| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3274122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287422 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1624622 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
| Note: |
Expression was strong in the digestive system. |
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1721422 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1646922 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1736222 |
| Pattern: |
Scattered |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1683322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1700022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1832122 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-07-18 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7666072 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
| Note: |
Expression was strong in the immune system. |
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1741222 |
| Pattern: |
Scattered |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3599822 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280922 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1833322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1821522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3557722 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1702122 |
| Pattern: |
Scattered |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1668822 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757722 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
| Image: |
MH1539; Specimen C1540 |
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1738322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1802422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the skull (base and vault). |
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724933 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2672022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421584 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in whisker follicle. |
| Specimen Label: |
MH1539; Specimen C1540 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Levade T |
| Year: |
1999 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Signalling sphingomyelinases: which, where, how and why? |
| Volume: |
1438 |
| Issue: |
1 |
| Pages: |
1-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu Z |
| Year: |
2022 |
| Journal: |
Mol Neurobiol |
| Title: |
Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts. |
| Volume: |
59 |
| Issue: |
5 |
| Pages: |
3233-3253 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhong L |
| Year: |
2018 |
| Journal: |
J Lipid Res |
| Title: |
Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice. |
| Volume: |
59 |
| Issue: |
5 |
| Pages: |
795-804 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Clarke CJ |
| Year: |
2006 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Neutral sphingomyelinases and nSMase2: bridging the gaps. |
| Volume: |
1758 |
| Issue: |
12 |
| Pages: |
1893-901 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Philipp S |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. |
| Volume: |
107 |
| Issue: |
3 |
| Pages: |
1112-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trajkovic K |
| Year: |
2008 |
| Journal: |
Science |
| Title: |
Ceramide triggers budding of exosome vesicles into multivesicular endosomes. |
| Volume: |
319 |
| Issue: |
5867 |
| Pages: |
1244-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stoffel W |
| Year: |
2007 |
| Journal: |
Am J Pathol |
| Title: |
Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression. |
| Volume: |
171 |
| Issue: |
1 |
| Pages: |
153-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nusshold C |
| Year: |
2013 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Endocytosis and intracellular processing of BODIPY-sphingomyelin by murine CATH.a neurons. |
| Volume: |
1831 |
| Issue: |
12 |
| Pages: |
1665-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adam-Klages S |
| Year: |
1998 |
| Journal: |
J Leukoc Biol |
| Title: |
Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. |
| Volume: |
63 |
| Issue: |
6 |
| Pages: |
678-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Z |
| Year: |
2013 |
| Journal: |
J Invest Dermatol |
| Title: |
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. |
| Volume: |
133 |
| Issue: |
3 |
| Pages: |
668-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
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2004 |
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Nucleic Acids Res |
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GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
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32 |
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Bedogni F |
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2021 |
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Front Mol Neurosci |
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Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
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WashU-HHMI Mouse EST Project |
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Velocigene |
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2008 |
| Journal: |
MGI Direct Data Submission |
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Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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Wellcome Trust Sanger Institute |
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2009 |
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MGI Direct Data Submission |
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Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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Helmholtz Zentrum Muenchen GmbH |
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2010 |
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MGI Direct Data Submission |
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Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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The Gene Ontology Consortium |
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2014 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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The transcriptional landscape of the mammalian genome. |
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Zambrowicz BP |
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2003 |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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2008 |
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Database Download |
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Mouse Gene Trap Data Load from dbGSS |
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UniProt-GOA |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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MGI Genome Annotation Group and UniGene Staff |
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MGI-UniGene Interconnection Effort |
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Annotation inferences using phylogenetic trees |
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Allen Institute for Brain Science |
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Allen Institute |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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J Biol Chem |
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| Publication |
| First Author: |
Feoktistova A |
| Year: |
2001 |
| Journal: |
Genetics |
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Coordination between fission yeast glucan formation and growth requires a sphingolipase activity. |
| Volume: |
158 |
| Issue: |
4 |
| Pages: |
1397-411 |
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes SMPD2 from animals, Isc1/Css1 from yeasts and sphingomyelinase C (also known as sph) from bacteria.Neutral sphingomyelinase (nSMase) sphingomyelin phosphodiesterase SMPD2 hydrolyzes sphingomyelin to phosphocholine and ceramide. SMPD2, differently to nSMase SMPD3, which is prominent in brain, is ubiquitously expressed []. Both are involved in vesicle budding from the plasma membrane [].Budding yeast Isc1 is inositol phosphosphingolipid phospholipase C that localizes to mitochondria in the post-diauxic phase of yeast growth []. Fission yeast Isc1 homologue, Css1, localizes to the entire plasma membrane and secretory pathway []. |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
83
 |
| Fragment?: |
false |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
419
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
419
 |
| Fragment?: |
false |
|
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•
•
•
•
|