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Search results 101 to 149 out of 149 for Smyd3

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Type Details Score
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
15235609 | -
First Author: Hamamoto R
Year: 2004
Journal: Nat Cell Biol
Title: SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
Volume: 6
Issue: 8
Pages: 731-40
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UniProt Feature
UniProt Feature
Begin: 1
Description: Histone-lysine N-methyltransferase SMYD3
Type: chain
End: 428
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Protein
A0A0A6YWP2
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: false
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Protein
D3YZ17
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: false
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Protein Domain
IPR025805 | Hist-Lys_N-MeTrfase_Smyd3
Type: Family
Description: This family of enzymes specifically methylate 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It plays an important role in transcriptional activation as a member of an RNA polymerase complex. It also binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences [].Methyltransferases (EC [intenz:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.
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HT Experiment
E-GEOD-67790 | Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver or colon cancer development
Series Id: GSE67790
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
27066749 | -
First Author: Van Aller GS
Year: 2016
Journal: Structure
Title: Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.
Volume: 24
Issue: 5
Pages: 774-781
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Publication
22419068 | -
First Author: Van Aller GS
Year: 2012
Journal: Epigenetics
Title: Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.
Volume: 7
Issue: 4
Pages: 340-3
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Interaction Experiment
Wang Z (2022)
Description: Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity.
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Publication
26985287 | -
First Author: Mitchell LH
Year: 2016
Journal: ACS Med Chem Lett
Title: Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
Volume: 7
Issue: 2
Pages: 134-8
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Protein
Q3TR55
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q3TIF7
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Allele
Smyd3<em1Smoc> | MGI:7292492
Name: SET and MYND domain containing 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6355210 | C57BL/6JSmoc-Smyd3<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
36273580 | -
First Author: Wang Z
Year: 2022
Journal: J Biol Chem
Title: Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity.
Volume: 298
Issue: 12
Pages: 102633
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Allele
Tg(Ttr-SMYD3)1Ital | MGI:5749481
Name: transgene insertion 1, Iannis Talianidis
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
27554136 | -
 
First Author: Giakountis A
Year: 2017
Journal: Semin Cancer Biol
Title: Smyd3-associated regulatory pathways in cancer.
Volume: 42
Pages: 70-80
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Protein Domain
IPR044420 | SMYD3_SET
Type: Domain
Description: This entry represents the SET domain of SET and MYND domain-containing protein 3 (SMYD3). SMYD3 functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4 []. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex []. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumours, and has been implicated as an oncogene in human malignancies []. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers [].The SMYD family consists of five members including SMYD1/2/3/4/5. They contain two highly conserved structural and functional domains, the SET and MYND domains. The SET domain is involved in lysine methylation, while the MYND domain is involved in protein-protein interaction. They are essential in several mammalian developmental pathways [, , , ].
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Strain
MGI:5749485 | STOCK Tg(Ttr-SMYD3)1Ital/Flmg
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Tg(Ttr-SMYD3)1Ital/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Publication
7897657 | -
First Author: Schluckebier G
Year: 1995
Journal: J Mol Biol
Title: Universal catalytic domain structure of AdoMet-dependent methyltransferases.
Volume: 247
Issue: 1
Pages: 16-20
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Publication
16225687 | -
 
First Author: Kozbial PZ
Year: 2005
Journal: BMC Struct Biol
Title: Natural history of S-adenosylmethionine-binding proteins.
Volume: 5
Pages: 19
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Publication
21858014 | -
First Author: Wlodarski T
Year: 2011
Journal: PLoS One
Title: Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome.
Volume: 6
Issue: 8
Pages: e23168
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Publication
12826405 | -
First Author: Schubert HL
Year: 2003
Journal: Trends Biochem Sci
Title: Many paths to methyltransfer: a chronicle of convergence.
Volume: 28
Issue: 6
Pages: 329-35
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Publication
37976356 | J:342854
First Author: Ikram S
Year: 2023
Journal: Sci Adv
Title: The SMYD3-MAP3K2 signaling axis promotes tumor aggressiveness and metastasis in prostate cancer.
Volume: 9
Issue: 46
Pages: eadi5921
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Publication
25125178 | -
First Author: Du SJ
Year: 2014
Journal: Anat Rec (Hoboken)
Title: SMYD proteins: key regulators in skeletal and cardiac muscle development and function.
Volume: 297
Issue: 9
Pages: 1650-62
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Publication
26101576 | -
First Author: Sweis RF
Year: 2015
Journal: ACS Med Chem Lett
Title: Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.
Volume: 6
Issue: 6
Pages: 695-700
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Publication
32408548 | -
 
First Author: Jarrell DK
Year: 2020
Journal: Vet Sci
Title: Characterizing the Role of SMYD2 in Mammalian Embryogenesis-Future Directions.
Volume: 7
Issue: 2
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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