Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:1004025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828368 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009174_07 |
|
Specimen Label: |
euxassay_009174_07 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1004025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828368 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009174_11 |
|
Specimen Label: |
euxassay_009174_11 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1004025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828368 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009174_12 |
|
Specimen Label: |
euxassay_009174_12 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1004025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828368 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009174_13 |
|
Specimen Label: |
euxassay_009174_13 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1004025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828368 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009174_15 |
|
Specimen Label: |
euxassay_009174_15 |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1004025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828368 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009174_16 |
|
Specimen Label: |
euxassay_009174_16 |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu Z |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. |
Volume: |
28 |
Issue: |
13 |
Pages: |
1890-903 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ghai R |
Year: |
2014 |
Journal: |
Methods Enzymol |
Title: |
Measuring interactions of FERM domain-containing sorting Nexin proteins with endosomal lipids and cargo molecules. |
Volume: |
534 |
|
Pages: |
331-49 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
SNX17/27/31 are known as PX-FERM proteins, a sub-group of the PX superfamily that contain a defining PtdInsP-binding PX domain, and a C-terminal 4.1, ezrin, radixin, moesin (FERM) domain with an atypical tertiary structure []. They are modular peripheralmembrane proteins that act as central scaffolds mediating protein-lipid interactions, cargo binding, and regulatory protein recruitment [].SNX17 is a critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. It binds to Asn-Pro-Xaa-Tyr (NPxY) sequences in the cytoplasmic tails of cargo such as LDL receptors and the amyloid precursor protein []. SNX27 is a core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. It specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C terminus []. Its PDZ domain mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B) [], while its PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early endosome membranes []. SNX31 is a sorting nexin that binds to PtdIns3P-enriched lipids via its N-terminal PX-domain. It also binds to uroplakins []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghai R |
Year: |
2015 |
Journal: |
J Cell Sci |
Title: |
Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. |
Volume: |
128 |
Issue: |
3 |
Pages: |
553-65 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
138
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
439
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
67
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
169
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
110
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
87
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghai R |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. |
Volume: |
108 |
Issue: |
19 |
Pages: |
7763-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lauffer BE |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. |
Volume: |
190 |
Issue: |
4 |
Pages: |
565-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steinberg F |
Year: |
2013 |
Journal: |
Nat Cell Biol |
Title: |
A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. |
Volume: |
15 |
Issue: |
5 |
Pages: |
461-71 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
470
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
435
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
539
 |
Fragment?: |
false |
|
•
•
•
•
•
|