Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1716828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3585958 |
Age: |
postnatal adult |
Image: |
Adult |
|
Specimen Label: |
Adult |
Detected: |
false |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585958 |
Age: |
postnatal day 6-7 |
|
|
Specimen Label: |
P6/7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585958 |
Age: |
postnatal day 8-10 |
Image: |
P8/10 |
|
Specimen Label: |
P8/10 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1647028 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3585958 |
Age: |
postnatal day 6 |
|
|
Specimen Label: |
CNS |
Detected: |
false |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603924 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:3585958 |
Age: |
embryonic day 16.0 |
|
Note: |
Expression was widespread. |
Specimen Label: |
Embryo |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915726 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:3585958 |
Age: |
embryonic day 18.0 |
|
Note: |
Expression was detected in the vitreal outer neuroblastic layer. |
Specimen Label: |
E18 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3585958 |
Age: |
postnatal day 0-1 |
Image: |
P0/1 |
Note: |
Expression was detected in the outer neuroblastic layer. |
Specimen Label: |
P0/1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3585958 |
Age: |
postnatal day 2-3 |
Image: |
P2/3 |
Note: |
Expression was detected in the outer neuroblastic layer. |
Specimen Label: |
P2/3 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585958 |
Age: |
postnatal day 6-7 |
|
|
Specimen Label: |
P6/7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585958 |
Age: |
postnatal day 8-10 |
Image: |
P8/10 |
|
Specimen Label: |
P8/10 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859224 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:3585958 |
Age: |
embryonic day 16.0 |
Image: |
E16 |
Note: |
Expression was detected in the vitreal outer neuroblastic layer. |
Specimen Label: |
E16 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4947536 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-04-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:4947545 |
Age: |
embryonic day 3.5 |
|
Note: |
There is general expression in all cells. |
Specimen Label: |
3A blastocyst |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4947536 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-04-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160403 |
Pattern: |
Not Specified |
Stage: |
TS03 |
Assay Id: |
MGI:4947545 |
Age: |
embryonic day 3.0 |
|
Note: |
There is general expression in all cells. |
Specimen Label: |
3A morula |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kotake Y |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. |
Volume: |
280 |
Issue: |
2 |
Pages: |
1095-102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhong L |
Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. |
Volume: |
117 |
Issue: |
10 |
Pages: |
2869-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Umanskaya K |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor. |
Volume: |
27 |
Issue: |
21 |
Pages: |
7615-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maddika S |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. |
Volume: |
29 |
Issue: |
5 |
Pages: |
1235-48 |
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•
•
•
•
•
|
Publication |
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Zhao B |
Year: |
2019 |
Journal: |
Nat Immunol |
Title: |
Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12. |
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10 |
Pages: |
1381-1392 |
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•
•
•
•
|
Publication |
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Piva R |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation. |
Volume: |
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23 |
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8375-87 |
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•
•
•
•
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Publication |
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Journal: |
Proc Natl Acad Sci U S A |
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7 |
Pages: |
3859-63 |
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•
•
•
•
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Publication |
First Author: |
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Year: |
2001 |
Journal: |
Genomics |
Title: |
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3 |
Pages: |
214-22 |
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•
•
•
•
|
Publication |
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Year: |
2006 |
Journal: |
Am J Respir Cell Mol Biol |
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The role of metallothionein in the pathogenesis of acute lung injury. |
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1 |
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73-82 |
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•
•
•
•
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Publication |
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EMBO J |
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pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. |
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6 |
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844-57 |
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•
•
•
•
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Publication |
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Li M |
Year: |
2008 |
Journal: |
Nat Cell Biol |
Title: |
The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. |
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9 |
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1083-9 |
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•
•
•
•
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Publication |
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2013 |
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Proc Natl Acad Sci U S A |
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Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. |
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978-83 |
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•
•
•
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Publication |
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Mol Cell Biol |
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Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination. |
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8951-62 |
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•
•
•
•
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PLoS One |
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Nature |
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BMC Dev Biol |
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Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3. |
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Mol Cell Biol |
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A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. |
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Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Inuzuka H |
Year: |
2012 |
Journal: |
Cell |
Title: |
Acetylation-dependent regulation of Skp2 function. |
Volume: |
150 |
Issue: |
1 |
Pages: |
179-93 |
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•
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Publication |
First Author: |
Shim EH |
Year: |
2003 |
Journal: |
Cancer Res |
Title: |
Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. |
Volume: |
63 |
Issue: |
7 |
Pages: |
1583-8 |
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•
•
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•
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Publication |
First Author: |
Cai Z |
Year: |
2020 |
Journal: |
Semin Cancer Biol |
Title: |
The Skp2 Pathway: A Critical Target for Cancer Therapy. |
Volume: |
67 |
Issue: |
Pt 2 |
Pages: |
16-33 |
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•
•
•
•
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Publication |
First Author: |
Xu XL |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells. |
Volume: |
77 |
Issue: |
24 |
Pages: |
6838-6850 |
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•
•
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Publication |
First Author: |
Wang J |
Year: |
2021 |
Journal: |
Ann N Y Acad Sci |
Title: |
The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma. |
Volume: |
1490 |
Issue: |
1 |
Pages: |
90-104 |
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•
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Publication |
First Author: |
Song P |
Year: |
2011 |
Journal: |
Circ Res |
Title: |
AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells. |
Volume: |
109 |
Issue: |
11 |
Pages: |
1230-9 |
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•
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•
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Publication |
First Author: |
Chen J |
Year: |
2021 |
Journal: |
Oncogene |
Title: |
EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation. |
Volume: |
40 |
Issue: |
1 |
Pages: |
163-176 |
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•
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•
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Publication |
First Author: |
Sicari BM |
Year: |
2012 |
Journal: |
Endocrinology |
Title: |
c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein. |
Volume: |
153 |
Issue: |
2 |
Pages: |
861-72 |
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•
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Interaction Experiment |
Description: |
Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2. |
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Publication |
First Author: |
Hu L |
Year: |
2009 |
Journal: |
Cancer Res |
Title: |
Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222. |
Volume: |
69 |
Issue: |
8 |
Pages: |
3374-81 |
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GO Term |
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Allele |
Name: |
S-phase kinase-associated protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Publication |
First Author: |
Wang GZ |
Year: |
2020 |
Journal: |
bioRxiv |
Title: |
Degradation of SARS-CoV-2 receptor ACE2 by tobacco carcinogen-induced Skp2 in lung epithelial cells Running title: ACE2 catabolism in lung epithelial cells. |
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Interaction Experiment |
Description: |
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. |
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Publication |
First Author: |
Michel JJ |
Year: |
1998 |
Journal: |
Cell Growth Differ |
Title: |
Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. |
Volume: |
9 |
Issue: |
6 |
Pages: |
435-49 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
424
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
131
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
354
 |
Fragment?: |
false |
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Allele |
Name: |
transgene insertion 4, Michele Pagano |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
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Allele |
Name: |
transgene insertion 31, Hui Zhang |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
•
•
•
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Allele |
Name: |
transgene insertion 33, Hui Zhang |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
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•
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Genotype |
Symbol: |
Tg(SKP2)4Paga/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
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Allele |
Name: |
transgene insertion 79, Hui Zhang |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
•
•
•
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Publication |
First Author: |
Ilyin GP |
Year: |
2000 |
Journal: |
Genomics |
Title: |
cDNA cloning and expression analysis of new members of the mammalian F-box protein family. |
Volume: |
67 |
Issue: |
1 |
Pages: |
40-7 |
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•
•
•
•
•
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Publication |
First Author: |
Yu WN |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. |
Volume: |
12 |
Issue: |
4 |
Pages: |
610-21 |
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