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Search results 101 to 110 out of 110 for Srcap

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0.016s

Type

Details

Score

Publication

30886158 | J:275707

First Author:	Eguchi K
Year:	2019
Journal:	Sci Rep
Title:	Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055.
Volume:	9
Issue:	1
Pages:	4812

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Publication

16904321 | -

First Author:	Squatrito M
Year:	2006
Journal:	Trends Cell Biol
Title:	Tip60 in DNA damage response and growth control: many tricks in one HAT.
Volume:	16
Issue:	9
Pages:	433-42

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Publication

19845771 | J:158320

First Author:	Negishi M
Year:	2009
Journal:	Genes Cells
Title:	Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.
Volume:	14
Issue:	11
Pages:	1347-57

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Publication

20864525 | -

First Author:	Lee GE
Year:	2010
Journal:	J Biol Chem
Title:	DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair.
Volume:	285
Issue:	48
Pages:	37630-40

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Protein Domain

IPR027109 | Swc4/Dmap1

Type:

Family

Description:

This entry consists of the SWR1-complex protein 4 (Swc4) from yeast, also known as EAF2, and its mammalian homologue DNA methyltransferase 1-associated protein 1 (Dmap1) []. They are components of the NuA4 histone acetyltransferase (HAT) complex, which is highly conserved in eukaryotes. NuA4 acetylates the nucleosomal histones H4 and H2A and plays primary roles in transcription, DNA repair, and cell cycle control [, ].The subunits of the NuA4 complex are shared by the ATP-dependent chromatin-remodeling SWR1 complex in yeast and its human orthologue, Snf 2-related CREB-binding protein (CBP) activator protein (SRCAP) complex. The mammalian NuA4 complex includes the SRCAP complex, and thus combines the functions of the yeast NuA4 and Swr1 complexes []. The SWR1/SRCAP complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling [, , ]. Dmap1 was originally identified as an interacting molecule with DNA methyltransferase 1 (DNMT1) and plays a crucial role in DNA repair. It is indispensable for the maintenance of chromosomal integrity and might function as a tumor suppressor [].

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Protein

Q9JI44

Organism:	Mus musculus/domesticus
Length:	468
Fragment?:	false

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Publication

14645854 | -

First Author:	Mizuguchi G
Year:	2004
Journal:	Science
Title:	ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.
Volume:	303
Issue:	5656
Pages:	343-8

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Publication

14690608 | -

First Author:	Krogan NJ
Year:	2003
Journal:	Mol Cell
Title:	A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.
Volume:	12
Issue:	6
Pages:	1565-76

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Publication

14966270 | J:320265

First Author:	Doyon Y
Year:	2004
Journal:	Mol Cell Biol
Title:	Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
Volume:	24
Issue:	5
Pages:	1884-96

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Publication

15196461 | -

First Author:	Doyon Y
Year:	2004
Journal:	Curr Opin Genet Dev
Title:	The highly conserved and multifunctional NuA4 HAT complex.
Volume:	14
Issue:	2
Pages:	147-54

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