Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
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•
|
Allele |
Name: |
transgene insertion IL254, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Cavaloc Y |
Year: |
1994 |
Journal: |
EMBO J |
Title: |
Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. |
Volume: |
13 |
Issue: |
11 |
Pages: |
2639-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swartz JE |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element. |
Volume: |
282 |
Issue: |
27 |
Pages: |
19844-53 |
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•
•
•
•
•
|
Publication |
First Author: |
Ding S |
Year: |
2012 |
Journal: |
Neurobiol Aging |
Title: |
Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A. |
Volume: |
33 |
Issue: |
7 |
Pages: |
1389-99 |
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•
•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the RNA recognition motif (RRM) of SRSF7 (also termed splicing factor 9G8), which is a splicing regulatory serine/arginine (SR) protein that plays a crucial role in both constitutive splicing and alternative splicing of many pre-mRNAs []. Its localization and functions are tightly regulated by phosphorylation. SRSF7 is predominantly present in the nucleus and can shuttle between nucleus and cytoplasm. It cooperates with the export protein, Tap/NXF1, helps mRNA export to the cytoplasm, and enhances the expression of unspliced mRNA []. SRSF7 inhibits tau E10 inclusion through directly interacting with the proximal downstream intron of E10, a clustering region for frontotemporal dementia with Parkinsonism (FTDP) mutations []. SRSF7 contains a single N-terminal RNA recognition motif (RRM), followed by a CCHC-type zinc knuckle motif in itsmedian region, and a C-terminal RS domain rich in serine-arginine dipeptides. |
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Strain |
Attribute String: |
mutant stock, transgenic |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
235
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
137
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
238
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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