Type |
Details |
Score |
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3273028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691495 |
Age: |
postnatal adult |
Image: |
JAX_1801198 |
|
Specimen Label: |
JAX_1801198 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1757728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691495 |
Age: |
postnatal adult |
Image: |
JAX_1801202 |
|
Specimen Label: |
JAX_1801202 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691495 |
Age: |
postnatal adult |
Image: |
JAX_1801203 |
|
Specimen Label: |
JAX_1801203 |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691495 |
Age: |
postnatal adult |
Image: |
JAX_1801196 |
|
Specimen Label: |
JAX_1801196 |
Detected: |
true |
Specimen Num: |
42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Condon MD |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter. |
Volume: |
10 |
Issue: |
1 |
Pages: |
4263 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaltieri M |
Year: |
2015 |
Journal: |
J Cell Sci |
Title: |
α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons. |
Volume: |
128 |
Issue: |
13 |
Pages: |
2231-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Faustini G |
Year: |
2018 |
Journal: |
Acta Neuropathol |
Title: |
Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease. |
Volume: |
136 |
Issue: |
4 |
Pages: |
621-639 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kao HT |
Year: |
1999 |
Journal: |
J Exp Zool |
Title: |
Molecular evolution of the synapsin gene family. |
Volume: |
285 |
Issue: |
4 |
Pages: |
360-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kile BM |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Synapsins differentially control dopamine and serotonin release. |
Volume: |
30 |
Issue: |
29 |
Pages: |
9762-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gitler D |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Different presynaptic roles of synapsins at excitatory and inhibitory synapses. |
Volume: |
24 |
Issue: |
50 |
Pages: |
11368-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kao HT |
Year: |
2017 |
Journal: |
Eur J Neurosci |
Title: |
Synapsins regulate brain-derived neurotrophic factor-mediated synaptic potentiation and axon elongation by acting on membrane rafts. |
Volume: |
45 |
Issue: |
8 |
Pages: |
1085-1101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vasileva M |
Year: |
2012 |
Journal: |
Eur J Neurosci |
Title: |
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission. |
Volume: |
36 |
Issue: |
8 |
Pages: |
3005-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song SH |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons. |
Volume: |
36 |
Issue: |
25 |
Pages: |
6742-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bünger I |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
Maternal synapsin autoantibodies are associated with neurodevelopmental delay. |
Volume: |
14 |
|
Pages: |
1101087 |
|
•
•
•
•
•
|
Publication |
First Author: |
Venton BJ |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. |
Volume: |
26 |
Issue: |
12 |
Pages: |
3206-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Michetti C |
Year: |
2017 |
Journal: |
Cereb Cortex |
Title: |
The Knockout of Synapsin II in Mice Impairs Social Behavior and Functional Connectivity Generating an ASD-like Phenotype. |
Volume: |
27 |
Issue: |
10 |
Pages: |
5014-5023 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaffield MA |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Synaptic vesicle mobility in mouse motor nerve terminals with and without synapsin. |
Volume: |
27 |
Issue: |
50 |
Pages: |
13691-700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Longfield SF |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles. |
Volume: |
15 |
Issue: |
1 |
Pages: |
2217 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boido D |
Year: |
2010 |
Journal: |
Neuroscience |
Title: |
Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam. |
Volume: |
171 |
Issue: |
1 |
Pages: |
268-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaden JH |
Year: |
2019 |
Journal: |
Elife |
Title: |
The readily-releasable pool dynamically regulates multivesicular release. |
Volume: |
8 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gitler D |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Synapsin IIa controls the reserve pool of glutamatergic synaptic vesicles. |
Volume: |
28 |
Issue: |
43 |
Pages: |
10835-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Greco B |
Year: |
2013 |
Journal: |
Behav Brain Res |
Title: |
Autism-related behavioral abnormalities in synapsin knockout mice. |
Volume: |
251 |
|
Pages: |
65-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ketzef M |
Year: |
2011 |
Journal: |
Neuroscience |
Title: |
Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice. |
Volume: |
189 |
|
Pages: |
108-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vara H |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ERK activation in axonal varicosities modulates presynaptic plasticity in the CA3 region of the hippocampus through synapsin I. |
Volume: |
106 |
Issue: |
24 |
Pages: |
9872-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bruentgens F |
Year: |
2024 |
Journal: |
eNeuro |
Title: |
The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal Mossy Fibers in Male Mice. |
Volume: |
11 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hoffmann C |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Synapsin condensation controls synaptic vesicle sequestering and dynamics. |
Volume: |
14 |
Issue: |
1 |
Pages: |
6730 |
|
•
•
•
•
•
|
Publication |
First Author: |
Orenbuch A |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals. |
Volume: |
32 |
Issue: |
12 |
Pages: |
3969-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fornasiero EF |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner. |
Volume: |
32 |
Issue: |
35 |
Pages: |
12214-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Farisello P |
Year: |
2013 |
Journal: |
Cereb Cortex |
Title: |
Synaptic and extrasynaptic origin of the excitation/inhibition imbalance in the hippocampus of synapsin I/II/III knockout mice. |
Volume: |
23 |
Issue: |
3 |
Pages: |
581-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ketzef M |
Year: |
2014 |
Journal: |
Cereb Cortex |
Title: |
Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex. |
Volume: |
24 |
Issue: |
4 |
Pages: |
996-1008 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stavsky A |
Year: |
2024 |
Journal: |
Elife |
Title: |
Synapsin E-domain is essential for α-synuclein function. |
Volume: |
12 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HY |
Year: |
2023 |
Journal: |
Exp Mol Med |
Title: |
PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. |
Volume: |
55 |
Issue: |
11 |
Pages: |
2357-2375 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heeroma JH |
Year: |
2003 |
Journal: |
Neuroscience |
Title: |
Development of the mouse neuromuscular junction in the absence of regulated secretion. |
Volume: |
120 |
Issue: |
3 |
Pages: |
733-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gitler D |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Molecular determinants of synapsin targeting to presynaptic terminals. |
Volume: |
24 |
Issue: |
14 |
Pages: |
3711-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frederikse PH |
Year: |
2004 |
Journal: |
Mol Vis |
Title: |
Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. |
Volume: |
10 |
|
Pages: |
794-804 |
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•
•
•
•
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Publication |
First Author: |
Nishino J |
Year: |
2013 |
Journal: |
Elife |
Title: |
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. |
Volume: |
2 |
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Pages: |
e00924 |
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Publication |
First Author: |
Wang Y |
Year: |
2016 |
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Nat Commun |
Title: |
LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. |
Volume: |
7 |
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10481 |
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•
•
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Publication |
First Author: |
Munton RP |
Year: |
2007 |
Journal: |
Mol Cell Proteomics |
Title: |
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. |
Volume: |
6 |
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2 |
Pages: |
283-93 |
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•
•
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Publication |
First Author: |
Ehringer MA |
Year: |
2001 |
Journal: |
Mamm Genome |
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High-throughput sequence identification of gene coding variants within alcohol-related QTLs. |
Volume: |
12 |
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8 |
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657-63 |
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Publication |
First Author: |
Sundberg JP |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. |
Volume: |
12 |
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e0180682 |
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Nature |
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High-throughput discovery of novel developmental phenotypes. |
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7621 |
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First Author: |
The Jackson Laboratory |
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Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
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Koscielny G |
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Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
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Database issue |
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Publication |
First Author: |
Velocigene |
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MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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Publication |
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Wellcome Trust Sanger Institute |
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MGI Direct Data Submission |
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Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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The Gene Ontology Consortium |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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Gene Ontology annotation through association of InterPro records with GO terms |
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MGI Sequence Curation Reference |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Protein Domain |
Type: |
Family |
Description: |
The synapsins are a family of neuron-specific phosphoproteins that coatsynaptic vesicles and are involved in the binding between these vesiclesand the cytoskeleton (including actin filaments). The family comprises 5homologous proteins 1a, 1b, 2a, 2b and 3. Synapsins 1, 2, and 3 areencoded by 3 different genes. The a and b isoforms of synapsin 1 and 2 aresplice variants of the primary transcripts [].This entry represents synapsin-2 (SYN2) and synapsin-3 (SYN3). SYN2 is thought to be involved in noradrenaline secretion by sympathetic neurons []. SYN3 is expressed in cells of the subgranular layer of the hippocampal dentate gyrus []. It may function in neurogenesis and synaptic plasticity []. Unlike SYN1 and SYN2, deletion of SYN3 does not cause seizures or an apparent neurological phenotype and has relatively subtle effects on neurotransmission []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
48
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
82
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
586
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
579
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
579
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
579
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
313
 |
Fragment?: |
false |
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Publication |
First Author: |
Nomura M |
Year: |
2000 |
Journal: |
Neurosci Res |
Title: |
Upregulation of synapsin IIa and IIb mRNAs in the paraventricular and supraoptic nuclei in chronic salt loaded and lactating rats. |
Volume: |
37 |
Issue: |
3 |
Pages: |
201-10 |
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