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Search results 101 to 200 out of 998 for Snca

0.018s
Type Details Score
Publication
First Author: Du TT
Year: 2015
Journal: Autophagy
Title: GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.
Volume: 11
Issue: 10
Pages: 1803-20
Publication  
First Author: Alvarez-Castelao B
Year: 2014
Journal: Front Aging Neurosci
Title: Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls.
Volume: 6
Pages: 169
Publication  
First Author: Pavia-Collado R
Year: 2021
Journal: Int J Mol Sci
Title: Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.
Volume: 22
Issue: 6
Publication  
First Author: Piltonen M
Year: 2013
Journal: Neuroscience
Title: Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains.
Volume: 231
Pages: 157-68
Publication
First Author: Ryan BJ
Year: 2021
Journal: J Neurosci
Title: REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.
Volume: 41
Issue: 16
Pages: 3731-3746
Publication
First Author: Li N
Year: 2020
Journal: J Neuroinflammation
Title: Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein.
Volume: 17
Issue: 1
Pages: 272
Publication
First Author: Michell AW
Year: 2007
Journal: Cell Transplant
Title: The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease.
Volume: 16
Issue: 5
Pages: 461-74
Publication
First Author: Tofaris GK
Year: 2006
Journal: J Neurosci
Title: Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.
Volume: 26
Issue: 15
Pages: 3942-50
Publication
First Author: Gispert S
Year: 2003
Journal: Mol Cell Neurosci
Title: Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.
Volume: 24
Issue: 2
Pages: 419-29
Publication
First Author: Desplats P
Year: 2011
Journal: J Biol Chem
Title: Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases.
Volume: 286
Issue: 11
Pages: 9031-7
Publication
First Author: Roberts BM
Year: 2020
Journal: Nat Commun
Title: GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Volume: 11
Issue: 1
Pages: 4958
Publication
First Author: Martin LJ
Year: 2014
Journal: Neurobiol Aging
Title: Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice.
Volume: 35
Issue: 5
Pages: 1132-52
Publication
First Author: Kilfeather P
Year: 2024
Journal: Cell Rep
Title: Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease.
Volume: 43
Issue: 3
Pages: 113784
Publication
First Author: Parmasad JA
Year: 2024
Journal: Cell Death Dis
Title: Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
Volume: 15
Issue: 4
Pages: 246
Publication
First Author: Kett LR
Year: 2015
Journal: J Neurosci
Title: α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.
Volume: 35
Issue: 14
Pages: 5724-42
Publication
First Author: Rothman SM
Year: 2014
Journal: Neurobiol Aging
Title: Metabolic abnormalities and hypoleptinemia in α-synuclein A53T mutant mice.
Volume: 35
Issue: 5
Pages: 1153-61
Publication
First Author: Pavlou MAS
Year: 2017
Journal: Mol Neurobiol
Title: Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32.
Volume: 54
Issue: 6
Pages: 4257-4270
Publication
First Author: Yang Y
Year: 2024
Journal: Mov Disord
Title: Erythrocytic α-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease.
Volume: 39
Issue: 1
Pages: 40-52
Publication
First Author: Prasad K
Year: 2011
Journal: Eur J Neurosci
Title: Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background.
Volume: 33
Issue: 4
Pages: 642-56
Publication
First Author: Kline RA
Year: 2017
Journal: PLoS Genet
Title: Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.
Volume: 13
Issue: 3
Pages: e1006680
Publication
First Author: Burré J
Year: 2010
Journal: Science
Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Volume: 329
Issue: 5999
Pages: 1663-7
Publication
First Author: Gallardo G
Year: 2008
Journal: Nat Neurosci
Title: A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.
Volume: 11
Issue: 3
Pages: 301-8
Publication
First Author: Migdalska-Richards A
Year: 2016
Journal: Ann Neurol
Title: Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.
Volume: 80
Issue: 5
Pages: 766-775
Publication
First Author: Vargas KJ
Year: 2017
Journal: Cell Rep
Title: Synucleins Have Multiple Effects on Presynaptic Architecture.
Volume: 18
Issue: 1
Pages: 161-173
Publication
First Author: Rahimi-Balaei M
Year: 2019
Journal: PLoS One
Title: Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning.
Volume: 14
Issue: 9
Pages: e0222234
Publication  
First Author: Chandra R
Year: 2017
Journal: JCI Insight
Title: α-Synuclein in gut endocrine cells and its implications for Parkinson's disease.
Volume: 2
Issue: 12
Publication  
First Author: Wang ZH
Year: 2018
Journal: JCI Insight
Title: BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
Volume: 3
Issue: 16
Publication
First Author: Yun SP
Year: 2018
Journal: Mol Neurodegener
Title: α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.
Volume: 13
Issue: 1
Pages: 1
Publication
First Author: Ho PW
Year: 2020
Journal: Autophagy
Title: Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Volume: 16
Issue: 2
Pages: 347-370
Publication  
First Author: Martinez Hernandez A
Year: 2021
Journal: Front Neurosci
Title: Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein.
Volume: 15
Pages: 643391
Publication
First Author: Krejciova Z
Year: 2019
Journal: Acta Neuropathol Commun
Title: Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.
Volume: 7
Issue: 1
Pages: 81
Publication
First Author: Hunn BHM
Year: 2019
Journal: Cell Rep
Title: Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.
Volume: 29
Issue: 4
Pages: 920-931.e7
Publication
First Author: Xie Q
Year: 2013
Journal: PLoS One
Title: Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.
Volume: 8
Issue: 1
Pages: e54507
Publication  
First Author: Chandra R
Year: 2023
Journal: JCI Insight
Title: Gut mucosal cells transfer α-synuclein to the vagus nerve.
Volume: 8
Issue: 23
Publication
First Author: Chandra S
Year: 2005
Journal: Cell
Title: Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.
Volume: 123
Issue: 3
Pages: 383-96
Publication
First Author: Lin X
Year: 2009
Journal: Neuron
Title: Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Volume: 64
Issue: 6
Pages: 807-27
Publication
First Author: Benzow K
Year: 2024
Journal: Alzheimers Dement
Title: Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Volume: 20
Issue: 4
Pages: 3080-3087
Allele
Name: synuclein, alpha; targeted mutation 1.1, Sulev Koks
Allele Type: Targeted
Attribute String: Humanized sequence
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Hong L
Year: 1998
Journal: Neuroreport
Title: The cDNA cloning and ontogeny of mouse alpha-synuclein.
Volume: 9
Issue: 6
Pages: 1239-43
Publication
First Author: Burré J
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
Volume: 111
Issue: 40
Pages: E4274-83
Publication
First Author: Siebert H
Year: 2010
Journal: J Neurochem
Title: Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.
Volume: 114
Issue: 4
Pages: 1007-18
Publication  
First Author: Chadchankar H
Year: 2011
Journal: Brain Res
Title: Sub-regional differences and mechanisms of the short-term plasticity of dopamine overflow in striatum in mice lacking alpha-synuclein.
Volume: 1423
Pages: 67-76
Publication
First Author: Smith AN
Year: 2023
Journal: Platelets
Title: α-Synuclein is the major platelet isoform but is dispensable for activation, secretion, and thrombosis.
Volume: 34
Issue: 1
Pages: 2267147
Publication
First Author: Dhillon JS
Year: 2017
Journal: PLoS One
Title: A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.
Volume: 12
Issue: 9
Pages: e0184731
Publication
First Author: Peña-Oliver Y
Year: 2012
Journal: Genes Brain Behav
Title: Deletion of alpha-synuclein decreases impulsivity in mice.
Volume: 11
Issue: 2
Pages: 137-46
Publication
First Author: Luk KC
Year: 2012
Journal: J Exp Med
Title: Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.
Volume: 209
Issue: 5
Pages: 975-86
Publication
First Author: Martín ED
Year: 2004
Journal: Eur J Neurosci
Title: Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice.
Volume: 20
Issue: 11
Pages: 3085-91
Publication
First Author: Duka T
Year: 2006
Journal: FASEB J
Title: Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism.
Volume: 20
Issue: 13
Pages: 2302-12
Publication
First Author: Wang L
Year: 2014
Journal: Curr Biol
Title: α-synuclein multimers cluster synaptic vesicles and attenuate recycling.
Volume: 24
Issue: 19
Pages: 2319-26
Publication    
First Author: Chen L
Year: 2022
Journal: Elife
Title: Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala.
Volume: 11
Publication
First Author: Luk KC
Year: 2016
Journal: Cell Rep
Title: Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity.
Volume: 16
Issue: 12
Pages: 3373-3387
Publication
First Author: Gao HM
Year: 2008
Journal: J Neurosci
Title: Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration.
Volume: 28
Issue: 30
Pages: 7687-98
Publication
First Author: Klivenyi P
Year: 2006
Journal: Neurobiol Dis
Title: Mice lacking alpha-synuclein are resistant to mitochondrial toxins.
Volume: 21
Issue: 3
Pages: 541-8
Publication  
First Author: Wijesekara N
Year: 2021
Journal: Front Aging Neurosci
Title: α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport.
Volume: 13
Pages: 665348
Publication
First Author: Reznichenko L
Year: 2012
Journal: J Neurosci
Title: In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy.
Volume: 32
Issue: 29
Pages: 9992-8
Publication
First Author: Dodson PD
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.
Volume: 113
Issue: 15
Pages: E2180-8
Publication
First Author: Kokhan VS
Year: 2012
Journal: Behav Brain Res
Title: α-Synuclein knockout mice have cognitive impairments.
Volume: 231
Issue: 1
Pages: 226-30
Publication
First Author: Dening Y
Year: 2022
Journal: Sci Rep
Title: Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.
Volume: 12
Issue: 1
Pages: 21951
Publication
First Author: Peng C
Year: 2018
Journal: Nature
Title: Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.
Volume: 557
Issue: 7706
Pages: 558-563
Publication
First Author: Sheng L
Year: 2020
Journal: Acta Neuropathol Commun
Title: Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.
Volume: 8
Issue: 1
Pages: 102
Publication  
First Author: Ninkina N
Year: 2020
Journal: Neurobiol Aging
Title: Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice.
Volume: 91
Pages: 76-87
Publication
First Author: Taguchi K
Year: 2020
Journal: Mol Neurobiol
Title: α-Synuclein Promotes Maturation of Immature Juxtaglomerular Neurons in the Mouse Olfactory Bulb.
Volume: 57
Issue: 3
Pages: 1291-1304
Publication
First Author: Rappley I
Year: 2009
Journal: J Neurochem
Title: Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype.
Volume: 111
Issue: 1
Pages: 15-25
Publication
First Author: Perez-Villalba A
Year: 2018
Journal: J Neurosci
Title: Synaptic Regulator α-Synuclein in Dopaminergic Fibers Is Essentially Required for the Maintenance of Subependymal Neural Stem Cells.
Volume: 38
Issue: 4
Pages: 814-825
Publication
First Author: Wu Q
Year: 2019
Journal: J Neurosci
Title: α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons.
Volume: 39
Issue: 26
Pages: 5080-5094
Publication
First Author: Carballo-Carbajal I
Year: 2019
Journal: Nat Commun
Title: Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.
Volume: 10
Issue: 1
Pages: 973
Publication
First Author: Meng L
Year: 2023
Journal: Sci Adv
Title: The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.
Volume: 9
Issue: 44
Pages: eadj1092
Publication
First Author: Kim S
Year: 2019
Journal: Neuron
Title: Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Volume: 103
Issue: 4
Pages: 627-641.e7
Publication
First Author: Scott D
Year: 2012
Journal: J Neurosci
Title: α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis.
Volume: 32
Issue: 30
Pages: 10129-35
Publication
First Author: Spencer B
Year: 2016
Journal: J Neurosci
Title: Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.
Volume: 36
Issue: 30
Pages: 7971-84
Publication
First Author: Xiao W
Year: 2014
Journal: Immunobiology
Title: Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.
Volume: 219
Issue: 11
Pages: 836-44
Publication
First Author: Sauerbeck AD
Year: 2021
Journal: Sci Rep
Title: Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss.
Volume: 11
Issue: 1
Pages: 11720
Publication  
First Author: Liu W
Year: 2022
Journal: Front Neurol
Title: Characterization of a Novel Monoclonal Antibody for Serine-129 Phosphorylated α-Synuclein: A Potential Application for Clinical and Basic Research.
Volume: 13
Pages: 821792
Publication
First Author: Mosharov EV
Year: 2009
Journal: Neuron
Title: Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons.
Volume: 62
Issue: 2
Pages: 218-29
Publication  
First Author: Pieger K
Year: 2022
Journal: Biomolecules
Title: Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation.
Volume: 12
Issue: 8
Publication
First Author: Barth M
Year: 2021
Journal: Mol Neurodegener
Title: Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures.
Volume: 16
Issue: 1
Pages: 54
Publication
First Author: Fares MB
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease.
Volume: 113
Issue: 7
Pages: E912-21
Publication
First Author: Blumenstock S
Year: 2017
Journal: EMBO Mol Med
Title: Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex.
Volume: 9
Issue: 5
Pages: 716-731
Publication  
First Author: Minakaki G
Year: 2019
Journal: Behav Brain Res
Title: Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.
Volume: 363
Pages: 199-215
Publication  
First Author: Swaminathan M
Year: 2019
Journal: Neuroscience
Title: α-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon.
Volume: 423
Pages: 76-85
Publication  
First Author: Benskey MJ
Year: 2018
Journal: Front Mol Neurosci
Title: Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity.
Volume: 11
Pages: 36