MouseMine: Keyword Search

Publication

First Author:	Diez-Roux G
Year:	2011
Journal:	PLoS Biol
Title:	A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume:	9
Issue:	1
Pages:	e1000582

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Publication

- | J:75000

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Mouse Genome Informatics Computational Sequence to Gene Associations

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Publication

- | J:157972

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2010
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).

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Publication

- | J:161428

First Author:	Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year:	2010

Title:	Annotation inferences using phylogenetic trees

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Publication

- | J:63103

First Author:	Mouse Genome Database and National Center for Biotechnology Information
Year:	2000
Journal:	Database Release
Title:	Entrez Gene Load

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Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

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Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

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Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

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Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

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Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

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Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

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Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Publication

8684611 | -

First Author:	Tallent M
Year:	1996
Journal:	Neuroscience
Title:	Somatostatin receptor subtypes SSTR2 and SSTR5 couple negatively to an L-type Ca2+ current in the pituitary cell line AtT-20.
Volume:	71
Issue:	4
Pages:	1073-81

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Publication

21203507 | J:168333

First Author:	Ohigashi I
Year:	2010
Journal:	PLoS One
Title:	Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
Volume:	5
Issue:	12
Pages:	e14391

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Allele

Tg(CD3E)26Cpt | MGI:3052629

Name:	transgene insertion 26, Cox Terhorst
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

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Publication

9886373 | J:111198

First Author:	Wang B
Year:	1999
Journal:	J Immunol
Title:	T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta.
Volume:	162
Issue:	1
Pages:	88-94

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Strain

MGI:2162165 | B6;CBA-Tg(CD3E)26Cpt/J

Attribute String:

mutant stock, transgenic

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Publication

7937778 | J:81711

First Author:	Wang B
Year:	1994
Journal:	Proc Natl Acad Sci U S A
Title:	A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.
Volume:	91
Issue:	20
Pages:	9402-6

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Publication

10725235 | J:61090

First Author:	van Ewijk W
Year:	2000
Journal:	Development
Title:	Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets.
Volume:	127
Issue:	8
Pages:	1583-91

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Publication

17664261 | J:125284

First Author:	Kechichian TB
Year:	2007
Journal:	Infect Immun
Title:	Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice.
Volume:	75
Issue:	10
Pages:	4792-8

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Publication

19662637 | J:152176

First Author:	Roberts NA
Year:	2009
Journal:	Eur J Immunol
Title:	Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult.
Volume:	39
Issue:	9
Pages:	2395-402

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Publication

7621076 | J:27235

First Author:	Holländer GA
Year:	1995
Journal:	Immunity
Title:	Severe colitis in mice with aberrant thymic selection.
Volume:	3
Issue:	1
Pages:	27-38

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Publication

7794823 | J:28356

First Author:	Wang B
Year:	1995
Journal:	Int Immunol
Title:	Over-expression of CD3 epsilon transgenes blocks T lymphocyte development.
Volume:	7
Issue:	3
Pages:	435-48

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Publication

25302710 | J:223456

First Author:	Sheng-Fowler L
Year:	2014
Journal:	PLoS One
Title:	A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc.
Volume:	9
Issue:	10
Pages:	e108926

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Genotype

Symbol:	Tg(CD3E)26Cpt/Tg(CD3E)26Cpt
Background:	involves: C57BL/6J * CBA/J
Zygosity:	hm
Has Mutant Allele:	true

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Genotype

Symbol:	Cd3e/Cd3e Tg(CD3E)26Cpt/?
Background:	involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity:	cx
Has Mutant Allele:	true

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Publication

9686607 | J:49819

First Author:	Babu S
Year:	1998
Journal:	J Immunol
Title:	Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice.
Volume:	161
Issue:	3
Pages:	1428-32

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Publication

7830770 | J:153273

First Author:	Holländer GA
Year:	1995
Journal:	Nature
Title:	Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.
Volume:	373
Issue:	6512
Pages:	350-3

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Publication

10411532 | J:56503

First Author:	Ashkar AA
Year:	1999
Journal:	Biol Reprod
Title:	Interferon-gamma contributes to the normalcy of murine pregnancy.
Volume:	61
Issue:	2
Pages:	493-502

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Strain

MGI:2174657 | STOCK Rag1<tm1Mom> Tg(CD3E)26Cpt/J

Attribute String:

mutant stock, targeted mutation, transgenic

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Publication

19731363 | J:153366

First Author:	Bekiaris V
Year:	2009
Journal:	Eur J Immunol
Title:	NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism.
Volume:	39
Issue:	10
Pages:	2800-8

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Publication

9885898 | J:54756

First Author:	Wang N
Year:	1998
Journal:	Int Immunol
Title:	Expression of a CD3 epsilon transgene in CD3 epsilon(null) mice does not restore CD3 gamma and delta expression but efficiently rescues T cell development from a subpopulation of prothymocytes.
Volume:	10
Issue:	12
Pages:	1777-88

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Publication

16472597 | J:124921

First Author:	Abadía-Molina AC
Year:	2006
Journal:	Gastroenterology
Title:	CD48 controls T-cell and antigen-presenting cell functions in experimental colitis.
Volume:	130
Issue:	2
Pages:	424-34

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Publication

25895971 | J:229776

First Author:	Farnoud AM
Year:	2015
Journal:	Infect Immun
Title:	The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway.
Volume:	83
Issue:	7
Pages:	2705-13

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Publication

10657637 | J:60329

First Author:	Klug DB
Year:	2000
Journal:	J Immunol
Title:	Transgenic expression of cyclin D1 in thymic epithelial precursors promotes epithelial and T cell development.
Volume:	164
Issue:	4
Pages:	1881-8

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Publication

31503512 | J:282930

First Author:	Jepsen SL
Year:	2019
Journal:	Am J Physiol Endocrinol Metab
Title:	Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice.
Volume:	317
Issue:	6
Pages:	E1081-E1093

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Publication

8792932 | J:113082

First Author:	Guimond MJ
Year:	1996
Journal:	Am J Reprod Immunol
Title:	Pregnancy-associated uterine granulated metrial gland cells in mutant and transgenic mice.
Volume:	35
Issue:	6
Pages:	501-9

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Publication

9794386 | J:81712

First Author:	Tokoro Y
Year:	1998
Journal:	J Immunol
Title:	A mouse carrying genetic defect in the choice between T and B lymphocytes.
Volume:	161
Issue:	9
Pages:	4591-8

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Publication

16920967 | J:139540

First Author:	Louten J
Year:	2006
Journal:	J Immunol
Title:	Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection.
Volume:	177
Issue:	5
Pages:	3266-72

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Publication

9002646 | J:134589

First Author:	Guimond MJ
Year:	1997
Journal:	Biol Reprod
Title:	Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice.
Volume:	56
Issue:	1
Pages:	169-79

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Publication

11390489 | J:132607

First Author:	Huber VC
Year:	2001
Journal:	J Immunol
Title:	Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections.
Volume:	166
Issue:	12
Pages:	7381-8

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Publication

12218095 | J:120433

First Author:	Klug DB
Year:	2002
Journal:	J Immunol
Title:	Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus.
Volume:	169
Issue:	6
Pages:	2842-5

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Publication

12496386 | J:127041

First Author:	Pozdnyakova O
Year:	2003
Journal:	J Immunol
Title:	Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice.
Volume:	170
Issue:	1
Pages:	84-90

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Publication

16406265 | J:179569

First Author:	Wang XP
Year:	2006
Journal:	Mol Cell Endocrinol
Title:	Alterations in glucose homeostasis in SSTR1 gene-ablated mice.
Volume:	247
Issue:	1-2
Pages:	82-90

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Publication

30282821 | J:279106

First Author:	Yamamoto M
Year:	2018
Journal:	JCI Insight
Title:	Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function.
Volume:	3
Issue:	19

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Publication

10925280 | J:63747

First Author:	Zuklys S
Year:	2000
Journal:	J Immunol
Title:	Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Volume:	165
Issue:	4
Pages:	1976-83

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Publication

19918778 | J:157679

First Author:	Saade M
Year:	2010
Journal:	Eur J Immunol
Title:	Spatial (Tbata) expression in mature medullary thymic epithelial cells.
Volume:	40
Issue:	2
Pages:	530-8

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Publication

10614629 | J:59133

First Author:	Strowski MZ
Year:	2000
Journal:	Endocrinology
Title:	Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.
Volume:	141
Issue:	1
Pages:	111-7

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Publication

22855716 | J:189848

First Author:	Withers DR
Year:	2012
Journal:	J Immunol
Title:	Cutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue.
Volume:	189
Issue:	5
Pages:	2094-8

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Protein

D7NVX4

Organism:	Mus musculus/domesticus
Length:	127
Fragment?:	false

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Publication

18406829 | -

First Author:	Patel YC
Year:	1997
Journal:	Trends Endocrinol Metab
Title:	Somatostatin receptors.
Volume:	8
Issue:	10
Pages:	398-405

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Publication

9892225 | -

First Author:	Kumar U
Year:	1999
Journal:	Diabetes
Title:	Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.
Volume:	48
Issue:	1
Pages:	77-85

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Publication

14966206 | -

First Author:	Ludvigsen E
Year:	2004
Journal:	J Histochem Cytochem
Title:	Expression and distribution of somatostatin receptor subtypes in the pancreatic islets of mice and rats.
Volume:	52
Issue:	3
Pages:	391-400

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Publication

10804219 | -

First Author:	Schreff M
Year:	2000
Journal:	J Neurosci
Title:	Distribution, targeting, and internalization of the sst4 somatostatin receptor in rat brain.
Volume:	20
Issue:	10
Pages:	3785-97

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Publication

12639942 | -

First Author:	Florio T
Year:	2003
Journal:	Endocrinology
Title:	Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.
Volume:	144
Issue:	4
Pages:	1574-84

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Protein Domain

IPR002074 | Somatstn_rcpt_2

Type:

Family

Description:

Somatostatin (SST), also known as somatotropin release-inhibiting factor (SRIF), is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Somatostatin has a wide distribution throughout the central nervous system (CNS) as well as in peripheral tissues, for example in the pituitary, pancreas and stomach. The various actions of somatostatin are mediated by a family of rhodopsin-like G protein-coupled receptors, which comprise of five distinct subtypes: Somatostatin receptor 1 (SSTR1), Somatostatin receptor 2 (SSTR2), Somatostatin receptor 3 (SSTR3), Somatostatin receptor 4 (SSTR4) and Somatostatin receptor 5 (SSTR5) [, , ]. These subtypes are widely expressed in many tissues [, , , , , ], and frequently multiple subtypes coexist in the same cell []. The somatostatin receptor subtypes also share common signalling pathways, such as the inhibition of adenylyl cyclase [, ], activation of phosphotyrosine phosphatase (PTP), and modulation of mitogen-activated protein kinase (MAPK) through G protein-dependent mechanisms. Some of the subtypes are also coupled to inward rectifying K+ channels (SSTR2, SSTR3, SSTR4, SSTR5) [, ], to voltage-dependent Ca2+ channels (SSTR1, SSTR2) [], to an Na+/H+ exchanger (SSTR1), AMPA/kainate glutamate channels (SSTR1, SSTR2), phospholipase C (SSTR2, SSTR5), and phospholipase A2 (SSTR4) []. Amongst the wide spectrum of somatostatin effects, several biological responses have been identified that display absolute or relative subtype selectivity. These include GH secretion (SSTR2 and 5), insulin secretion (SSTR5), glucagon secretion (SSTR2), and immune responses (SSTR2) [].This entry represents SSTR2. In humans has been found in high levels the brain, kidney and pituitary, with lower levels in the jejunum, pancreas, colon and liver. All five human somatostatin receptors expressed in COS-7 cells are coupled to activation of phosphoinositide (PI)-specific PLC-beta; and Ca2+ mobilisation via pertussis toxin-sensitive G protein(s) with an order of potency of SSTR5 >SSTR2 >SSTR3 >SSTR4 >SSTR1 [].

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Protein Domain

IPR001116 | Somatstn_rcpt_1

Type:

Family

Description:

Somatostatin (SST), also known as somatotropin release-inhibiting factor (SRIF), is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Somatostatin has a wide distribution throughout the central nervous system (CNS) as well as in peripheral tissues, for example in the pituitary, pancreas and stomach. The various actions of somatostatin are mediated by a family of rhodopsin-like G protein-coupled receptors, which comprise of five distinct subtypes: Somatostatin receptor 1 (SSTR1), Somatostatin receptor 2 (SSTR2), Somatostatin receptor 3 (SSTR3), Somatostatin receptor 4 (SSTR4) and Somatostatin receptor 5 (SSTR5) [, , ]. These subtypes are widely expressed in many tissues [, , , , , ], and frequently multiple subtypes coexist in the same cell []. The somatostatin receptor subtypes also share common signalling pathways, such as the inhibition of adenylyl cyclase [, ], activation of phosphotyrosine phosphatase (PTP), and modulation of mitogen-activated protein kinase (MAPK) through G protein-dependent mechanisms. Some of the subtypes are also coupled to inward rectifying K+ channels (SSTR2, SSTR3, SSTR4, SSTR5) [, ], to voltage-dependent Ca2+ channels (SSTR1, SSTR2) [], to an Na+/H+ exchanger (SSTR1), AMPA/kainate glutamate channels (SSTR1, SSTR2), phospholipase C (SSTR2, SSTR5), and phospholipase A2 (SSTR4) []. Amongst the wide spectrum of somatostatin effects, several biological responses have been identified that display absolute or relative subtype selectivity. These include GH secretion (SSTR2 and 5), insulin secretion (SSTR5), glucagon secretion (SSTR2), and immune responses (SSTR2) [].This entry represents SSTR1 []. In humans, it is expressed at high levels in the jejunum and stomach, with lower levels in the pancreas, colon and kidney, but it is absent in the brain. Conversely, in rodent tissue, high levels are found in the brain, but are absent in peripheral tissues []. All five human somatostatin receptors expressed in COS-7 cells are coupled to activation of phosphoinositide (PI)-specific PLC-beta; and Ca2+ mobilisation via pertussis toxin-sensitive G protein(s) with an order of potency of SSTR5 >SSTR2 >SSTR3 >SSTR4 >SSTR1 [].

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Protein Domain

IPR001184 | Somatstn_rcpt_5

Type:

Family

Description:

Somatostatin (SST), also known as somatotropin release-inhibiting factor (SRIF), is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Somatostatin has a wide distribution throughout the central nervous system (CNS) as well as in peripheral tissues, for example in the pituitary, pancreas and stomach. The various actions of somatostatin are mediated by a family of rhodopsin-like G protein-coupled receptors, which comprise of five distinct subtypes: Somatostatin receptor 1 (SSTR1), Somatostatin receptor 2 (SSTR2), Somatostatin receptor 3 (SSTR3), Somatostatin receptor 4 (SSTR4) and Somatostatin receptor 5 (SSTR5) [, , ]. These subtypes are widely expressed in many tissues [, , , , , ], and frequently multiple subtypes coexist in the same cell []. The somatostatin receptor subtypes also share common signalling pathways, such as the inhibition of adenylyl cyclase [, ], activation of phosphotyrosine phosphatase (PTP), and modulation of mitogen-activated protein kinase (MAPK) through G protein-dependent mechanisms. Some of the subtypes are also coupled to inward rectifying K+ channels (SSTR2, SSTR3, SSTR4, SSTR5) [, ], to voltage-dependent Ca2+ channels (SSTR1, SSTR2) [], to an Na+/H+ exchanger (SSTR1), AMPA/kainate glutamate channels (SSTR1, SSTR2), phospholipase C (SSTR2, SSTR5), and phospholipase A2 (SSTR4) []. Amongst the wide spectrum of somatostatin effects, several biological responses have been identified that display absolute or relative subtype selectivity. These include GH secretion (SSTR2 and 5), insulin secretion (SSTR5), glucagon secretion (SSTR2), and immune responses (SSTR2) [].This entry represents SST5R. It is expressed in range of tissues including the small intestine, heart, adrenal, cerebellum, pituitary, placenta and skeletal muscle. It is also expressed in pancreatic islets [], where somatostatin is a known regulator of insulin and glucagon secretion. All five human somatostatin receptors expressed in COS-7 cells have been shown to couple to activation of phosphoinositide (PI)-specific PLC-beta; and Ca2+ mobilisation via pertussis toxin-sensitive G protein(s) with an order of potency of SSTR5 >SSTR2 >SSTR3 >SSTR4 >SSTR1 [].

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Protein Domain

IPR001512 | Somatstn_rcpt_4

Type:

Family

Description:

Somatostatin (SST), also known as somatotropin release-inhibiting factor (SRIF), is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Somatostatin has a wide distribution throughout the central nervous system (CNS) as well as in peripheral tissues, for example in the pituitary, pancreas and stomach. The various actions of somatostatin are mediated by a family of rhodopsin-like G protein-coupled receptors, which comprise of five distinct subtypes: Somatostatin receptor 1 (SSTR1), Somatostatin receptor 2 (SSTR2), Somatostatin receptor 3 (SSTR3), Somatostatin receptor 4 (SSTR4) and Somatostatin receptor 5 (SSTR5) [, , ]. These subtypes are widely expressed in many tissues [, , , , , ], and frequently multiple subtypes coexist in the same cell []. The somatostatin receptor subtypes also share common signalling pathways, such as the inhibition of adenylyl cyclase [, ], activation of phosphotyrosine phosphatase (PTP), and modulation of mitogen-activated protein kinase (MAPK) through G protein-dependent mechanisms. Some of the subtypes are also coupled to inward rectifying K+ channels (SSTR2, SSTR3, SSTR4, SSTR5) [, ], to voltage-dependent Ca2+ channels (SSTR1, SSTR2) [], to an Na+/H+ exchanger (SSTR1), AMPA/kainate glutamate channels (SSTR1, SSTR2), phospholipase C (SSTR2, SSTR5), and phospholipase A2 (SSTR4) []. Amongst the wide spectrum of somatostatin effects, several biological responses have been identified that display absolute or relative subtype selectivity. These include GH secretion (SSTR2and 5), insulin secretion (SSTR5), glucagon secretion (SSTR2), and immune responses (SSTR2) [].This entry represents SSTR4. It is present in high levels in the pituitary, but is less abundant in the brain and peripheral tissues [, , ]. All five human somatostatin receptors expressed in COS-7 cells are coupled to activation of phosphoinositide (PI)-specific PLC-beta; and Ca2+ mobilisation via pertussis toxin-sensitive G protein(s) with an order of potency of SSTR5 >SSTR2 >SSTR3 >SSTR4 >SSTR1 [].

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Protein Domain

IPR001856 | Somatstn_rcpt_3

Type:

Family

Description:

Somatostatin (SST), also known as somatotropin release-inhibiting factor (SRIF), is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Somatostatin has a wide distribution throughout the central nervous system (CNS) as well as in peripheral tissues, for example in the pituitary, pancreas and stomach. The various actions of somatostatin are mediated by a family of rhodopsin-like G protein-coupled receptors, which comprise of five distinct subtypes: Somatostatin receptor 1 (SSTR1), Somatostatin receptor 2 (SSTR2), Somatostatin receptor 3 (SSTR3), Somatostatin receptor 4 (SSTR4) and Somatostatin receptor 5 (SSTR5) [, , ]. These subtypes are widely expressed in many tissues [, , , , , ], and frequently multiple subtypes coexist in the same cell []. The somatostatin receptor subtypes also share common signalling pathways, such as the inhibition of adenylyl cyclase [, ], activation of phosphotyrosine phosphatase (PTP), and modulation of mitogen-activated protein kinase (MAPK) through G protein-dependent mechanisms. Some of the subtypes are also coupled to inward rectifying K+ channels (SSTR2, SSTR3, SSTR4, SSTR5) [, ], to voltage-dependent Ca2+ channels (SSTR1, SSTR2) [], to an Na+/H+ exchanger (SSTR1), AMPA/kainate glutamate channels (SSTR1, SSTR2), phospholipase C (SSTR2, SSTR5), and phospholipase A2 (SSTR4) []. Amongst the wide spectrum of somatostatin effects, several biological responses have been identified that display absolute or relative subtype selectivity. These include GH secretion (SSTR2 and 5), insulin secretion (SSTR5), glucagon secretion (SSTR2), and immune responses (SSTR2) [].This entry represents SSTR3. It is widely distributed in mouse brain, with high levels in the forebrain, hippocampus and amygdala; moderate levels are also present in the substantia nigra. All five human somatostatin receptors expressed in COS-7 cells are coupled to activation of phosphoinositide (PI)-specific PLC-beta; and Ca2+ mobilisation via pertussis toxin-sensitive G protein(s) with an order of potency of SSTR5 >SSTR2 >SSTR3 >SSTR4 >SSTR1 []. Inhibition of angiogenesis has been shown to be via the SSTR3, and involves the inhibition of MAPK and endothelial nitric oxide synthase (eNOS) activity [].

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Publication

1328199 | J:2683

First Author:	Yasuda K
Year:	1992
Journal:	J Biol Chem
Title:	Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
Volume:	267
Issue:	28
Pages:	20422-8

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Publication

1346068 | J:2346

First Author:	Yamada Y
Year:	1992
Journal:	Proc Natl Acad Sci U S A
Title:	Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
Volume:	89
Issue:	1
Pages:	251-5

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Publication

10433861 | -

First Author:	Patel YC
Year:	1999
Journal:	Front Neuroendocrinol
Title:	Somatostatin and its receptor family.
Volume:	20
Issue:	3
Pages:	157-98

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Publication

8243278 | -

First Author:	Bruno JF
Year:	1993
Journal:	Endocrinology
Title:	Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat.
Volume:	133
Issue:	6
Pages:	2561-7

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Publication

8078491 | -

First Author:	O'Carroll AM
Year:	1994
Journal:	Mol Pharmacol
Title:	Characterization of cloned human somatostatin receptor SSTR5.
Volume:	46
Issue:	2
Pages:	291-8

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Publication

7907795 | -

First Author:	Buscail L
Year:	1994
Journal:	Proc Natl Acad Sci U S A
Title:	Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.
Volume:	91
Issue:	6
Pages:	2315-9

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Publication

8483934 | -

First Author:	Rohrer L
Year:	1993
Journal:	Proc Natl Acad Sci U S A
Title:	Cloning and characterization of a fourth human somatostatin receptor.
Volume:	90
Issue:	9
Pages:	4196-200

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Publication

15361490 | -

First Author:	Gugger M
Year:	2004
Journal:	Gut
Title:	Cellular detection of sst2A receptors in human gastrointestinal tissue.
Volume:	53
Issue:	10
Pages:	1431-6

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Publication

10598790 | -

First Author:	Siehler S
Year:	1999
Journal:	Naunyn Schmiedebergs Arch Pharmacol
Title:	Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity.
Volume:	360
Issue:	5
Pages:	510-21

•

Publication

7538774 | -

First Author:	Law SF
Year:	1995
Journal:	Cell Signal
Title:	Somatostatin receptor activation of cellular effector systems.
Volume:	7
Issue:	1
Pages:	1-8

•

Publication

9426226 | -

First Author:	Kreienkamp HJ
Year:	1997
Journal:	FEBS Lett
Title:	Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel (GIRK1).
Volume:	419
Issue:	1
Pages:	92-4

•

Publication

8034040 | -

First Author:	Akbar M
Year:	1994
Journal:	FEBS Lett
Title:	Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1-5, in transfected COS-7 cells.
Volume:	348
Issue:	2
Pages:	192-6

•

Publication

21469133 | J:175402

First Author:	Ripen AM
Year:	2011
Journal:	Eur J Immunol
Title:	Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t.
Volume:	41
Issue:	5
Pages:	1278-87

•

Publication

11994465 | J:127080

First Author:	Yu P
Year:	2002
Journal:	J Immunol
Title:	B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion.
Volume:	168
Issue:	10
Pages:	5117-23

•

Publication

14507421 | -

First Author:	Møller LN
Year:	2003
Journal:	Biochim Biophys Acta
Title:	Somatostatin receptors.
Volume:	1616
Issue:	1
Pages:	1-84

•

Publication

7792934 | -

First Author:	Hoyer D
Year:	1995
Journal:	Trends Pharmacol Sci
Title:	Classification and nomenclature of somatostatin receptors.
Volume:	16
Issue:	3
Pages:	86-8

•

Publication

26147686 | J:259295

First Author:	Bénézech C
Year:	2015
Journal:	Nat Immunol
Title:	Inflammation-induced formation of fat-associated lymphoid clusters.
Volume:	16
Issue:	8
Pages:	819-828

•

Publication

23188800 | J:193119

First Author:	Nakagawa Y
Year:	2012
Journal:	Proc Natl Acad Sci U S A
Title:	Thymic nurse cells provide microenvironment for secondary T cell receptor α rearrangement in cortical thymocytes.
Volume:	109
Issue:	50
Pages:	20572-7

•

Protein

O08858

Organism:	Mus musculus/domesticus
Length:	362
Fragment?:	false

•

Protein

P49660

Organism:	Mus musculus/domesticus
Length:	385
Fragment?:	false

•

Protein

P30935

Organism:	Mus musculus/domesticus
Length:	428
Fragment?:	false

•

Protein

P30875

Organism:	Mus musculus/domesticus
Length:	369
Fragment?:	false

•

Protein

P30873

Organism:	Mus musculus/domesticus
Length:	391
Fragment?:	false

•

Protein

A0A0R4J1D6

Organism:	Mus musculus/domesticus
Length:	385
Fragment?:	false

•

Protein

Q543T0

Organism:	Mus musculus/domesticus
Length:	391
Fragment?:	false

•

Protein

A0A2R8VHZ3

Organism:	Mus musculus/domesticus
Length:	121
Fragment?:	true

•

Protein

Q9JK40

Organism:	Mus musculus/domesticus
Length:	385
Fragment?:	false

•

Protein

D7NVX2

Organism:	Mus musculus/domesticus
Length:	191
Fragment?:	false

•

Protein

D7NVX3

Organism:	Mus musculus/domesticus
Length:	206
Fragment?:	false

•

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