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Search results 101 to 144 out of 144 for Socs7

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Type Details Score
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GXD Expression
GXD Expression
   
Probe: MGI:4457009
Assay Type: Western blot
Annotation Date: 2020-05-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6430616
Age: postnatal
Image: 8
Specimen Label: SOCS7 +/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4457009
Assay Type: Western blot
Annotation Date: 2020-05-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6430616
Age: postnatal
Image: 8
Specimen Label: SOCS7 +/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4457009
Assay Type: Western blot
Annotation Date: 2020-05-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6430616
Age: postnatal
Image: 8
Specimen Label: SOCS7 -/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6430195
Assay Type: Western blot
Annotation Date: 2020-05-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6430617
Age: postnatal
Image: 8
Specimen Label: SOCS7 +/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6430195
Assay Type: Western blot
Annotation Date: 2020-05-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6430617
Age: postnatal
Image: 8
Specimen Label: SOCS7 +/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6430195
Assay Type: Western blot
Annotation Date: 2020-05-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6430617
Age: postnatal
Image: 8
Specimen Label: SOCS7 -/-
Detected: true
Specimen Num: 3
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Allele
Socs7<tm1c(EUCOMM)Wtsi> | MGI:5545789
Name: suppressor of cytokine signaling 7; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
28240316 | J:323516
 
First Author: Yang R
Year: 2017
Journal: Sci Rep
Title: p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO.
Volume: 7
Pages: 43409
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GXD Expression
GXD Expression
 
Probe: MGI:5749732
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430465
Age: postnatal day 20
Note: A low percentage of wild type rod bipolar cells (Otx2+ and Prkca+) were detected in the inner half of the inner nuclear layer.
Specimen Label: not shown SOCS7 Wt
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:5749732
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430465
Age: postnatal day 20
Note: In the knockout retinas, a higher percentage of rod bipolar cells were ectopically localized at the inner half of the inner nuclear layer.
Specimen Label: not shown SOCS7 Mut
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:6430205
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430451
Age: postnatal day 20
Note: A low percentage of wild type rod bipolar cells (Otx2+ and Prkca+) were detected in the inner half of the inner nuclear layer.
Specimen Label: not shown SOCS7 Wt
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:6430205
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430451
Age: postnatal day 20
Note: In the knockout retinas, a higher percentage of rod bipolar cells were ectopically localized at the inner half of the inner nuclear layer.
Specimen Label: not shown SOCS7 Mut
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:6195063
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430500
Age: postnatal day 20
Note: Expression was detected in cone photoreceptors in the outer side of the outer nuclear layer.
Specimen Label: not shown SOCS7 Wt
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:6195063
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430500
Age: postnatal day 20
Note: The localization of cone photoreceptors was not disrupted in the knockout.
Specimen Label: not shown SOCS7 Mut
Detected: true
Specimen Num: 17
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Protein
Q91ZA6
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Interaction Experiment
Fu B (2020)
Description: PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure.
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Protein Domain
IPR035866 | SOCS7_SH2
Type: Domain
Description: SOCS7 is a member of the suppressor of cytokine signaling family of proteins. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation []. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA [].This entry represents the SH2 domain of SOCS7.
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Protein Coding Gene
MGI:1914546 | Socs4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR037346 | SOCS7_SOCS
Type: Domain
Description: This entry represents the SOCS box domain of SOCS7.SOCS7 is a member of the suppressor of cytokine signaling family of proteins. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation []. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
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Publication
9869640 | -
First Author: Kamura T
Year: 1998
Journal: Genes Dev
Title: The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
Volume: 12
Issue: 24
Pages: 3872-81
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Publication
16675548 | -
First Author: Bullock AN
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Volume: 103
Issue: 20
Pages: 7637-42
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