Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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UniProt Feature |
Begin: |
1 |
Description: |
Serine/threonine-protein kinase SIK3 |
Type: |
chain |
End: |
1369 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1369
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1214
 |
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
487
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
506
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
71
 |
Fragment?: |
true |
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•
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•
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Publication |
First Author: |
Csukasi F |
Year: |
2018 |
Journal: |
Sci Transl Med |
Title: |
The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling. |
Volume: |
10 |
Issue: |
459 |
|
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•
•
•
•
•
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Publication |
First Author: |
Jaitovich A |
Year: |
2010 |
Journal: |
Biochim Biophys Acta |
Title: |
Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure. |
Volume: |
1802 |
Issue: |
12 |
Pages: |
1140-9 |
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Publication |
First Author: |
Takemori H |
Year: |
2003 |
Journal: |
J Steroid Biochem Mol Biol |
Title: |
Salt-inducible kinase-mediated regulation of steroidogenesis at the early stage of ACTH-stimulation. |
Volume: |
85 |
Issue: |
2-5 |
Pages: |
397-400 |
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•
•
•
•
•
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Publication |
First Author: |
Ahmed AA |
Year: |
2010 |
Journal: |
Cancer Cell |
Title: |
SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer. |
Volume: |
18 |
Issue: |
2 |
Pages: |
109-21 |
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•
•
•
•
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Publication |
First Author: |
Katoh Y |
Year: |
2004 |
Journal: |
Mol Cell Endocrinol |
Title: |
Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis. |
Volume: |
217 |
Issue: |
1-2 |
Pages: |
109-12 |
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•
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•
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Publication |
First Author: |
Hietakangas V |
Year: |
2008 |
Journal: |
Cell Metab |
Title: |
TORCing up metabolic control in the brain. |
Volume: |
7 |
Issue: |
5 |
Pages: |
357-8 |
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•
•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
SIKs are serine/threonine kinasse that are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure []. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells []. In the brain, both SIK1 and SIK2 regulate energy metabolism []. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1 []. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism []. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein []. |
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Publication |
First Author: |
Jeppesen J |
Year: |
2013 |
Journal: |
Diabetes |
Title: |
LKB1 regulates lipid oxidation during exercise independently of AMPK. |
Volume: |
62 |
Issue: |
5 |
Pages: |
1490-9 |
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•
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•
•
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Publication |
First Author: |
Kim MK |
Year: |
2019 |
Journal: |
Cell Death Dis |
Title: |
Salt-inducible kinase 1 regulates bone anabolism via the CRTC1-CREB-Id1 axis. |
Volume: |
10 |
Issue: |
11 |
Pages: |
826 |
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•
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•
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Publication |
First Author: |
Park M |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need. |
Volume: |
10 |
Issue: |
1 |
Pages: |
8676 |
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•
•
•
•
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Publication |
First Author: |
Nishimori S |
Year: |
2021 |
Journal: |
Bone |
Title: |
PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. |
Volume: |
142 |
|
Pages: |
115709 |
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•
•
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•
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Publication |
First Author: |
van Gijsel-Bonnello M |
Year: |
2022 |
Journal: |
J Biol Chem |
Title: |
Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury. |
Volume: |
298 |
Issue: |
12 |
Pages: |
102644 |
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•
•
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•
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Publication |
First Author: |
Houde VP |
Year: |
2014 |
Journal: |
Biochem J |
Title: |
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. |
Volume: |
458 |
Issue: |
1 |
Pages: |
41-56 |
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Publication |
First Author: |
Lombardi MS |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis. |
Volume: |
12 |
Issue: |
10 |
Pages: |
e0185426 |
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•
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Publication |
First Author: |
Wang G |
Year: |
2022 |
Journal: |
J Neurosci |
Title: |
Somatic genetics analysis of sleep in adult mice. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1319
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
779
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
931
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
929
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
931
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
927
 |
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Guo A |
Year: |
2014 |
Journal: |
Mol Cell Proteomics |
Title: |
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. |
Volume: |
13 |
Issue: |
1 |
Pages: |
372-87 |
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•
•
•
•
•
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Publication |
First Author: |
Villén J |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Large-scale phosphorylation analysis of mouse liver. |
Volume: |
104 |
Issue: |
5 |
Pages: |
1488-93 |
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•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
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