Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1620421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 13.0 |
Image: |
3C |
|
Specimen Label: |
3C |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1620421 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 13.0 |
Image: |
3D |
Note: |
Expression is particularly strong in the adventitia and endothelium. |
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634616 |
Pattern: |
Regionally restricted |
Stage: |
TS16 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 10.0 |
Image: |
3B |
Note: |
Expression is in the epithelial layers. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634621 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 13.0 |
Image: |
3C |
|
Specimen Label: |
3C |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1683424 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 16.0 |
Image: |
4H |
Note: |
Staining is nuclear in the muscle cells of the muscularis propria. |
Specimen Label: |
4H |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611716 |
Pattern: |
Not Specified |
Stage: |
TS16 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 10.0 |
Image: |
1A |
|
Specimen Label: |
1A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611718 |
Pattern: |
Not Specified |
Stage: |
TS18 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 11.0 |
Image: |
1B |
|
Specimen Label: |
1B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611718 |
Pattern: |
Not Specified |
Stage: |
TS18 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 11.0 |
Image: |
4A |
|
Specimen Label: |
4A |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1715218 |
Pattern: |
Not Specified |
Stage: |
TS18 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 11.0 |
Image: |
1B |
|
Specimen Label: |
1B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267918 |
Pattern: |
Not Specified |
Stage: |
TS18 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 11.0 |
Image: |
1B |
|
Specimen Label: |
1B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619114 |
Pattern: |
Not Specified |
Stage: |
TS14 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 9.0 |
Image: |
2A,B |
|
Specimen Label: |
2A,B |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1608914 |
Pattern: |
Graded |
Stage: |
TS14 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 9.0 |
Image: |
2A,B |
Note: |
The ependymal layer and alar plate exhibit the highest staining with decreasing expression toward the mantle layer. |
Specimen Label: |
2A,B |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 12.0 |
Image: |
1C |
|
Specimen Label: |
1C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 13.0 |
Image: |
1D |
Note: |
The highest expression is maintained in actively dividing tissues and neuronal progenitors prior to terminal differentiation. |
Specimen Label: |
1D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 14.0 |
Image: |
1E |
Note: |
The highest expression is maintained in actively dividing tissues and neuronal progenitors prior to terminal differentiation. |
Specimen Label: |
1E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287324 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 16.0 |
Image: |
4I |
Note: |
Staining is cytoplasmic. |
Specimen Label: |
4I |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1701524 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 16.0 |
Image: |
3E,F,G |
Note: |
Expression is particularly strong in the adventitia and endothelium. |
Specimen Label: |
3E,F,G |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689420 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 12.0 |
Image: |
1C |
|
Specimen Label: |
1C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 13.0 |
Image: |
1D |
Note: |
The highest expression is maintained in actively dividing tissues and neuronal progenitors prior to terminal differentiation. |
Specimen Label: |
1D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689422 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 14.0 |
Image: |
1E |
Note: |
The highest expression is maintained in actively dividing tissues and neuronal progenitors prior to terminal differentiation. |
Specimen Label: |
1E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689420 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 12.0 |
Image: |
2E |
|
Specimen Label: |
2E |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274821 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 13.0 |
Image: |
3C |
|
Specimen Label: |
3C |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3629195 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-07-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1717122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3629200 |
Age: |
embryonic day 14.0 |
Image: |
1E |
|
Specimen Label: |
1E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
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Wilde JJ |
Year: |
2017 |
Journal: |
J Neurosci |
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2565-2579 |
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•
•
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Publication |
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Mol Cell Biol |
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The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. |
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•
•
•
•
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Publication |
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Still IH |
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2004 |
Journal: |
BMC Evol Biol |
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Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. |
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4 |
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16 |
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•
•
•
•
•
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Publication |
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Xie Z |
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Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. |
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79-93 |
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•
•
•
•
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Publication |
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Hemberger M |
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2000 |
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Dev Biol |
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cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion. |
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222 |
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1 |
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•
•
•
•
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Publication |
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Cell Mol Biol (Noisy-le-grand) |
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Exchangeable gene trap using the Cre/mutated lox system. |
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•
•
•
•
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Publication |
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2005 |
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Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. |
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•
•
•
•
•
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Publication |
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The Jackson Laboratory |
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2012 |
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MGI Direct Data Submission |
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Alleles produced for the KOMP project by The Jackson Laboratory |
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•
•
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•
•
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Publication |
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The Gene Ontology Consortium |
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Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
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Database Download |
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WashU-HHMI Mouse EST Project |
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UniProt-GOA |
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2012 |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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Mouse Genome Informatics Scientific Curators |
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MGI Sequence Curation Reference |
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The transcriptional landscape of the mammalian genome. |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Database Download |
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Mouse Gene Trap Data Load from dbGSS |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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UniProt-GOA |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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The Jackson Laboratory Mouse Radiation Hybrid Database |
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Mouse T31 Radiation Hybrid Data Load |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Scientific Curators |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Database Download |
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MGI-UniGene Interconnection Effort |
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Annotation inferences using phylogenetic trees |
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Entrez Gene Load |
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Allen Institute for Brain Science |
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Allen Institute |
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Mouse Genome Informatics Scientific Curators |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Database Download |
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Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Gergely F |
Year: |
2000 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. |
Volume: |
97 |
Issue: |
26 |
Pages: |
14352-7 |
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Publication |
First Author: |
Mortuza GB |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation. |
Volume: |
5 |
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Pages: |
5072 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1) []. TACC 3 from Xenopus laevis, also known as maskin, associates XMAP215 and promotes efficient microtubule elongation during mitosis []. Maskin is also found to bind CPEB and elF-4E []. Interestingly, the functional homologue (Alp7) in Schizosaccharomyces pombe (not included in this entry) has been shown to be required for organisation of bipolar spindles []. |
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Publication |
First Author: |
Still IH |
Year: |
1999 |
Journal: |
Genomics |
Title: |
The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. |
Volume: |
58 |
Issue: |
2 |
Pages: |
165-70 |
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Publication |
First Author: |
Cully M |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis. |
Volume: |
65 |
Issue: |
22 |
Pages: |
10363-70 |
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Publication |
First Author: |
Long MD |
Year: |
2019 |
Journal: |
Oncogene |
Title: |
The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression. |
Volume: |
38 |
Issue: |
3 |
Pages: |
421-444 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1149
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
631
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
774
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
630
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2879
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
555
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
558
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
829
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1020
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
910
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1146
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
696
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1033
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
136
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
426
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
776
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1036
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
568
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
157
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
630
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
637
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Fragment?: |
false |
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Publication |
First Author: |
Sato M |
Year: |
2004 |
Journal: |
Mol Biol Cell |
Title: |
Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation. |
Volume: |
15 |
Issue: |
4 |
Pages: |
1609-22 |
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Publication |
First Author: |
Stebbins-Boaz B |
Year: |
1999 |
Journal: |
Mol Cell |
Title: |
Maskin is a CPEB-associated factor that transiently interacts with elF-4E. |
Volume: |
4 |
Issue: |
6 |
Pages: |
1017-27 |
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