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Search results 101 to 121 out of 121 for Smarcal1

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Type Details Score
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
E-GEOD-35553 | Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression (3)
Series Id: GSE35553
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
22995303 | -
First Author: Zhang L
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Targeting SMARCAL1 as a novel strategy for cancer therapy.
Volume: 427
Issue: 2
Pages: 232-5
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Publication
22279047 | -
First Author: Bétous R
Year: 2012
Journal: Genes Dev
Title: SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication.
Volume: 26
Issue: 2
Pages: 151-62
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Allele
Smarcal1<em1Smoc> | MGI:7292474
Name: SNF2 related chromatin remodeling ATPase like 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6476339 | C57BL/6JSmoc-Smarcal1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Smarcal1<tm1.1Cfbo> | MGI:5425295
Name: SNF2 related chromatin remodeling ATPase like 1; targeted mutation 1.1, Cornelius F Boerkoel
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Smarcal1/Smarcal1
Background: either: B6.129-Smarcal1 or (involves: 129 * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060490 | Schimke immuno-osseous dysplasia
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Protein
D3YUX5
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: true
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Publication
21525954 | -
First Author: Ghosal G
Year: 2011
Journal: EMBO Rep
Title: The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1.
Volume: 12
Issue: 6
Pages: 574-80
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Protein Domain
IPR010003 | HARP_dom
Type: Domain
Description: SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator ofchromatin, subfamily A-like1), also known as DNA-dependent ATPase A and HARP(Hep-A-related proteins), maintains genome integrity during DNA replication.SMARCAL1 has ATP-dependent annealing helicase activity, which helps tostabilise stalled replication forks and facilitate DNA repair duringreplication. Biochemically, SMARCAL1 can bind to DNA that contains single- anddouble-stranded regions such as forks and DNA hairpins. DNA binding activatesits ATPase activity, and this activity promotes DNA single-stranded annealing[, ].SMARCAL1 is a multifunctional protein. The ATPase domain, which lies in the C-terminal half of the protein, is split into two regions of primary amino acidsequence by a 115-amino-acid linker sequence. The N-terminalhalf of the protein contains a highly sequence conserved ssDNA-binding proteinreplication protein A (RPA)-binding domain, and one or two HARP domain(s). Theevolutionarily conserved HARP domain determines the annealing helicaseactivity required for the in vivo and in vitro functions of SMARCAL1 [, , ].
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Publication
18974355 | -
First Author: Yusufzai T
Year: 2008
Journal: Science
Title: HARP is an ATP-driven annealing helicase.
Volume: 322
Issue: 5902
Pages: 748-50
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Protein Domain
IPR030101 | HARP(SMARCAL1)
Type: Family
Description: HARP (HepA-related protein; also known as SMARCAL1 and DNA-dependent ATPase A) is an ATP-driven annealing helicase that acts throughout the genome to re-anneal stably unwound DNA []. It helps to stabilise stalled replication forks and facilitate DNA repair during replication [, ]. SMARCAL1 binds directly to forked DNA structures or can be recruited to replication forks via interaction with the single-stranded DNA binding protein RPA []. Mutations in the HARP gene are responsible for a pleiotropic disorder known as Schimke immuno-osseous dysplasia (SIOD) [].
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Protein
Q8BJL0
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
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