such as A20, to help processing and turnover. Furthermore, TRAF2 is regulated by both K63 and K48 type ubiquitin chains. K63 linkage may be mediated by TRAF2 auto-ubiquitination, and is required for TRAF2 activation. c-IAPl and Siah2 are known E3 ligases that can K48-ubiquitinate TRAF2 to target it for proteasome-dependent degradation [, , ]. TRAF2 contains a RING finger domain, five zinc finger domains, and a TRAF domain.
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Publication
10346818 | -
First Author: Baud V
Year: 1999
Journal: Genes Dev
Title: Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Volume: 13
Issue: 10
Pages: 1297-308
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Publication
18981220 | -
First Author: Blackwell K
Year: 2009
Journal: Mol Cell Biol
Title: TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.
Volume: 29
Issue: 2
Pages: 303-14
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Publication
20577214 | J:162639
First Author: Alvarez SE
Year: 2010
Journal: Nature
Title: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Volume: 465
Issue: 7301
Pages: 1084-8
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Publication
28230156 | J:244409
 
First Author: Trivedi N
Year: 2017
Journal: Nat Commun
Title: Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection.
Volume: 8
Pages: 14484
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Publication
17633015 | -
 
First Author: Au PY
Year: 2007
Journal: Adv Exp Med Biol
Title: Physiological roles and mechanisms of signaling by TRAF2 and TRAF5.
Volume: 597
Pages: 32-47
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Publication
15258597 | -
First Author: Wertz IE
Year: 2004
Journal: Nature
Title: De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
Volume: 430
Issue: 7000
Pages: 694-9
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Publication
31515251 | J:282181
First Author: Park CS
Year: 2019
Journal: Blood
Title: A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells.
Volume: 134
Issue: 22
Pages: 1960-1972
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Publication
11483518 | J:204647
First Author: Boehm J
Year: 2001
Journal: EMBO J
Title: Regulation of BOB.1/OBF.1 stability by SIAH.
Volume: 20
Issue: 15
Pages: 4153-62
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Publication
23038274 | J:196800
First Author: Krämer OH
Year: 2013
Journal: Leukemia
Title: SIAH proteins: critical roles in leukemogenesis.
Volume: 27
Issue: 4
Pages: 792-802
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Publication
10518213 | J:57751
First Author: Ye H
Year: 1999
Journal: Mol Cell
Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.
Volume: 4
Issue: 3
Pages: 321-30
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Protein
P39429
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q3U8L1
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q8C6X9
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q8CAQ7
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q3TWR1
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Publication
10206649 | -
First Author: Park YC
Year: 1999
Journal: Nature
Title: Structural basis for self-association and receptor recognition of human TRAF2.
Volume: 398
Issue: 6727
Pages: 533-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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