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Search results 101 to 118 out of 118 for Srrm2

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Type Details Score
Protein
A0A087WR98
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
J9QHX6
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
Q6ZPH0
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: true
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Protein Domain
IPR052109 | SRRM
Type: Family
Description: This family consists of serine/arginine repetitive matrix proteins (SRRM), including SRRM2, SRRM3, and SRRM4, which are found primarily in eukaryotes. They function as RNA splicing factors that regulate alternative splicing and are components of the spliceosome. SRRM2 is required for pre-mRNA splicing and is a component of the minor spliceosome, which splices U12-type introns. SRRM3 and SRRM4 regulate the inclusion of microexons in mRNA transcripts and are essential for neural cell differentiation, motor coordination, and nervous system development [, , , , , , ]. In cortical neurons, SRRM3 and SRRM4 act redundantly to regulate alternative splicing events, such as the inactivation of the transcriptional repressor REST []. SRRM3 also mediates microexon inclusion in pancreatic islets, regulating insulin and glucagon secretion [].
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Protein
Q8BTI8
Organism: Mus musculus/domesticus
Length: 2703  
Fragment?: false
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Protein
A0A087WRX8
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Protein
A0A3B2W3Z4
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Protein
Q05BN4
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: true
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Protein
Q05CY4
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Protein
Q3TR34
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: true
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Publication
19854871 | -
First Author: Grainger RJ
Year: 2009
Journal: RNA
Title: Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome.
Volume: 15
Issue: 12
Pages: 2161-73
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Protein
Q80WV7
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
D3Z3C2
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
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Protein
H7BWX3
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Publication
11991638 | -
First Author: Jurica MS
Year: 2002
Journal: RNA
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
Volume: 8
Issue: 4
Pages: 426-39
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Publication
30705154 | -
First Author: Fica SM
Year: 2019
Journal: Science
Title: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
Volume: 363
Issue: 6428
Pages: 710-714
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Publication
29360106 | -
First Author: Zhang X
Year: 2018
Journal: Cell Res
Title: Structure of the human activated spliceosome in three conformational states.
Volume: 28
Issue: 3
Pages: 307-322
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Publication
29301961 | -
First Author: Zhan X
Year: 2018
Journal: Science
Title: Structure of a human catalytic step I spliceosome.
Volume: 359
Issue: 6375
Pages: 537-545
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