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Search results 101 to 198 out of 198 for Sun2

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Type Details Score
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Female
Emaps: EMAPS:3278228
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468032
Specimen Label: MRC Harwell_1468032
Detected: false
Specimen Num: 10
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•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468023
Specimen Label: MRC Harwell_1468023
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468028
Specimen Label: MRC Harwell_1468028
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468035
Specimen Label: MRC Harwell_1468035
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468025
Specimen Label: MRC Harwell_1468025
Detected: true
Specimen Num: 3
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1860128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468025
Specimen Label: MRC Harwell_1468025
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3283428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468033
Specimen Label: MRC Harwell_1468033
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1842628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468036
Specimen Label: MRC Harwell_1468036
Detected: true
Specimen Num: 14
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•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7331384
Assay Type: Immunohistochemistry
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7331403
Age: postnatal day 17
Image: 2b WT
Note: Expression in inner nuclear membrane.
Specimen Label: 2b WT
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
Probe: MGI:7331384
Assay Type: Immunohistochemistry
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7331403
Age: postnatal day 17
Image: 2b KO
Note: Authors report nuclear envelope deformations charcterized by pronounced invaginations and projections protruding into sarcomeres.
Specimen Label: 2b KO
Detected: true
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1920928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468037
Specimen Label: MRC Harwell_1468037
Detected: true
Specimen Num: 15
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1685328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468030
Specimen Label: MRC Harwell_1468030
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468016
Specimen Label: MRC Harwell_1468016
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468018
Specimen Label: MRC Harwell_1468018
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468017
Specimen Label: MRC Harwell_1468017
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468019
Specimen Label: MRC Harwell_1468019
Detected: true
Specimen Num: 21
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468031
Specimen Label: MRC Harwell_1468031
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3271628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468032
Specimen Label: MRC Harwell_1468032
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3590528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468029
Specimen Label: MRC Harwell_1468029
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468034
Specimen Label: MRC Harwell_1468034
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468031
Specimen Label: MRC Harwell_1468031
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468032
Specimen Label: MRC Harwell_1468032
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468026
Specimen Label: MRC Harwell_1468026
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468021
Specimen Label: MRC Harwell_1468021
Detected: true
Specimen Num: 23
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468030
Specimen Label: MRC Harwell_1468030
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468039
Specimen Label: MRC Harwell_1468039
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468023
Specimen Label: MRC Harwell_1468023
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468028
Specimen Label: MRC Harwell_1468028
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468035
Specimen Label: MRC Harwell_1468035
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468039
Specimen Label: MRC Harwell_1468039
Detected: true
Specimen Num: 17
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Publication
21177258 | J:168852
First Author: Yu J
Year: 2011
Journal: Hum Mol Genet
Title: KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
Volume: 20
Issue: 6
Pages: 1061-73
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Publication
20724637 | J:168360
First Author: Luxton GW
Year: 2010
Journal: Science
Title: Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.
Volume: 329
Issue: 5994
Pages: 956-9
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•
Publication
37828059 | J:341625
First Author: Jiao S
Year: 2023
Journal: Nat Commun
Title: SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness.
Volume: 14
Issue: 1
Pages: 6416
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•
Publication
29878215 | J:287130
First Author: Kozono T
Year: 2018
Journal: J Biochem
Title: Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins.
Volume: 164
Issue: 4
Pages: 303-311
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•
Publication
23348741 | J:194486
First Author: Horn HF
Year: 2013
Journal: J Clin Invest
Title: The LINC complex is essential for hearing.
Volume: 123
Issue: 2
Pages: 740-50
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•
•
Publication
28966089 | J:277369
First Author: Gimpel P
Year: 2017
Journal: Curr Biol
Title: Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
Volume: 27
Issue: 19
Pages: 2999-3009.e9
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Publication
33779546 | J:304350
   
First Author: Carley E
Year: 2021
Journal: Elife
Title: The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation.
Volume: 10
•
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•
•
Publication
26975831 | J:236555
 
First Author: Thiam HR
Year: 2016
Journal: Nat Commun
Title: Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.
Volume: 7
Pages: 10997
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•
•
•
•
Publication
28533284 | J:246890
First Author: Stroud MJ
Year: 2017
Journal: J Cell Biol
Title: Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.
Volume: 216
Issue: 7
Pages: 1915-1924
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•
•
Publication
29868845 | J:263180
First Author: Dominguez Gonzalez B
Year: 2018
Journal: Hum Mol Genet
Title: Excess LINC complexes impair brain morphogenesis in a mouse model of recessive TOR1A disease.
Volume: 27
Issue: 12
Pages: 2154-2170
•
•
•
•
•
Publication
33514739 | J:302139
First Author: Ramirez-Martinez A
Year: 2021
Journal: Nat Commun
Title: The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization.
Volume: 12
Issue: 1
Pages: 690
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•
•
•
Publication
37067297 | J:339839
First Author: Ross JA
Year: 2023
Journal: Cardiovasc Res
Title: Lem2 is essential for cardiac development by maintaining nuclear integrity.
Volume: 119
Issue: 11
Pages: 2074-2088
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•
Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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•
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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•
•
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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•
•
Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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•
•
•
•
Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
•
•
•
•
•
Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
•
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
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•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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•
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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•
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
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•
•
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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•
•
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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•
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
37198162 | J:351372
First Author: Yue X
Year: 2023
Journal: Cell Death Discov
Title: Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence.
Volume: 9
Issue: 1
Pages: 167
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Allele
Tg(Sun2-EGFP)KP55Gsat | MGI:4847469
Name: transgene insertion KP55, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5004025 | STOCK Tg(Sun2-EGFP)KP55Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
22170055 | -
First Author: Zhou Z
Year: 2012
Journal: J Biol Chem
Title: Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.
Volume: 287
Issue: 8
Pages: 5317-26
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Protein Domain
IPR040994 | Sun_CC2
Type: Domain
Description: LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). The formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. SUN2 possesses two coiled-coil domains (CC1 and CC2). These coiled-coil domains are also believed to act as rigid spacers to delineate the distance between the ONM and INM of the NE. Furthermore, the two coiled-coil domains of SUN2 have been indicated to be able to directly modulate SUN domain activity and regulate the subsequent interactions between the SUN and KASH domains. CC2 forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component. Structure-based sequence analysis demonstrated that several Gly residues are located in the flexible linker regions between the three helices which would ideally provide the breaks/turns in CC2 for three-helix bundle formation. The last helix alpha3 of CC2 (that is immediately connected to the SUN domain) has been shown to be an essential segment for promoting SUN domain trimerization in the SUN-KASH complex structure [, ].
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Publication
33686165 | J:305243
First Author: Hieda M
Year: 2021
Journal: Sci Rep
Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
Volume: 11
Issue: 1
Pages: 5358
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Publication
37210724 | J:348571
First Author: Vidak S
Year: 2023
Journal: Cell Rep
Title: Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2.
Volume: 42
Issue: 5
Pages: 112534
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Publication
38821061 | J:360187
First Author: Li Y
Year: 2024
Journal: Cancer Cell
Title: Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite.
Volume: 42
Issue: 6
Pages: 985-1002.e18
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Publication
32710480 | J:294755
     
First Author: Mu X
Year: 2020
Journal: Aging Cell
Title: Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome.
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Publication
19008300 | J:144757
First Author: Puckelwartz MJ
Year: 2009
Journal: Hum Mol Genet
Title: Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice.
Volume: 18
Issue: 4
Pages: 607-20
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Publication
28625779 | J:352721
First Author: Potter C
Year: 2017
Journal: Curr Biol
Title: Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets.
Volume: 27
Issue: 13
Pages: 2014-2022.e6
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Publication
21173262 | J:169002
First Author: Folker ES
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.
Volume: 108
Issue: 1
Pages: 131-6
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Publication
28398466 | J:242915
First Author: Zhou C
Year: 2017
Journal: Hum Mol Genet
Title: Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.
Volume: 26
Issue: 12
Pages: 2258-2276
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Protein
F7AJ01
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
F6RMJ1
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein
Q9D666
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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